山东大学耳鼻喉眼学报 ›› 2024, Vol. 38 ›› Issue (2): 103-108.doi: 10.6040/j.issn.1673-3770.0.2023.024
李淑婷,赵慧,司明威,崔文轩,杨梦瑶,王红
LI Shuting, ZHAO Hui, SI Mingwei, CUI Wenxuan, YANG Mengyao, WANG Hong
摘要: 目的 探究1例无植物性外伤史且诊断为真菌性眼内炎合并糖尿病患者的发病原因。 方法 1例53岁男性患者因左眼视力急剧下降于外院进行糖皮质激素冲击治疗后无明显改善,15 d后来山东大学齐鲁医院眼科进行眼内液检测以明确致病菌,行左眼白内障超声乳化+玻璃体切割+眼内激光+硅油填充+玻璃体腔注药(伏立康唑0.02 mg)术。 结果 术后玻璃体液送检染色:真菌(-);矫正视力:右眼0.1,左眼 HM/5 cm;眼前后节情况稳定。 结论 镰刀菌是免疫低下患者内源性眼内炎的一种罕见但公认的病因,其感染途径多样,糖尿病及类固醇激素的应用可降低患者免疫系统稳定性,及时的诊断及抗真菌治疗对患者的预后非常重要。
中图分类号:
[1] | Sowik M, Biernat MM, Urbaniak-Kujda D, et al. Mycotic infections of the eye[J]. Adv Clin Exp Med, 2015, 24(6): 1113-1117. doi:10.17219/acem/50572 |
[2] | 张文华, 潘志强, 王智群, 等. 化脓性角膜溃疡常见致病菌的变迁[J]. 中华眼科杂志, 2002(1): 8-12. doi:10.3760/j: issn: 0412-4081.2002.01.004 ZHANG Wenhua, PAN Zhiqiang, WANG Zhiqun, et al. The variance of pathogenic organisms of purulent ulcerative keratitis[J]. Chinese Journal of Ophthalmology, 2002(1): 8-12. doi:10.3760/j: issn: 0412-4081.2002.01.004 |
[3] | 王丽娅, 张月琴, 王印其, 等. 中国三地区真菌性角膜病致病菌种的调查[J]. 中华眼科杂志, 2000(2): 138-140. doi:10.3760/j: issn: 0412-4081.2000.02.017 WANG Liya, ZHANG Yueqin, WANG Yinqi, et al. Spectrum of mycotic keratitis in China[J]. Chinese Journal of Ophthalmology, 2000(2): 138-140. doi:10.3760/j: issn: 0412-4081.2000.02.017 |
[4] | Xie LX, Shi WY, Liu ZS, et al. Lamellar keratoplasty for the treatment of fungal keratitis[J]. Cornea, 2002, 21(1): 33-37. doi:10.1097/00003226-200201000-00008 |
[5] | Xie L, Dong X, Shi W. Treatment of fungal keratitis by penetrating keratoplasty[J]. Br J Ophthalmol, 2001, 85(9): 1070-1074. doi:10.1136/bjo.85.9.1070 |
[6] | 孙士营,赵格,孙晓艳,等.真菌性眼内炎常见病因及致病菌种分析[J].中华眼科杂志, 2014, 50(11): 808-813. doi:10.3760/cma.j.issn.0412-4081.2014.11.003 SUN Shiying, ZHAO Ge, SUN Xiaoyan, et al. Analysis of common causes and pathogenic species of fungal endophthalmitis[J]. Chinese Journal of Ophthalmology, 2014, 50(11): 808-813. doi:10.3760/cma. J. issn. 0412-4081.2014.11.003 |
[7] | Lingappan A, Wykoff CC, Albini TA, et al. Endogenous fungal endophthalmitis: causative organisms, management strategies, and visual acuity outcomes[J]. Am J Ophthalmol, 2012,153(1): 162-166. doi: 10.1016/j.ajo.2011.06.020 |
[8] | 李曼,王艳玲,赵露.白内障术后粪肠球菌眼内炎1例并文献复习[J].山东大学耳鼻喉眼学报, 2022, 36(6): 56-59. doi:10.6040/j.issn.1673-3770.02021.187 LI Man, WANG Yanling, ZHAO Lu. A case of Enterococcus faecalis endophthalmitis after cataract surgery and review of the literature [J]. Journal of Otolaryngology and Ophthalmology, Shandong University, 2022, 36(6): 56-59. doi:10.6040/j.issn.1673-3770.02021.187 |
[9] | Clarke B, Williamson TH, Gini G, et al. Management of bacterial postoperative endophthalmitis and the role of vitrectomy[J]. Surv Ophthalmol, 2018, 63(5): 677-693. doi:10.1016/j.survophthal.2018.02.003 |
[10] | Relhan N, Forster RK, Flynn HW. Endophthalmitis: then and now[J]. Am J Ophthalmol, 2018, 187: xx-xxvii. doi:10.1016/j.ajo.2017.11.021 |
[11] | Jackson TL, Paraskevopoulos T, Georgalas I. Systematic review of 342 cases of endogenous bacterial endophthalmitis[J]. Surv Ophthalmol, 2014, 59(6): 627-635. doi:10.1016/j.survophthal.2014.06.002 |
[12] | Connell PP, O'Neill EC, Fabinyi D, et al. Endogenous endophthalmitis: 10-year experience at a tertiary referral centre[J]. Eye(Lond), 2011, 25(1): 66-72. doi:10.1038/eye.2010.145 |
