山东大学耳鼻喉眼学报 ›› 2023, Vol. 37 ›› Issue (3): 11-20.doi: 10.6040/j.issn.1673-3770.0.2022.262

• 论著 • 上一篇    

近现代名老中医治疗眩晕用药规律的数据挖掘探析

周熠星1,李丹1,陈腾宇2,周敏3,黄家钱1,王森1,罗诗威1,何伟平4   

  1. 1.广州中医药大学 第一临床医学院, 广东 广州 510405;
    2. 中山大学附属第五医院 耳鼻喉科, 广东 珠海 519000;
    3. 中山大学附属第三医院 过敏科, 广东 广州 510630;
    4. 广州中医药大学第一附属医院 耳鼻喉科, 广东 广州 510405
  • 发布日期:2023-05-24
  • 通讯作者: 何伟平. E-mail: drhwp@163.com
  • 基金资助:
    国家自然科学基金面上项目(81974581);2020年阮岩省名中医传承工作室项目(2100600145)

Data mining on the pattern of medication in the management of vertigo by famous veteran Chinese medicine practitioners in modern times

ZHOU Yixing1, LI Dan1, CHEN Tengyu2, ZHOU Min3, HUANG Jiaqian1, WANG Sen1, LUO Shiwei1, HE Weiping4   

  1. 1. The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China;
    2. Department of Otolaryngology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, Guangdong, China;
    3. Department of Allergy, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong, China;
    4. Department of Otolaryngology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China
  • Published:2023-05-24

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摘要： 目的 通过分析近现代名老中医治疗眩晕处方用药及其配伍规律,为中医临床治疗眩晕提供参考。 方法 通过比对纳入与排除标准,收集整理7部书籍中治疗眩晕的医案,进行频数、四气五味、归经及功效分类统计后,使用Origin 2022软件绘制中药功效及药性雷达图,采用IBM SPSS Modeler 18.0及Cytoscape 3.9.1软件进行核心中药网络展示,并通过R 4.2.0软件进行相关性、关联规则分析及可视化,应用 SPSS Statistics 26.0软件对高频药物进行聚类分析。 结果 共收集到近现代名老中医治疗眩晕的178个医案、297个处方以及289味中药。总用药频次为3 684次,其中,药物功效以补虚药、平肝息风药、清热药、解表药及活血化瘀药为主;四气以寒、温为主,五味以甘、苦、辛居多,归经以肝、脾、肺三经为主;使用频数≥30次的中药有37味;相关系数较高的前40个药对多为补虚药、活血化瘀药及平肝息风药,常用药对为龙骨-牡蛎,常使用的角药组合共6个,治疗眩晕的新处方有4个。 结论 名老中医治疗眩晕以平肝息风、补益气血、化痰祛湿、活血通窍等为主,体现了临床治疗眩晕基本原则。研究通过探析名老中医治疗眩晕的用药规律,为临床中成药及新药研发提供理论基础,有助于更深入全面的继承与发扬名老中医治疗眩晕的宝贵经验。

关键词: 眩晕, 名老中医, 组方规律, 核心药物, 数据挖掘

Abstract: Objective To provide a reference for the clinical treatment of dizziness in Chinese herbal medicine by analyzing the prescriptions of modern famous veteran Chinese medicine practitioners for vertigo and compatibility rules. Methods The researchers in this study collected and sorted medical records on vertigo in seven books in accordance with the inclusion and exclusion criteria. After recording the frequency, four properties, five kinds of flavors, meridian entry and action classification of drugs, the researchers used the Origin 2022 software to draw radar charts of Chinese herbal medicine actions and medicinal properties. IBM SPSS Modeler 18.0 and Cytoscape 3.9.1 were used to display the core herbal medicine network, and the R 4.2.0 software was used to analyze and visualize the correlation and association rules. Additionally, SPSS Statistics 26.0 was used for cluster analysis of high-frequency drugs. Results A total of 178 medical records, 297 prescriptions and 289 Chinese herbal medicine data were collected for the management of vertigo. The total frequency was 3 684. Among them, the Chinese herbs were mainly tonics, liver-soothing drugs, heat-clearing drugs, exterior-relieving drugs and blood-activating and stasis-resolving drugs. The four properties of the herbs were mainly cold and warm, the distribution of the five kinds of flavor included mostly sweet, bitter and acrid the main meridians were the liver, spleen and lung. Thirty-seven herbs were used ≥ 30 times. The top forty drug pairs with high correlation coefficients were mostly tonics, blood-activating and stasis-resolving drugs and liver-soothing drugs. The most used two-drug pair was “Fossilia Mastodi Ossis and Concha Ostreae” and there were six groups of three-drug combinations. There were four new prescriptions for the management of vertigo. Conclusion The treatment of vertigo by the famous veteran Chinese medicine practitioners was mainly with liver-soothing drugs, qi and blood-nourishing drugs, phlegm-resolving and dampness-eliminating drugs, blood-activating and orifice-dredging drugs, and more, which reflect the basic principles of clinical management of dizziness. The study provides a theoretical basis for the research and development of clinical Chinese patent medicines and new drugs by exploring and analyzing the pattern of medication in the management of vertigo by famous veteran Chinese medicine practitioners, and helps to inherit and carry forward the valuable experience of vertigo treatment from famous veteran Chinese medicine practitioners.

Key words: Vertigo, Famous veteran Chinese medicine practitioner, Prescription rule, Core drug, Data mining

中图分类号: 

  • R276.1
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