山东大学耳鼻喉眼学报 ›› 2015, Vol. 29 ›› Issue (1): 8-11.doi: 10.6040/j.issn.1673-3770.0.2014.223

• 睡眠呼吸障碍性疾病 • 上一篇    下一篇

脑源性神经营养因子与睡眠呼吸暂停综合征的相关性

张婵娟 综述, 李延忠, 王岩 审校   

  1. 山东大学齐鲁医院耳鼻咽喉科/山东大学卫生部耳鼻咽喉科学重点实验室, 山东 济南 250012
  • 收稿日期:2014-07-02 出版日期:2015-02-16 发布日期:2015-02-16
  • 通讯作者: 李延忠。E-mail:liyanzhong@sdu.edu.cn;王岩。E-mail:wangyan66@sdu.edu.cn E-mail:liyanzhong@sdu.edu.cn;wangyan66@sdu.edu.cn
  • 作者简介:张婵娟。E-mail:283616833@qq.com

The relationship between brain derived neurotrophic factor and obstructive sleep apnea syndrome

ZHANG Chan-juan, LI Yan-zhong, WANG Yan   

  1. Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Key Laboratory of Otorhinolaryngology of Health Ministry, Jinan 250012, Shandong, China
  • Received:2014-07-02 Online:2015-02-16 Published:2015-02-16

摘要: 阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是一种严重危害人类健康的慢性睡眠呼吸疾病,可累及心血管、神经、代谢及内分泌等全身多个系统及器官,引起一系列的并发症。脑源性神经营养因子(BDNF)是由脑组织合成的一种蛋白质,在神经营养因子家族中含量最多、分布最广,近年来研究较多。越来越多证据表明,BDNF在OSAHS很多并发症中表达常有异常。论文总结最新的研究成果,对BDNF在OSAHS并发的多个系统及器官疾病中的可能作用机制进行综述,为后续研究拓宽可能存在的线索。

关键词: 睡眠呼吸暂停综合征, 发病机制, 脑源性神经营养因子

Abstract: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a serious, chronic sleep breathing disorder. OSAHS may affect the cardiovascular, nervous, and endocrine systems, resulting in series of concurrent symptoms. Brain-derived neurotrophic factor (BDNF) is a protein produced by brain tissues. BDNF is the most abundant and widely distributed member of the neurotrophic factor family. Recent years, a number of studies suggested that the expression of BDNF was often abnormal in OSAHS. This paper summarizes the latest research results, and the role of BDNF in the pathogenesis mechanism will be reviewed to bring up the possible clues for further study.

Key words: Pathogenesis, Obstructive sleep apnea-hypopnea syndrome, Brain-derived neurotrophic factor

中图分类号: 

