JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2017, Vol. 31 ›› Issue (1): 110-113.doi: 10.6040/j.issn.1673-3770.0.2016.328

Previous Articles     Next Articles

Clinical observation on the treatment of BRVO-ME by the combination of laser therapy with Ranibizumab intravitreal injection.

  

  1. Department of Ophthalmology, Second Peoples Hospital of Foshan, Foshan 528000, Guangdong, China
  • Received:2016-07-27 Online:2017-02-16 Published:2017-02-16

PDF (PC)

584

Abstract: Objective To explore the clinical efficacy of branch retinal vein occlusion secondary macular edema(BRVO-ME)treated with Ranibizumab intravitreal injection combined with grille laser photocoagulation(GLP). Methods A total of 135(135 eyes)BRVO-ME cases were divided into 3 groups: simple drug group(n=45), simple laser group(n=45), and combined treatment group(n=45). The simple drug group received Ranibizumab intravitreal injection only. The simple laser group received GLP only. The combined treatment group received Ranibizumab intravitreal injection first, and then GLP 1 week after. The best corrected visual acuity(BCVA), central macular thickness(CMT), and intraocular pressure(IOP)of the 3 groups were observed. Results Three months after treatment, BCVA and CMT of all groups were significantly different(P<0.05). The combined treatment group had significantly lower BCVA and CMT than the other 2 groups in postoperative month 1, 2 and 3(P<0.05). During the treatment, no increased IOP was observed(P>0.05). No postoperative infection, vitreous hemorrhage, bacterial endophthalmitis or other adverse reactions occurred. Conclusion Ranibizumab intravitreal injection combined with GLP is safe and effective in the treatment of BRVO-ME, which can reduce the CMT, relieve macular edema, and improve visual acuity.

Key words: Ranibizumab, Grille laser photocoagulation, Branch retinal vein occlusion, Macular edema

CLC Number: 

