山东大学耳鼻喉眼学报 ›› 2017, Vol. 31 ›› Issue (1): 70-74.doi: 10.6040/j.issn.1673-3770.0.2016.533

• 综述 • 上一篇    下一篇


梁小红,李艳,彭万达,宗赟综述, 李翀审校   

  1. 苏州大学第三附属医院 呼吸科, 江苏 常州 213000
  • 收稿日期:2016-12-28 出版日期:2017-02-16 发布日期:2017-02-16
  • 通讯作者: 李翀. E-mail:zeyou06@163.com

Obstructive sleep apnea and cancer: a review.

  1. Department of Respiratory, the Third Affiliated Hospital of Soochow University, Changzhou 213000, Jiangsu, China
  • Received:2016-12-28 Online:2017-02-16 Published:2017-02-16

摘要: 近年来,许多流行病学研究发现阻塞性睡眠呼吸暂停(OSA)和肿瘤患病率存在相关性。大量动物实验和临床研究进一步证实OSA与肿瘤发生和进展相关,目前研究表明其机制主要涉及以下方面:氧化应激、炎症反应、交感神经兴奋性增高、免疫功能异常、外泌体、低氧诱导因子(HIF)等。

关键词: 睡眠呼吸暂停,阻塞性, 流行病学研究, 肿瘤, 机制

Abstract: Several studies have recently demonstrated that patients with obstructive sleep apnea(OSA)have a high prevalence of cancer and cancer-related mortality. A large number of animal experiments and clinical studies have further confirmed that OSA can be involved in tumorigenesis and progression. The mechanism may involve oxidative stress, systemic inflammation, sympathetic outflow, immune dysfunction, exosomes, hypoxia-inducible factor(HIF), and so on.

Key words: Neoplasms, Epidemiology, Mechanism, Sleep apnea, obstructive


  • R766.7
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