山东大学耳鼻喉眼学报 ›› 2024, Vol. 38 ›› Issue (3): 55-60.doi: 10.6040/j.issn.1673-3770.0.2023.504
• 论著 • 上一篇
鲍莹1,2,刘志高2,姜鹏飞3,崔文轩1,郑晓霞1,杨梦瑶1,司明威1,王玉2,4,王红1
BAO Ying1,2, LIU Zhigao2, JANG Pengfei3, CUI Wenxuan1, ZHENG Xiaoxia1, YANG Mengyao1, SI Mingwei1, WANG Yu2,4, WANG Hong1
摘要: 目的 观察康柏西普治疗糖尿病合并非缺血型视网膜中央静脉阻塞伴黄斑水肿(central retinal vein occlusion-macular edema, CRVO-ME)患者视网膜层间高反射点(hyperreflective dots, HRD)的变化。 方法 选取非缺血型CRVO-ME患者80例80眼,根据有无糖尿病分为糖尿病组40例(40眼)、非糖尿病组40例(40眼),对比分析两组患者玻璃体腔注射康柏西普(intravitreal injection of conbercept, IVC)治疗前及治疗后1、3、6个月的最佳矫正视力(best-corrected visual acuity, BCVA)、黄斑中心凹厚度(central macular thickness, CMT)、视网膜内外层HRD数量。 结果 IVC治疗后3、6个月时,非糖尿病组BCVA较糖尿病组明显提高(F=4.106,P=0.046;F=10.474,P=0.002);IVC治疗后6个月时,CMT明显降低(F=10.688,P=0.002)。两组IVC治疗前后视网膜内层HRD数量差异无统计学意义(F=1.608,P=0.209),视网膜外层HRD数量差异有统计学意义(F=4.290,P=0.042)。 结论 IVC对非缺血型CRVO-ME疗效明显。视网膜外层HRD可以作为监测炎症反应、评估预后的影像学指标。糖尿病组患者发生非缺血型CRVO-ME后,远期治疗效果较非糖尿病组差,因此,更要重视糖尿病患者的长期随访观察,避免严重并发症的发生。
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