山东大学耳鼻喉眼学报 ›› 2025, Vol. 39 ›› Issue (1): 1-7.doi: 10.6040/j.issn.1673-3770.0.2023.384
• 论著 •
郭振平1,2,3,李雪冰1,2
GUO Zhenping1,2,3, LI Xuebing1,2
摘要: 目的 探讨慢性主观性耳鸣(chronic subjective tinnitus, CST)患者的心理特征及睡眠质量,并分析其与临床效果的相关性。 方法 选入CST患者80例,采用抑郁自评量表(self-rating depression scale, SDS)、焦虑自评量表(self-rating anxiety scale, SAS)、匹兹堡睡眠质量指数(Pittsburgh sleep quality index, PSQI)评价患者的心理特征及睡眠质量,同时给予常规药物治疗,分析临床效果与心理特征及睡眠质量的相关性。 结果 随着听力下降程度加重,患者治疗前THI-C(F=28.255,P<0.001)、SDS(F=316.139,P<0.001)、SAS(F=204.933,P<0.001)、PSQI量表评分(F=220.602,P<0.001)均显著增加。正常听力与轻度聋(P=0.186),重度聋与极重度聋(P=0.09)患者中文版耳鸣残疾量表(Chinese version of the tinnitus handicap disability version, THI-C)评分比较无统计学意义,其他各听力程度组间均有统计学意义(P均<0.001)。高频耳鸣患者治疗前THI-C、SDS、SAS、PSQI量表评分显著高于低频和中频患者,中频患者则显著高于低频患者(F=48.950,P<0.001;F=225.048,P<0.001;F=230.489,P<0.001;F=332.730,P<0.001)。重度耳鸣患者治疗前SDS、SAS和PSQI量表评分显著高于轻度和中度患者,中度患者则显著高于轻度患者(P均<0.001)。治疗前THI-C评分与SDS、SAS和PSQI量表评分均有显著正相关性(r=0.649、0.681和0.657,P均<0.001)。80例患者治疗总有效率为63.75%,其中治愈21例、显效30例。患者治疗后THI-C(t=7.605,P<0.001)、SDS(t=25.344,P<0.001)、SAS(t=26.801,P<0.001)和PSQI量表评分(t=38.171,P<0.001)均显著低于治疗前,差异有统计学意义。治愈患者SDS(F=374.158,P<0.001)、SAS(F=577.547,P<0.001)和PSQI量表评分(F=570.382,P<0.001)显著低于显效和无效患者,显效患者则显著低于无效患者。 结论 CST患者存在普遍的抑郁、焦虑等负性情绪,睡眠质量较差,且其负性情绪和睡眠质量与耳鸣、听力程度有密切相关性,可对治疗效果造成不良影响。
中图分类号:
[1] Tinnitus Retraining Therapy Trial Research Group, Scherer RW, Formby C. Effect of tinnitus retraining therapy vs standard of care on tinnitus-related quality of life: a randomized clinical trial[J]. JAMA Otolaryngol Head Neck Surg, 2019, 145(7): 597-608. doi:10.1001/jamaoto.2019.0821 [2] Kim HJ, Lee HJ, An SY, et al. Analysis of the prevalence and associated risk factors of tinnitus in adults[J]. PLoS One, 2015, 10(5): e0127578. doi:10.1371/journal.pone.0127578 [3] 仝悦, 蒋雯, 吴扬, 等. 慢性主观性耳鸣精细化检查及多元复合声治疗初探[J]. 临床与病理杂志, 2019, 39(6): 1266-1272. doi:10.3978/j.issn.2095-6959.2019.06.019 TONG Yue, JIANG Wen, WU Yang, et al. Precision tinnitus testing for chronic subjective tinnitus and preliminarily analyses for the effect of multiple complex acoustic therapy[J]. Journal of Clinical and Pathological Research, 2019, 39(6): 1266-1272. doi:10.3978/j.issn.2095-6959.2019.06.019 [4] 孙慧颖, 冯国栋, 高志强. 声治疗在慢性主观性耳鸣中的临床应用现状[J]. 临床耳鼻咽喉头颈外科杂志, 2021, 35(3): 282-285. doi:10.13201/j.issn.2096-7993.2021.03.021 SUN Huiying, FENG Guodong, GAO Zhiqiang. Clinical application of sound therapy in chronic subjective tinnitus[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2021, 35(3): 282-285. doi:10.13201/j.issn.2096-7993.2021.03.021 [5] 李莉, 于文永. 慢性主观性耳鸣病人声治疗依从性影响因素的质性研究[J]. 全科护理, 2018, 16(13): 1593-1595. doi:10.12104/j.issn.1674-4748.2018.13.020 [6] 陈倬诣, 郑亿庆, 杨海弟. 慢性主观性耳鸣分类、发生发展机制及治疗新进展[J]. 