[13] | Connell PP, O'Neill EC, Amirul Islam FM, et al. Endogenous endophthalmitis associated with intravenous drug abuse: seven-year experience at a tertiary referral center[J]. Retina, 2010, 30(10): 1721-1725. doi:10.1097/IAE.0b013e3181dd6db6 |
[14] | Vaziri K, Pershing S, Albini TA, et al. Risk factors predictive of endogenous endophthalmitis among hospitalized patients with hematogenous infections in the UnitedStates[J]. Am J Ophthalmol, 2015, 159(3): 498-504. doi:10.1016/j.ajo.2014.11.032 |
[15] | Sridhar J, Flynn HW Jr, Kuriyan AE, et al. Endogenous fungal endophthalmitis: risk factors, clinical features, and treatment outcomes in mold and yeast infections[J]. J Ophthalmic Inflamm Infect, 2013, 3(1): 60. doi:10.1186/1869-5760-3-60 |
[16] | Keyashian K, Malani PN. Endophthalmitis associated with intravenous drug use[J]. South Med J, 2007, 100(12): 1219-1220. doi:10.1097/SMJ.0b013e3181581191 |
[17] | Patel SN, Rescigno RJ, Zarbin MA, et al. Endogenous endophthalmitis associated with intravenous drug abuse[J]. Retina, 2014, 34(7): 1460-1465. doi:10.1097/IAE.0000000000000084 |
[18] | Shrader SK, Band JD, Lauter CB, et al. The clinical spectrum of endophthalmitis: incidence, predisposing factors, and features influencing outcome[J]. J Infect Dis, 1990, 162(1): 115-120. doi:10.1093/infdis/162.1.115 |
[19] | Binder MI, Chua J, Kaiser PK, et al. Endogenous endophthalmitis: an 18-year review of culture-positive cases at a tertiary care center[J]. Medicine, 2003, 82(2): 97-105. doi:10.1097/00005792-200303000-00004 |
[20] | Cho H, Shin YU, Siegel NH, et al. Endogenous endophthalmitis in the American and Korean population: an 8-year retrospective study[J]. Ocul Immunol Inflamm, 2018, 26(4): 496-503. doi:10.1080/09273948.2016.1195000 |
[21] | Jørgensen JS, Prause JU, Kiilgaard JF. Bilateral endogenous Fusarium solani endophthalmitis in a liver-transplanted patient: a case report[J]. J Med Case Rep, 2014, 8: 101. doi: 10.1186/1752-1947-8-101 |
[22] | Lieberman TW, Ferry AP, Bottone EJ. Fusarium solani endophthalmitis without primary corneal involvement[J]. Am J Ophthalmol, 1979, 88(4): 764-767. doi: 10.1016/0002-9394(79)90680-9 |
[23] | Kumar KK, Sampritha UC, Prakash AA, et al. Ophthalmic manifestations in the COVID-19 clinical spectrum[J]. Indian J Ophthalmol, 2021, 69(3): 691-694. doi:10.4103/ijo.IJO_3037_20 |
[24] | Sheth JU, Narayanan R, Goyal J, et al. Retinal vein occlusion in COVID-19: a novel entity[J]. Indian J Ophthalmol, 2020, 68(10): 2291-2293. doi:10.4103/ijo.IJO_2380_20 |
[25] | Dumitrascu OM, Volod O, Bose S, et al. Acute ophthalmic artery occlusion in a COVID-19 patient on apixaban[J]. J Stroke Cerebrovasc Dis, 2020, 29(8): 104982. doi:10.1016/j.jstrokecerebrovasdis.2020.104982 |
[26] | Virgo J, Mohamed M. Paracentral acute middle maculopathy and acute macular neuroretinopathy following SARS-CoV-2 infection[J]. Eye(Lond), 2020, 34(12): 2352-2353. doi:10.1038/s41433-020-1069-8 |
[27] | Shroff D, Narula R, Atri N, et al. Endogenous fungal endophthalmitis following intensive corticosteroid therapy in severe COVID-19 disease[J]. Indian J Ophthalmol, 2021, 69(7): 1909-1914. doi:10.4103/ijo.IJO_592_21 |
[28] | Yang L, Gou JJ, Gao JB, et al. Immune characteristics of severe and critical COVID-19 patients[J]. Signal Transduct Target Ther, 2020, 5(1): 179. doi:10.1038/s41392-020-00296-3 |
