特发性黄斑前膜患者神经节细胞复合体厚度与黄斑部深浅血流密度比值的相关性研究

doi:10.6040/j.issn.1673-3770.0.2022.322

摘要/Abstract

摘要： 目的观察并初步探讨特发性黄斑前膜(iERM)患者神经节细胞复合体(mGCC)厚度与黄斑部深浅血流密度比值(DSFR)的相关性。方法回顾性非随机对照临床实验研究。纳入武汉大学人民医院确诊为单眼iERM的24例患者为试验组,正常对侧眼为对照组。采用光学相干断层扫描(OCT)测量黄斑中心凹、旁中心凹以及中心凹周围区视网膜厚度,OCT的GCC模式测量mGCC厚度,眼底相干光层析血管成像测量黄斑区浅层视网膜毛细血管丛血流密度和深层视网膜毛细血管丛(DCP)血流密度并计算DSFR。 DSFR记录方式为ETDRS-Grid记录法。分析iERM组与对照组上述参数的统计学差异以及相关性。结果 iERM组OCT相关参数、mGCC相关参数与对侧眼对照组相比差异均具有统计学意义(P均<0.05);iERM组旁中心凹深浅血流密度比值(prDSFR)与mGCC平均厚度、上半部分厚度、下半部分厚度均具有显著相关性(r=-0.308,r=-0.263,r=-0.307,P均<0.05)。中心凹深浅血流密度比值与下半部分mGCC厚度具有显著相关性(r=-0.380,P<0.01)。mGCC平均厚度与浅层血管密度(SVD)、深层血管密度均无明显相关性,仅上半部分mGCC厚度与DCP层中心凹血流密度相关,下半部分mGCC厚度与SVD相关。D-MVR与mGCC平均厚度、上半部分mGCC厚度、下半部分mGCC厚度、prDSFR均具有显著相关性(r=0.434,r=0.521,r=0.341,r=0.295,P均<0.05)。结论 prDSFR、D-MVR与mGCC平均厚度显著相关,prDSFR与D-MVR也显著相关,推测iERM眼黄斑区结构的改变与血流存在显著关系。

关键词: 特发性黄斑前膜, 神经节细胞复合体, 血管密度, 深浅血流比:相关性

Abstract: Objective We monitored and investigated the correlation between the thickness of the macular ganglion cell complex(mGCC)and the ratio of deep to superficial vessel density(DSFR)in patients with idiopathic epiretinal membrane(iERM). Methods A retrospective, non-randomized, and controlled clinical study was conducted. Twenty-four patients diagnosed with monocular iERM at the Renmin Hospital of Wuhan University were included in the experimental group, with the normal contralateral eyes serving as the control group. Retinal thickness in the macular fovea, para-fovea, and peripheral area was measured by optical coherence tomography(OCT). In contrast, the thickness of the mGCC was measured using the GCC mode of OCT. The vessel density of the superficial retinal capillary plexus(SCP)and deep retinal capillary plexus(DCP)in the macular area was measured by optical coherence tomography angiography(OCTA). The DSFR was recorded using an ETDRS-GRIDrid recording. Statistical differences and correlations of the above parameters between the iERM and control groups were analyzed. Results OCT-related and mGCC-related parameters in the iERM group differed significantly from those in the contralateral eye control group(all P<0.05). The parafovea DSFR(pPrDSFR)of the experimental group was significantly correlated with the average GCC, Superior GCC, and Inferior GCC(r=-0.308, r=-0.263, and r=-0.307, respectively; all P<0.05). The fovea DSFR FDSFR was significantly correlated with the thickness of the Inferior GCC(r=-0.380, P<0.01). While the thickness of the average GCC was not significantly correlated with superficial vessel density(SVD)SVD and deep vessel densityDVD; however, the thickness of the Superior GCC was correlated with the foveal vessel densityFVD of the DCP, and the thickness of the Inferior GCC was correlated with SVD. D-MVR was significantly correlated with the average GCC thickness, superior GCC, inferior GCC, and prDSFR(r=0.434, r=0.521, r=0.341, r=0.295, all P<0.05). Conclusion We observed that prDSFR and D-MVR were significantly correlated with the thickness of the average GCC and that the prDSFR was also significantly correlated with D-MVR, suggesting a significant relationship between the structural changes in the macular area of iERM and vessel density.

Key words: Idiopathic epiretinal membrane, Macular ganglion cell complex, Vessel density, Deep to superficial vessel density, Correlation

中图分类号:

R774

雷敏,陈婷,艾明. 特发性黄斑前膜患者神经节细胞复合体厚度与黄斑部深浅血流密度比值的相关性研究[J]. 山东大学耳鼻喉眼学报, 2023, 37(2): 104-113.

LEI Min, CHEN Ting, AI Ming. Investigating the correlation between the macular ganglion cell complex and the ratio of deep and superficial vessel density in patients with idiopathic epiretinal membrane[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(2): 104-113.

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