谷氧还蛋白在眼病中的作用研究进展

doi:10.6040/j.issn.1673-3770.0.2020.191

摘要/Abstract

摘要： 谷氧还蛋白(Grx)是巯基-二硫化物氧化还原酶家族的重要一员,其主要功能是还原蛋白质和谷胱甘肽形成的二硫化物,从而维持细胞的氧化还原平衡。Grx存在于全身许多组织中。近年来,Grx在眼部疾病中发挥的保护功能和与其他抗氧化酶的协同作用不断被阐明,对于Grx有了更加深入的认识。综述主要总结了Grx在治疗眼病研究中所取得的最新进展。

关键词: 谷氧还蛋白, 氧化应激, 抗氧化酶, 白内障, 眼病, 基因敲除小鼠

Abstract: Glutaredoxin(Grx)is animportant member of the thiol disulfide oxidoreductase protein family. The primary function is to dethiolate glutathionylated proteins, thus maintaining cellular redox homeostasis. Grx is expressed in many tissues throughout the body. In recent years, the protective function of Grx in oculopathy and its synergistic effect with other antioxidative enzymes have been increasingly elucidated, leading to a better understanding of this protein. This review summarizes the latest research on the role of Grx in oculopathy.

Key words: Glutaredoxin, Oxidative stress, Antioxidase, Cataract, Oculopathy, Gene knockout mice

中图分类号:

付奕豪,徐逸轩,严宏,张婕. 谷氧还蛋白在眼病中的作用研究进展[J]. 山东大学耳鼻喉眼学报, 2021, 35(3): 125-130.

FU Yihao, XU Yixuan,YAN Hong, ZHANG Jie. Recent research advances in the role of glutaredoxin in oculopathy[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(3): 125-130.

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