JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2015, Vol. 29 ›› Issue (2): 9-11.doi: 10.6040/j.issn.1673-3770.0.2014.347

Previous Articles     Next Articles

Meta analysis of nasal corticosteroid treatment in the children with obstructive sleep apnea hypopnea syndrome

CHEN Xi, LI Jin-rang   

  1. Department of Otolaryngology & Head and Neck Surgery, Navy General Hospital, Beijing 100048, China
  • Received:2014-11-02 Online:2015-04-16 Published:2015-04-16

PDF (PC)

528

Abstract: Objective To investigate the effectiveness of nasal corticosteroids to treat the children with obstructive sleep apnea hypopnea syndrome (OSAHS) using meta-analysis. Methods The published articles were searched from PubMed, Chinese Biomedical Literature CD-ROM databases, and China Academic Journals Full-text database bases on the inclusion and exclusion criteria. The results of the found studies were analyzed. Results 3 English articles and 88 cases were finally included. The results of Meta analysis showed that application of nasal corticosteroids significantly reduced the weighted mean AHI[weighted mean difference (WMD)=4.07, 95% CI(0.00, 8.14), P<0.000 01]. Conclusion Nasal corticosteroids may be helpful in ameliorating children with OSAHS.

Key words: Sleep apnea hypopnea syndrome, obstructive, Meta analysis, Nasal corticosteroids, Child

CLC Number: 