山东大学耳鼻喉眼学报, 2023, 37(4): 1-12. doi:10.6040/j.issn.1673-3770.0.2023.137 CHEN Zhuoyi, ZHENG Yiqing, YANG Haidi. Classification, pathogenesis, and treatment advances of chronic subjective tinnitus[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(4): 1-12. doi:10.6040/j.issn.1673-3770.0.2023.137 [7] Park DH, Han SS, Han M, et al. A clinical trial of a patient-customized virtual reality intervention for tinnitus[J]. Sci Rep, 2022, 12(1): 12441. doi:10.1038/s41598-022-16764-5 [8] 石秋兰, 卜行宽, 王俊国, 等. 耳鸣致残量表中文版的研译与临床应用[J]. 南京医科大学学报(自然科学版), 2007, 27(5): 476-479. doi:10.3969/j.issn.1007-4368.2007.05.018 SHI Qiulan, BU Xingkuan, WANG Junguo, et al. Translation and application of tinnitus handicap inventory in Chinese version[J]. Journal of Nanjing Medical University(Natural Sciences), 2007, 27(5): 476-479. doi:10.3969/j.issn.1007-4368.2007.05.018 [9] 李斐然, 刘定, 徐红, 等. 耳鸣与脑源性神经营养因子关系的研究进展[J]. 中华耳科学杂志, 2020, 18(5): 967-971. doi:10.3969/j.issn.1672-2922.2020.05.031 LI Feiran, LIU Ding, XU Hong, et al. Progress in the study on relationship between tinnitus and brain-derived neurotrophic factor[J]. Chinese Journal of Otology, 2020, 18(5): 967-971. doi:10.3969/j.issn.1672-2922.2020.05.031 [10] Bhatt JM, Lin HW, Bhattacharyya N. Prevalence, severity, exposures, and treatment patterns of tinnitus in the United States[J]. JAMA Otolaryngol Head Neck Surg, 2016, 142(10): 959-965. doi:10.1001/jamaoto.2016.1700 [11] O'Brien DC, Robinson AD, Wang N, et al. Transdermal lidocaine as treatment for chronic subjective tinnitus: a pilot study[J]. Am J Otolaryngol, 2019, 40(3): 413-417. doi:10.1016/j.amjoto.2019.03.009 [12] 李青, 郭琳燕, 王维娜, 等. 慢性主观性耳鸣患者多元复合声治疗依从性的影响因素分析[J]. 中国医药导报, 2023, 20(15): 65-68. doi:10.20047/j.issn1673-7210.2023.15.13 LI Qing, GUO Linyan, WANG Weina, et al. Analysis of factors influencing compliance of patients with chronic subjective tinnitus treated with multiple complex sounds[J]. China Medical Herald, 2023, 20(15): 65-68. doi:10.20047/j.issn1673-7210.2023.15.13 [13] 王晓静, 董瑜新, 叶放蕾, 等. 认知行为疗法联合精细化护理对慢性主观性耳鸣患者的影响[J]. 深圳中西医结合杂志, 2022, 32(9): 127-130. doi:10.16458/j.cnki.1007-0893.2022.09.038 WANG Xiaojing, DONG Yuxin, YE Fanglei, et al. Effect of cognitive behavioral therapy combined with refined nursing on patients with chronic subjective tinnitus[J]. Shenzhen Journal of Integrated Traditional Chinese and Western Medicine, 2022, 32(9): 127-130. doi:10.16458/j.cnki.1007-0893.2022.09.038 [14] Monzani D, Genovese E, Pini LA, et al. Nimodipine in otolaryngology: from past evidence to clinical perspectives[J]. Acta Otorhinolaryngol Ital, 2015, 35(3): 135-145 [15] 董洪松, 王春丽, 俞艳萍, 等. 声音疗法联合药物治疗慢性主观性耳鸣的临床随机对照研究[J]. 山东大学耳鼻喉眼学报, 2023, 37(4): 30-37. doi:10.6040/j.issn.1673-3770.0.2023.210 DONG Hongsong, WANG Chunli, YU Yanping, et al. A randomized controlled clinical trial of sound therapy combined with medication in the treatment of chro-nic subjective tinnitus[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(4): 30-37. doi:10.6040/j.issn.1673-3770.0.2023.210 [16] 李颖, 冯国栋, 吴海燕, 等. 多个混合纯音频率声治疗对不同听力损失程度耳鸣患者有效性的双盲随机对照试验研究[J]. 