  • R766.7
[1] Peppard P E, Young T, Palta M, et al. Prospective study of the association between sleep-disordered breathing and hypertension[J]. N Engl J Med, 2000, 342(19): 1378-1384.
[2] Harsch l A, Schahin S P, Radespiel-Troger M, et al. CPAP treatment rapidly improves insulin sensitivity in patients with obstructive sleep apnea syndrome[J]. Am J Respir Crit Care Med, 2004, 169(2): 156-162.
[3] 王卫红.OSAHS对认知功能的影响及相关[D].长沙:中南大学,2012. WANG Weihong. Cognitive imparirment in OSAHSpatients and its related mechanism[D]. Changsha:Central South University, 2012.
[4] Zhou X P, Wu K Y, Liang B, et al. TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis[J]. Proc Natl Acad Sci U S A, 2008, 105(44):17181-17186.
[5] Pereira A C, Huddleston D E, Brickman A M, et al. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus[J]. Proc Natl Acad Sci U S A, 2007, 104(13):5638-5643.
[6] McHughen S A, Rodriguez P F, Kleim J A, et al. BDNF val66met polymorphism influences motor system function in the human brain[J]. Cereb Cortex, 2010, 20(5):1254-1262.
[7] McHughen S A, Rodriguez P F, Kleim J A, et al. BDNF val66met polymorphism influences motor system function in the human brain[J]. Cereb Cortex, 2010, 20(5):1254-1262.
[8] Kamba M, Inoue Y, Higami S, et al. Cerebral metabolic impairment in patients with sleep apnoea: an independent association of obstructive sleep apnoea with white matter change[J]. J Neurol Neurosurg Psychiatry, 2001, 71(3):334-339.
[9] Ji Y, Pang P T, Feng L, et al. Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons[J]. Nat Neurosci, 2005, 8(2):164-172.
[10] Li Y, Jia Y C, Cui K, et al. Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor[J]. Nature, 2005, 434(7035):894-898.
[11] Zhou J, Du W, Zhou K, et al. Critical role of TRPC6 channels in the formation of excitatory synapses[J]. Nat Neurosci, 2008, 11(7):741-743.
[12] Gosselin N, Mathieu A, Mazza S, et al. Attentional deficits in patients with obstructive sleep apnea syndrome:an event related potential study[J]. Clin Neurophysiol, 2006, 117(10):2228-2235.
[13] Bawden F C, Oliveira C A, Caramelli P. Impact of obstructive sleep apnea on cognitive performance[J]. Arquivos De Neuro-Psiquiatia, 2011, 69(4)585-589.
[14] Knipper M, Berzaghi M P, Blochl A, et al. Positive feed back between acetyl choline and the neurotrophins nerve growth factor and brain derived neurotrophic factor in the rat hippocampus[J]. Eur J Neuroci, 1994, 6(2):668-671.
[15] Messaoudi E, Barsen K, Srebro B, et al. Acute intrahippocampal in fusion of BDNF induces lasting potentiation of synaptic transmission in the rat dentate gyrus[J]. J Neurophysiol, 1998, 79(1):496-499.
[16] Jiang Q S, Liang Z L, Wu M J, et al. Reduced brain-derived neurotrophic factor expression in cortex and hippocampus involved in the learning and memory deficit in molarless SAMPS mice[J]. Chin Med J (Engl), 2011, 4(10):1540-1544.
[17] Laring K, Mitchell D, Wersching H, et al. Brain-derived neurotrophic factor (BDNF) gene: a gender-specific role in cognitive function during normal cognitive aging of the MEMO-Study?[J]. Age (Dorde), 2012,34(4):1011-1022.