  • R774.5
[1] 王晓波,吴国基,张雪岩,等. 玻璃体腔注射雷珠单抗联合激光治疗视网膜分支静脉阻塞[J]. 国际眼科杂志,2013,25(12):2452-2455. WANG Xiaobo, WU Guoji, ZHANG Xueyan, et al. Intravitreous injection with ranibizumab combined laser photocoagulation for the treatment of branch retinal vein occlusion[J]. Int Eye Sci, 2013, 25(12):2452-2455.
[2] 吴李鑫,张悦,刘海芸,等. 玻璃体腔注射雷珠单抗联合激光治疗视网膜中央静脉阻塞继发黄斑水肿[J].中国实用眼科杂志,2015,33(9):1004-1007. WU Lixin, ZHANG Yue, LIU Haiyun, et al. Intravitreal ranibizumab combined with grid photocoagulation for macular edema of central retinal vein occlusion[J]. Chin J Pract Ophthalmol, 2015, 33(9):1004-1007.
[3] 叶湘湘,陈中山,丁琴,等. 玻璃体腔注射雷珠单抗与光动力疗法联合玻璃体腔注射雷珠单抗治疗特发性脉络膜新生血管的疗效比较[J]. 中华眼底病杂志,2013,29(4):362-366. YE Xiangxiang, CHEN Zhongshan, DING Qin, et al. Intravitreal ranibizumab injection combined with or without photodynamic therapy for idiopathic choroidal neovascularization: a comparative efficacy study[J]. Chi J Ocul Fund Dis, 2013, 29(4):362-366.
[4] 傅维娜,陈梅珠,王云鹏. 手术前玻璃体腔注射雷珠单抗对增生型糖尿病视网膜病变患眼玻璃体切割手术操作时间及手术后视力的影响[J]. 中华眼底病杂志,2016,32(1):26-30. FU Weina, CHEN Meizhu, WANG Yunpeng. The effect of preoperative intravitreal ranibizumab injection on the operation duration of vitrectomy and postoperative vision for the treatment of proliferative diabetic retinopathy[J]. Chi J Ocul Fund Dis, 2016, 32(1):26-30.
[5] Battaglia Parodi M, Saviano S, Bergamini L, et al. Grid laser treatment of macular edema in macular branch retinal vein occlusion[J]. Doc Ophthalmol, 1999, 97(3-4):427-431.
[6] 吕勇,范琼艳,杨琳,等. 老年白内障手术联合玻璃体腔注射雷珠单抗对糖尿病性黄斑水肿影响[J]. 中国实用眼科杂志,2014,32(5):560-563. LÜ Yong, FAN Qiongyan, YANG Lin, et al. Effect of combined senile diabetic cataract surgery and intravitreal lucentis injection on diabetic macular edema[J]. Chin J Pract Ophthalmol, 2014, 32(5):560-563.
[7] 刘会娟,宋艳萍,陈中山,等. 玻璃体腔注射雷珠单抗与玻璃体腔注射雷珠单抗联合光动力疗法治疗息肉样脉络膜血管病变的视力预后比较[J]. 中华眼底病杂志,2014, 30(3):249-252. LIU Huijuan, SONG Yanping, CHEN Zhongshan, et al. Comparison of visual outcomes between intravitreal ranibizumab injection combined with or without photodynamic therapy for polypoidal choroidal vasculopathy[J]. Chi J Ocul Fund Dis, 2014, 30(3):249-252.
[8] Cakir M, Dogan M, Bayraktar Z, et al. Efficacy of intravitreal triamcinolone for the treatment of macular edema secondary to branch retinal vein occlusion in eyes with or without grid laser photocoagulation[J]. Retina, 2008, 28(3):465-472.
[9] Kocabora MS, Yilmazli C, Taskapili M, et al. Development of ocular hypertension and persistent glaucoma after intravitreal injection of triamcinolone[J]. Clin Ophthalmol, 2008, 2(1):167-171.
[10] Evoy KE, Abel SR. Ranibizumab: the first vascular endothelial growthfactor inhibitor approved for the treatment of diabetic macular edema[J]. Ann Pharmacother, 2013, 47(6):811-818.
[1] ZHU Mingqiong, LI Zheng, LIU Ru, TIAN Tao, PENG Jingli, LYU Qianyi, TAN Huaxia. The application of AI screening system based on OCT/OCTA in the evaluation of the effect of anti VEGF treatment in patients with diabetes macular edema [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 68-73.
[2] SUN Qingzhu, SHEN Jian, CHEN Xing, WU Yanbing, ZENG Lun. The role of metabolic indicators in predicting ranibizumab efficacy in diabetic macular edema [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 74-81.
[3] ZHU Yunlong, WANG Ping, GAO Meng. A case of posterior scleritis initially misdiagnosed as central serous chorioretinopathy and retinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 99-105.
[4] DING Shuliang, WANG Chaofan, LIU Jianliang. A case of intraocular fluid detection to guide precise treatment of acute retinal necrosis and review of the literature [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 114-117.
[5] SHEN Jiaqi, LI Xiaosa, BI Yanlong, ZHANG Jingfa. The application of artificial intelligence in screening, diagnosis and prognosis of diabetic macular edema [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 153-159.
[6] BAO Ying, LIU Zhigao, JANG Pengfei, CUI Wenxuan, ZHENG Xiaoxia, YANG Mengyao, SI Mingwei, WANG Yu, WANG Hong. Clinical observation of compacept in the treatment of diabetes mellitus with CRVO-ME high reflex point [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 55-60.
[7] CHANG Weiwei, JIAO Wanzhen, CUI Yanyan, ZHAO Jie, LIU Zhaoqiang, ZHAO Bojun. Research progress of diabetic macular ischaemia [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 130-136.
[8] ZHOU Jinglin, LI Jinxiang, ZENG Qi. Effect of 577 nm subthreshold micropulse laser photocoagulation combined with anti-VEGF on the treatment of refractory diabetic macular edema [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(2): 18-25.
[9] HE Jing, LEI Chunyan, ZHANG Meixia. Association of glycosylated hemoglobin variation index with diabetic retinopathy severity [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(2): 34-40.
[10] GU Ranran, LI Fengjiao, JIAO Wanzhen, CUI Yanyan, ZHAO Bojun. Clinical efficacy of lecithin complex iodine capsule in the adjuvant treatment of retinal vein occlusion [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(5): 46-50.
[11] ZHANG Taoran, WANG Wei, LI Mingming, HUANG Yingxiang. Subfoveal choroidal thickness changes following intravitreal ranibizumab treatment in choroidal neovascularization due to pathological myopia [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(2): 68-71.
[12] Keyang HAN,Beibei YU,Bojun ZHAO. Morphological structure analysis of the macular area after anti-VEGF treatment for short-term retinal vein occlusion [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 129-131.
[13] LIU Jianbo, ZHANG Huan. Phacoemulsification combined with intravitreal ranibizumab or triamcinolone acetonide injection for the treatment of cataract accompanied by diabetic macular edema [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(2): 99-104.
[14] ZHOU Xueyi, LI Yiming, WANG Meiju, ZHANG Yuanyuan, ZHANG Lizhuo. The application of 25-gauge minimally invasive vitreoretinal surgery combined with intravitreal ranibizumab injections in the treatment of proliferative diabetic retinopathy. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 87-89.
[15] . Clinical observation on the treatment of CSME and NCSME by intravitreal injection of ranibizumab. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(2): 96-98.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd