脑源性神经营养因子与睡眠呼吸暂停综合征的相关性

doi:10.6040/j.issn.1673-3770.0.2014.223

摘要/Abstract

摘要： 阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是一种严重危害人类健康的慢性睡眠呼吸疾病,可累及心血管、神经、代谢及内分泌等全身多个系统及器官,引起一系列的并发症。脑源性神经营养因子(BDNF)是由脑组织合成的一种蛋白质,在神经营养因子家族中含量最多、分布最广,近年来研究较多。越来越多证据表明,BDNF在OSAHS很多并发症中表达常有异常。论文总结最新的研究成果,对BDNF在OSAHS并发的多个系统及器官疾病中的可能作用机制进行综述,为后续研究拓宽可能存在的线索。

关键词: 睡眠呼吸暂停综合征, 发病机制, 脑源性神经营养因子

Abstract: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a serious, chronic sleep breathing disorder. OSAHS may affect the cardiovascular, nervous, and endocrine systems, resulting in series of concurrent symptoms. Brain-derived neurotrophic factor (BDNF) is a protein produced by brain tissues. BDNF is the most abundant and widely distributed member of the neurotrophic factor family. Recent years, a number of studies suggested that the expression of BDNF was often abnormal in OSAHS. This paper summarizes the latest research results, and the role of BDNF in the pathogenesis mechanism will be reviewed to bring up the possible clues for further study.

Key words: Pathogenesis, Obstructive sleep apnea-hypopnea syndrome, Brain-derived neurotrophic factor

中图分类号:

R766.7

张婵娟 , 李延忠, 王岩 . 脑源性神经营养因子与睡眠呼吸暂停综合征的相关性[J]. 山东大学耳鼻喉眼学报, 2015, 29(1): 8-11.

ZHANG Chan-juan, LI Yan-zhong, WANG Yan. The relationship between brain derived neurotrophic factor and obstructive sleep apnea syndrome[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(1): 8-11.

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