中华耳鼻咽喉头颈外科杂志, 2019, 54(5): 355-361. doi:10.3760/cma.j.issn.1673-0860.2019.05.008 LI Ying, FENG Guodong, WU Haiyan, et al. A double-blind randomized controlled trial on the efficacy of mixed pure tone sound therapy in chronic tinnitus patients with different hearing loss[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2019, 54(5): 355-361. doi:10.3760/cma.j.issn.1673-0860.2019.05.008 [17] 朱晓月, 罗征, 孙越甲, 等. 主观性耳鸣患者心理人格特征研究[J]. 中国耳鼻咽喉头颈外科, 2022, 29(5): 301-303, 316. doi:10.16066/j.1672-7002.2022.05.007 ZHU Xiaoyue, LUO Zheng, SUN Yuejia, et al. Study on the psychologic status and personality traits of patients with tinnitus[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2022, 29(5): 301-303, 316. doi:10.16066/j.1672-7002.2022.05.007 [18] 郭岚宁, 齐音, 张艳利, 等. 影响慢性主观性耳鸣的心理学因素[J]. 心理学进展, 2022, 12(10): 3330-3335. doi:10.12677/ap.2022.1210404 GUO Lanning, QI Yin, ZHANG Yanli, et al. Psychological factors affecting chronic subjective tinnitus[J]. Advances in Psychology, 2022, 12(10): 3330-3335. doi:10.12677/ap.2022.1210404 [19] Weber FC, Schlee W, Langguth B, et al. Low sleep satisfaction is related to high disease burden in tinnitus[J]. Int J Environ Res Public Health, 2022, 19(17): 11005. doi:10.3390/ijerph191711005 [20] Wakabayashi S, Saito H, Oishi N, et al. Effects of tinnitus treatments on sleep disorders in patients with tinnitus[J]. Int J Audiol, 2018, 57(2): 110-114. doi:10.1080/14992027.2017.1374565 [21] 余力生, 马鑫. 耳鸣的代偿与失代偿[J]. 中华耳鼻咽喉头颈外科杂志, 2017, 52(8): 630-633. doi:10.3760/cma.j.issn.1673-0860.2017.08.019 YU Lisheng, MA Xin. Compensation and decompensation of tinnitus[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2017, 52(8): 630-633. doi:10.3760/cma.j.issn.1673-0860.2017.08.019 [22] LU Tao, LI Shuling, MA Ying, et al. Positive correlation between tinnitus severity and poor sleep quality prior to tinnitus onset: a retrospective study[J]. Psychiatr Q, 2020, 91(2): 379-388. doi:10.1007/s11126-019-09708-2 [23] 陈立萍, 黄超洋, 关志华, 等. 老年慢性主观性耳鸣严重程度与睡眠质量的相关性研究[J]. 华南国防医学杂志, 2016, 30(6): 376-378. doi:10.13730/j.issn.1009-2595.2016.06.006 CHEN Liping, HUANG Chaoyang, GUAN Zhihua, et al. Analysis of sleep quality in elderly patients with chronic subjective tinnitus[J]. Military Medical Journal of South China, 2016, 30(6): 376-378. doi:10.13730/j.issn.1009-2595.2016.06.006 [24] 齐柳, 宋勇莉, 白雪, 等. 慢性主观性耳鸣患者睡眠障碍及影响因素分析[J]. 中国眼耳鼻喉科杂志, 2022, 22(2): 119-123. doi:10.14166/j.issn.1671-2420.2022.02.003 QI Liu, SONG Yongli, BAI Xue, et al. Analysis of sleep disturbance and its influencing factors in patients with chronic subjective tinnitus[J]. Chinese Journal of Ophthalmology and Otorhinolaryngology, 2022, 22(2): 119-123. doi:10.14166/j.issn.1671-2420.2022.02.003 [25] 鹿艳丽. 探究认知行为疗法(CBT)结合精细化护理对慢性主观性耳鸣患者睡眠质量、心理状态及应对方式的影响[J].医药卫生, 2023,(1): 148-151 |
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