慢性鼻窦炎伴鼻息肉患者血清25-(OH)D3和组织中TGF-β1水平及临床意义

doi:10.6040/j.issn.1673-3770.0.2020.536

摘要/Abstract

摘要： 目的探讨慢性鼻窦炎伴鼻息肉(CRSwNP)患者的血清25-(OH)D₃水平和鼻息肉组织中转化生长因子-β1(TGF-β₁)表达及相关性。方法收集住院手术并经病理诊断为慢性鼻窦炎伴鼻息肉患者47例为实验组,并以上颌窦囊肿患者21例为对照组。统计并比较两组患者血清25-(OH)D₃水平和鼻息肉组织中TGF-β₁平均光密度值,及两者之间相关性。结果实验组患者血清25-(OH)D₃水平(16.97±7.35 μg/L)低于对照组患者(22.07±11.60 μg/L),差异有统计学意义(P=0.032);组织中TGF-β₁平均光密度值(0.052 4±0.019 1)高于对照组患者(0.041 0±0.014 5),差异有统计学意义(P=0.018)。CRSwNP患者血清25-(OH)D₃水平和鼻息肉组织中TGF-β₁表达具有一定相关性(R2=0.204,∣R∣=0.452,P=0.019)。结论 CRSwNP患者血清25-(OH)D₃水平降低,而鼻息肉组织中TGF-β₁表达升高,并且二者在CRSwNP中具有一定相关性。

关键词: 25-羟维生素D3, 转化生长因子-β1, 鼻息肉, 慢性鼻窦炎, 上颌窦囊肿, 光密度值

Abstract: Objective To investigate the relationship between serum 25-(OH)D₃ levels and transforming growth factor-β₁(TGF-β₁)expression in patients with chronic rhinosinusitis with nasal polyps(CRSwNP). Methods Forty-seven patients with CRSwNP who were diagnosed by pathology were selected as an observation group and 21 patients with maxillary sinus cysts were selected as the control group. The level of serum 25-(OH)D₃ and the mean optical density of TGF-β₁ in the tissue samples were compared between the two factors. Results The level of serum 25-(OH)D₃ in the observation group(16.97±7.35 μg/L)was lower than that in the control group(22.07±11.60 μg/L), the difference was statistically significant (P=0.032); the mean optical density of the TGF-β₁ in the nasal polyps(0.052 4±0.019 1)was higher in the observation group than the control group(0.041 0±0.014 5); the difference was statistically significant(P=0.018). There was a significant correlation between serum 25-(OH)D₃ levels and TGF-β₁ expression in the nasal polyps(R2=0.204,|R|=0.452, P=0.019). Conclusion The level of serum 25-(OH)D₃ in patients with CRSwNP decreased, while the expression of TGF-β₁ in the nasal polyps increased, and there was a significant correlation between them in CRSwNP.

Key words: 25-(OH)D₃, Transforming growth factor-β1, Chronic rhinosinusitis with nasal polyps, Chronic rhinosinusitis, Maxillary sinus cyst, Optical density value

中图分类号:

R765.4

韩佳琦,苑国庆,朱宇彤,姜菲菲,阎艾慧. 慢性鼻窦炎伴鼻息肉患者血清25-(OH)D₃和组织中TGF-β₁水平及临床意义[J]. 山东大学耳鼻喉眼学报, 2021, 35(5): 23-27.

HAN Jiaqi, YUAN Guoqing, ZHU Yutong, JIANG Feifei, YAN Aihui. Serum 25-(OH)D₃ and tissue TGF-β₁ levels in patients with chronic rhino sinusitis with nasal polyps and their clinical significance[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(5): 23-27.

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慢性鼻窦炎伴鼻息肉患者血清25-(OH)D₃和组织中TGF-β₁水平及临床意义

Serum 25-(OH)D₃ and tissue TGF-β₁ levels in patients with chronic rhino sinusitis with nasal polyps and their clinical significance

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