JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2014, Vol. 28 ›› Issue (5): 45-48.doi: 10.6040/j.issn.1673-3770.0.2014.042
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ZHENG Jiong, LI Jing
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| [1] | ZHANG Yongcai, ZHANG Jiang, LU Hui, XING Kexin, WU Jingfang, XUE Gang, LI Yanping, LIU Yanbin. Expression and significance of CXCL10 and IFN-γ in antrochoanal polyp [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(2): 7-12. |
| [2] | Nasal polyps(NP)are frequently divided into subtypes, including eosinophilic and neutrophilic, among others, according to their endotypes. However, the mechanisms of neutrophilic NP need to be further elucidated. This study explores the influence of 2-aminoethoxydiphenyl borate(2-APB)on inflammatory reactions of neutrophilic NP in vitro. MethodsWe used immunofluorescence and immunohistochemical staining to detect the infiltration of neutrophils(NEU)in normal nasal mucosa and NP tissues. These tissues were subsequently cultured in vitro using an organ culture technique, and concentrations of Orai1 and myeloperoxidase(MPO)were determined using enzyme-linked immunosorbent assay(ELISA). 2-APB was administered to both cultures, and the measurement of Orai1 and MPO concentrations using ELISA was repeated. ResultsAll samples were identified as neutrophilic NP. The number of NEU was higher in NP than in normal nasal mucosa. Concentrations of Orai1 and MPO were also higher in NP cultured in vitro than in normal tissue. After the administration of 2-APB, Orai1 protein and the mediator MPO were reduced significantly in the cultures. Conclusion2-APB may inhibit inflammatory reactions of neutrophilic NP in vitro.. 2- aminoethoxydiphenyl borate inhibits inflammatory reactions of neutrophilic nasal polyps in vitroDAI Fei, WEI Jinjin, TANG Xinyue, CHEN Zheng, LIN Lin Department of Otorhinolaryngology-Head and Neck Surgery, Huashan Hospital North of Fudan University, Shanghai 201907, ChinaAbstract:Objective〓 [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 97-100. |
| [3] | LI Yong. The difficulties, challenges, and strategy for diagnosing and treating pediatric sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(6): 1-7. |
| [4] | XU Geng. CT scans should not be routinely used for diagnosing chronic sinusitis in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(6): 8-9. |
| [5] | ZHU Luping, CHEN Juan, ZHU Lei, CHEN Renjie. A child with acute rhinosinusitis, acute glomerulonephritis and an orbital abscess: case report [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(6): 41-44. |
| [6] | Guohui CHEN,Shouhuan HE,Qing SUN,Tianle GAO,Guangping BAI. Clinical effects of different middle turbinate treatments on chronic rhinosinusitis with nasal polyps during endoscopic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 82-86. |
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| [8] | Huabin LI,Yuting LAI,Wenxiu JIANG. Endotypes and precision medicine in chronic sinusitis treatment [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(3): 9-13. |
| [9] | Changyu QIU,Jun ZHOU,De′en ZHUANG,Qing YANG,Meiping LU,Lei CHENG. Artificial intelligence technology application in disclosing allergic rhinitis patients′ needs to otolaryngologists [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(3): 88-94. |
| [10] | Meiping LU,Lei CHENG. Current status of genetic research on allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(3): 36-41. |
| [11] | Yu ZHANG,Xicheng SONG. Advances in interaction mechanisms and treatment strategy between chronic rhinosinusitis with nasal polyp and asthma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 49-52. |
| [12] | Hongmeng YU,Zhuofu LIU,Qi DAI. Endoscopic sinus surgery for chronic sinusitis with asthma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 38-41. |
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| [14] | WANG Jianwei, ZHANG Yu, SONG Xicheng. Analysis of pulmonary function of patients who developed chronic rhinosinusitis with nasal polyps and asthma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 103-108. |
| [15] | ZHANG Wei, LIU Yonggang, JIANG Lingyan. Clinical effect of budesonide nasal irrigation shortly after functional endoscopic endonasal surgery of chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 128-130. |
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