[29] | Chalmers JD, Crichton ML, Goeminne PC, et al. Management of hospitalised adults with coronavirus disease 2019(COVID-19): a European Respiratory Society living guideline[J]. Eur Respir J, 2021, 15, 57(4): 2100048. doi: 10.1183/13993003.50048-2021 |
[30] | Lim HW, Shin JW, Cho HY, et al. Endogenous endophthalmitis in the Korean population: a six-year retrospective study[J]. Retina, 2014, 34(3): 592-602. doi:10.1097/IAE.0b013e3182a2e705 |
[31] | Wong JS, Chan TK, Lee HM, et al. Endogenous bacterial endophthalmitis: an East Asian experience and a reappraisal of a severe ocular affliction[J]. Ophthalmology, 2000, 107(8): 1483-1491. doi:10.1016/s0161-6420(00)00216-5 |
[32] | Coburn PS, Wiskur BJ, Christy E, et al. The diabetic ocular environment facilitates the development of endogenous bacterial endophthalmitis[J]. Invest Ophthalmol Vis Sci, 2012, 53(12): 7426-7431. doi:10.1167/iovs.12-10661 |
[33] | Chongkae S, Youngchim S, Nosanchuk JD, et al. Fungal keratitis in northern Thailand: spectrum of agents, risk factors and putative virulence factors[J]. J Fungi(Basel), 2021, 7(6): 475. doi:10.3390/jof7060475 |
[34] | Sahay P, Goel S, Nagpal R, et al. Infectious keratitis caused by rare and emerging micro-organisms[J]. Curr Eye Res, 2020, 45(7): 761-773. doi:10.1080/02713683.2019.1708407 |
[35] | Maitray A, Rishi E, Rishi P, et al. Endogenous endophthalmitis in children and adolescents: case series and literature review[J]. Indian J Ophthalmol, 2019, 67(6): 795-800. doi:10.4103/ijo.IJO_710_18 |
[36] | 王文吉. 内源性真菌性眼内炎[J]. 中国眼耳鼻喉科杂志, 2018, 18(2): 82-84. doi:10.14166/j.issn.1671-2420.2018.02.003 WANG Wenji. Endogenous fungal endophthalmitis[J]. Chinese Journal of Ophthalmology and Otorhinolaryngology, 2018, 18(2): 82-84. doi:10.14166/j.issn.1671-2420.2018.02.003 |
[1] | 周静琳,李金香,曾琦. 577 nm阈值下微脉冲激光联合抗VEGF药物治疗难治性糖尿病性黄斑水肿的疗效观察[J]. 山东大学耳鼻喉眼学报, 2024, 38(2): 18-25. |
[2] | 何静,雷春燕,张美霞. 糖化血红蛋白变异指数与糖尿病视网膜病变严重程度的相关性研究[J]. 山东大学耳鼻喉眼学报, 2024, 38(2): 34-40. |
[3] | 伦英俊,陈晨,高宏程,范清琳,邰仁清. TLR4/NF-κB通道在糖尿病视网膜病变中的作用[J]. 山东大学耳鼻喉眼学报, 2024, 38(2): 163-168. |
[4] | 王丽雪,曾毅,王丽欣,彭先兵. 浸润毕罗芬明胶海绵在功能性鼻内镜鼻窦手术后应用效果的临床观察[J]. 山东大学耳鼻喉眼学报, 2023, 37(5): 16-25. |
[5] | 卢淦,邓玉琴,陶泽璋. 过敏性疾病与糖尿病的相关性及潜在关联机制[J]. 山东大学耳鼻喉眼学报, 2023, 37(5): 215-222. |
[6] | 唐慧新,李景景,邹红. 阈值下微脉冲激光光凝作用机制及临床应用[J]. 山东大学耳鼻喉眼学报, 2023, 37(3): 143-148. |
[7] | 李聪,李玲,刘亭彦, 陈良. 氨基糖苷类抗生素耳毒性影响因素研究进展[J]. 山东大学耳鼻喉眼学报, 2023, 37(2): 128-134. |
[8] | 刘通,林玮,冯萌,杨依,刘婷婷,张敏. 基于网络药理学分析小檗碱在免疫微环境中对糖尿病视网膜病变的作用及实验验证[J]. 山东大学耳鼻喉眼学报, 2023, 37(1): 94-104. |
[9] | 宋华荣,唐光华,朱任良. 面鼻眶脑毛霉病1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2022, 36(6): 96-100. |
[10] | 王茜,刘娜,王少鹏. Leber特发性星芒状视神经视网膜炎1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2022, 36(6): 106-110. |
[11] | 王旭,高芯,张玉光. 加速型角膜胶原交联术治疗真菌性角膜炎的临床研究[J]. 山东大学耳鼻喉眼学报, 2022, 36(5): 51-57. |
[12] | 王娇娇,李苗宋宗明. 糖尿病视网膜病变的机制和细胞模型研究进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(5): 93-99. |
[13] | 田俊, 刘良发, 白佳麒. 坏死性外耳道炎继发颈椎骨髓炎1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2022, 36(4): 1-5. |
[14] | 资昊坤,肖旭平,李云秋. 口服糖皮质激素在慢性鼻窦炎伴鼻息肉围手术期的应用现状[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 98-103. |
[15] | 陈世琴,卫平存,胡云龙,胡金旺. 糖皮质激素三种不同鼻用法对鼻内镜术后黏膜转归的影响[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 195-201. |
|