[18] Worsnop C, Kay A, Pierce R, et al. Activity of respiratory pump and upper airway muscles during sleep onset[J]. J Appl Physiol, 1998, 85(3):908-920.
[19] Svanborg E. Impact of obstructive apnea syndrome on upper airway respiratory muscles[J]. Respir Physiol Neurobiol, 2005, 147(2-3):263-272.
[20] Caravagna C, Soliz J, Seaborn T. Brain-derived neurotrophic factor interacts with astrocytes and neurons to control respiration[J]. Eur J Neurosci, 2013, 38(9):3261-3269.
[21] Saunamki T, Jenkonen M. Depression and anxiety in obstructive sleep apnea syndrome: a review[J]. Acta Neurol Scand, 2007, 116 (5):277-288.
[22] 韩建芳.男性阻塞性睡眠呼吸暂停综合征患者性激素研究[D].广州:南方医科大学,2013. HAN Jianfang. Sex hormone changes in male patients with obstructive sleep apnea hypopnea syndrome[D]. Guangzhou: Southern Medical University, 2013.
[23] 王春强.神经营养素-4及其受体在牛成熟精子和支持细胞中的表达与功能研究[D].长春:吉林大学,2013. WANG Chunqiang. Expyession and function of neurotrophin-4 and its receptor in bovin mature spermatozoa and Sertoli cells[D]. Changchun: Jilin University, 2013.
[24] Barde Y A, Edgar D, Thoenen H. Purification of a new neurotrophic factor from mamalian brain[J]. EMBO J, 1982, 1(5):549-553.
[25] Friedel S, Horro F F,Wermter A K, et al. Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit hyperactivity disorder[J]. Am J Med Genet B Neuropsychiatr Genet, 2005, 132B(1):96-99.
[26] Nakazato M, Hashimoto K, Shimizu E, et al. Decreased levels of serum brain-derived neurotrophic factor in female patients with eating disorders[J]. Biol Psychiatry, 2003, 54(4):485-490.
[27] Hirsch S, Labes M, Bhr M. Changes in BDNF and neurotrophin receptor expression in degenerating and regenerating rat retinal ganglion cells[J]. Restor Neurol Neurosci, 2000, 17(2-3):125-134.
[1] 刘大炜,张宇,李成林,陈秀梅,宋西成. 加速康复外科在儿童OSAS围手术期中的应用[J]. 山东大学耳鼻喉眼学报, 2018, 32(5): 19-22.
[2] 李华斌, 赖玉婷. 慢性鼻-鼻窦炎的发病机制及诊疗进展[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 4-9.
[3] 薛荣,张希龙. 咽部肌肉和结构与阻塞性睡眠呼吸暂停的关系[J]. 山东大学耳鼻喉眼学报, 2016, 30(5): 9-12.
[4] 章如新. 变应性鼻炎的研究进展[J]. 山东大学耳鼻喉眼学报, 2016, 30(4): 3-6.
[5] 刘哲综述, 滕博,文连姬审校. 室内空气污染物及饮食结构对变应性疾病的影响[J]. 山东大学耳鼻喉眼学报, 2016, 30(3): 96-102.
[6] 杨梓超, 王育良. 眼干燥症的病因、发病机制及中西医结合治疗进展[J]. 山东大学耳鼻喉眼学报, 2015, 29(2): 91-93.
[7] 卢振东1,杨军2. 听觉剥夺和耳蜗内电刺激引起幼鼠听觉通路bdnf和c-fos基因及蛋白改变[J]. 山东大学耳鼻喉眼学报, 2012, 26(3): 17-23.
[8] 张华,张庆泉. UPPP手术的并发症及其防治[J]. 山东大学耳鼻喉眼学报, 2012, 26(1): 12-14.
[9] 汪新1综述, 魏伟2审校. 弱视发病机制的多焦电生理及影像学研究现状[J]. 山东大学耳鼻喉眼学报, 2011, 25(1): 68-71.
[10] 王风娟综述,范献良审校. 脂肪细胞脂肪酸结合蛋白与阻塞性睡眠呼吸暂停综合征及糖尿病的关系[J]. 山东大学耳鼻喉眼学报, 2010, 24(2): 67-70.
[11] 朱子诚,柯根杰,潘红飙. 超声生物显微镜在青少年挫伤性近视发病机制的应用研究[J]. 山东大学耳鼻喉眼学报, 2010, 24(01): 54-.
[12] 翁永彩,刘吉祥,王 林 . UPPP手术对阻塞性睡眠呼吸暂停低通气综合征患者血清hs-CRP的影响[J]. 山东大学耳鼻喉眼学报, 2007, 21(5): 400-403 .
[13] 徐乐昕,郭 星,宁 博 . 悬雍垂腭咽成形术治疗阻塞性睡眠呼吸暂停低通气综合征59例[J]. 山东大学耳鼻喉眼学报, 2007, 21(5): 411-414 .
[14] 徐福杰,卢爱君 . 阻塞性睡眠呼吸暂停低通气综合征患者腭咽成形术后并发症发生率对比分析[J]. 山东大学耳鼻喉眼学报, 2007, 21(4): 307-308 .
[15] 王卫之,马建玲,刘 洁,张代杰 . 不同年龄阻塞性睡眠呼吸暂停低通气综合征患者的睡眠监测[J]. 山东大学耳鼻喉眼学报, 2007, 21(2): 155-157 .
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!