  • R766.7
[1] 中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉科学分会.儿童阻塞性睡眠呼吸暂停低通气综合征诊疗指南草案(乌鲁木齐)[J].中华耳鼻咽喉头颈外科杂志,2007,42(2):83-84.Editorial Committee of Chinese Journal of Otorhinolaryngology Head and neck surgery, The Chinese Medical Association otolaryngology branch. Clinicl practice guideline draft (Urumqi): diagnosis and management of childhood obstructive sleep apnea syndrome[J]. Chin J Otorhinolaryngol Head Neck Surg, 2007, 42(2):83-84. Editorial Committee of Chinese Journal of Otorhinolaryngology Head and neck surgery, The Chinese Medical Association otolaryngology branch. Clinicl practice guideline draft (Urumqi): diagnosis and management of childhood obstructive sleep apnea syndrome[J]. Chin J Otorhinolaryngol Head Neck Surg, 2007, 42(2):83-84.
[2] Brietzke S E, Gallagher D. The effectiveness of tonsillectomy and adenoidectomy in the treatment of pediatric obstructive sleep apnea/hypopnea syndrome: a meta-analysis[J]. Otolaryngol Head Neck Surg, 2006, 134(6):979-984.
[3] 庞宇峰, 龚静蓉.鼻用皮质类固醇激素治疗腺样体肥大文献的Meta分析[J].中华临床医师杂志:电子版,2012, 6(20):6388-6391. PANG Yufeng, GONG Jingrong. Efficacy of intranasal corticosteroids in the treatment of adenoidal hypertrophy: a Meta-analysis[J]. Chin J Clinic: Electr Edit, 2012, 6(20):6388-6391.
[4] Certal V, Catumbela E, Winck J C, et al. Clinical assessment of pediatric obstructive sleep apnea: a systematic review and meta-analysis[J]. Laryngoscope, 2012, 122(9):2105-2114.
[5] De Luca Canto G, Singh V, Major M P, et al. Diagnostic capability of questionnaires and clinical examinations to assess sleep-disordered breathing in children: a systematic review and meta-analysis[J]. J Am Dent Assoc, 2014, 145(2):165-178.
[6] Brouillette R T, Manoukian J J, Ducharme F M, et al. Efficacy of fluticasone nasal spray for pediatric obstructive sleep apnea[J]. J Pediatr, 2001, 138(6):838-844.
[7] Kheirandish-Gozal L, Gozal D. Intranasal budesonide treatment for children with mild obstructive sleep apnea syndrome[J]. Pediatrics, 2008, 122(1):e149-155.
[8] Alexopoulos E I, Kaditis A G, Kalampouka E, et al. Nasal corticosteroids for children with snoring[J]. Pediatric Pulmonology, 2004, 38(2):161-167.
[9] Modrzynski M, Zawisza E. An analysis of the incidence of adenoid hypertrophy in allergic children[J]. Int J Pediatr Otorhinolaryngol, 2007, 71(5):713-719.
[10] Demain J G, Goetz D W. Pediatric adenoidal hypertrophy and nasal airway obstruction: reduction with aqueous nasal beclomethason[J]. Pediatrics, 1995, 95(3):355-364.
[11] Goldbart A D, Veling M C, Goldman J L, et al. Glucocorticoid receptor subunit expression in adenotonsillar tissue of children with obstructive sleep apnea[J]. Pediatr Res, 2005, 57(2):232-236.
[12] Kheirandish-Gozal L, Serpero L D, Dayyat E, et al. Corticosteroids suppress in vitro tonsillar proliferation in children with obstructive sleep apnea[J]. Eur Respir J, 2009, 33(5):1077-1084.
[13] Esteitie R, Emani J, Sharma S, et al. Effect of fluticasone furoate on interleukin 6 secretion from adenoid tissues in children with obstructive sleep apnea[J]. Arch Otolaryngol Head Neck Surg, 2011, 137(6):576-582.
[14] Costa D J, Mitchell R. Adenotonsillectomy for obstructive sleep apnea in obese children: a meta-analysis[J]. Otolaryngol Head Neck Surg, 2009, 140(4):455-460. [2] Brietzke S E, Gallagher D. The effectiveness of tonsillectomy and adenoidectomy in the treatment of pediatric obstructive sleep apnea/hypopnea syndrome: a meta-analysis[J]. Otolaryngol Head Neck Surg, 2006, 134(6):979-984.
[1] LI Shiyun, XIE Yan, PAN Jiayu, CHEN Meixin, LONG Dan, ZHANG Chunlin. Meta analysis of clinical efficacy of cochlear implant in elderly patients with postlingual deafness [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(3): 20-30.
[2] ZHU Xiqian, WANG Jia, SUN Zuxian, FENG Jianxiu, ZHANG Mengjia, ZHAO Ying, WANG Hong, JIANG Minmin. Refractive status of school-aged children aged 6-9 years in Yangpu District, Shanghai, 2022-2024: a cohort study [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(3): 102-109.
[3] SONG Yanling, SI Yuanyuan, CUI Yan. Minimal quantity vitrectomy for laser-pointer induced full-thickness macular hole in a child: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 144-147.
[4] XIONG Qin, ZHANG Yan, WU Rina, LI Feng, TANG Lixing. Application of intranasal corticosteroids in pediatrics [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 160-167.
[5] LIU Nanxian, YANG Zeyin, HAN Lin, ZHANG Aiying, ZHAO Yuliang, XUE Jing, SUN Yijun, SHAO Yongliang. Significance of video-EEG in the diagnosis of recurrent vertigo in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 20-25.
[6] HUANG Huan, HUA Hongli, DENG Yuqin, JIANG Chengyang, WANG Yuwei, YANG Xinghai. Correlation of allergic rhinitis, tonsil adenoid hypertrophy, and sinusitis in children and analysis of its clinical guiding value [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 34-41.
[7] WANG Hua, ZHANG Fengzhen, LONG Ting, ZHAO Jing, LI Hongbin, WANG Shengcai, WANG Guixiang. Analysis of the reasons and prognostic outcomes for tracheostomy in pediatric patients following posterior fossa tumor resection [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 168-173.
[8] HUANG Aiping, WANG Juan, WANG Li, GENG Jiangqiao, WANG Yafang, WEN Xin. Tonsil Burkitt lymphoma involving pulmonary and maxilla in children: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 148-152.
[9] LIU Chang, YANG Jingpu, GAO Yu, WANG Wenjia. Analysis of allergen detection results in children with allergic rhinitis in the Changchun area [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 51-58.
[10] FU Shengyao, CHEN Min, PANG Wenhui, LI Na. Endoscopic-assisted individualized surgical approach for the treatment of nasal dermoid and sinus cysts in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 65-71.
[11] CHEN Danping, HE Zijian, YU Youjun, ZHOU Xiaowei. Analysis of the efficacy and prognostic factors of hospitalized cases of children with sudden sensorineural hearing loss for ten years [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 16-22.
[12] YANG Na, LIU Yin, GUO Bao, JI Yaofeng, CHENG Chen, ZHANG Chen, DONG Lina. High frequency ultrasound in closed reduction of nasal fracture in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 41-45.
[13] WANG Dengmao, WEN Xin, GENG Jiangqiao, ZHANG Guangyuan, LIU Xiaofeng. Tubal hair polyp complicated with nasopharyngeal hamartoma in children: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 105-109.
[14] YAO Tingting, ZHANG Delun, LI Lan. A case of infantile hypopharyngeal gastric mucosal ectasia causing pharyngeal reflux symptoms and review of the literature [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(6): 126-130.
[15] ZHANG Xiao, LIU Haihong, LIU Wei, LI Ying, CHEN Min, LIU Bing, BAI Jie, ZHANG Jie, ZHENG Jun, YANG Yang. Analysis of clinical data form 112 cases of children with congenital single-sided deafness [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(4): 96-196.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd