JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (1): 40-42.doi: 10.6040/j.issn.1673-3770.0.2015.310

Previous Articles     Next Articles

Expression and significance of ERK5 protein in nasal polyps cells.

GAO Zhenfeng1, TAO Qian2, CAI Xiaolan3   

  • Received:2015-07-28 Online:2016-02-16 Published:2016-02-16

PDF (PC)

439

Abstract: Objective To investigate the expression and significance of extracellular regulated protein kinases 5(ERK5)protein in nasal polyps cells. Methods The clinical data of patients with chronic rhinosinusitis in our hospital from January 2013 to December 2014 was analyzed, in which 37 patients with nasal polyps were treated as the observation group(CRSwNP group)and 35 patients without nasal polyps were treated as the control group(CRSsNP group). Results Serum TNF-α(t=16.7, P<16.7), IL-5 (t=13.81, P<0.001)and IL-8(t=8.642, P<0.001)levels of the patients in the CRSwNP group were significantly higher than those in the control group, the difference had statistical significance(P>0.05). The results of western boltting test found that ERK5 protein expression level in the CRSwNP group was significantly higher than in the control group(gamma ratio 1.21±0.16 vs 0.36±0.04, P<0.01, n=37). By using Pearson correlation test ERK5 protein expression of the CRSwNP group had significant positive correlation with TNF-α(r=0.521, P=0.001)and IL-8(r=0.479, P=0.479)level. Conclusion ERK5 protein in patients with nasal polyps show high expression level and positive correlation with TNF-α and IL-8 level.

Key words: Nasal polyp, Extracellular regulated protein kinases 5, ELISA

CLC Number: 

  • R765.2
[1] Miranda M, Rozali E, Khanna K K, et al. MEK5-ERK5 pathway associates with poor survival of breast cancer patients after systemic treatments[J]. Oncoscience, 2015, 2(2):99-101.
[2] Finegan K G, Perez-Madrigal D, Hitchin J R, et al. ERK5 is a critical mediator of inflammation-driven cancer[J]. Cancer Res, 2015, 75(4):742-753.
[3] 尹宏, 黄欣, 王海燕, 等. ERK5在胃腺癌组织中的表达及临床意义[J]. 中国现代医学杂志, 2014, 24(20):56-60. YIN Hong, HUANG Xin, WANG Haiyan, et al. Expression of ERK5 in gastric adenocarcinoma and its clinical significance[J]. Chin J Mod Med, 2014, 24(20):56-60.
[4] Yue B, Ren Q X, Su T, et al. ERK5 silencing inhibits invasion of human osteosarcoma cell via modulating the Slug/MMP-9 pathway[J]. Eur Rev Med Pharmacol Sci, 2014, 18(18):2640-2647.
[5] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科学组. 慢性鼻-鼻窦炎诊断和治疗指南(2012, 昆明)[J]. 中华耳鼻咽喉头颈外科杂志, 2013, 48(2):92-94.
[6] 王耀晟, 程晓曙, 洪葵, 等. 细胞外信号调节蛋白激酶5/凋亡调节蛋白信号途径在低温诱导心肌细胞损伤及凋亡中的调控作用[J]. 中国循环杂志, 2014(7):540-544. WANG Yaosheng, CHENG Xiaoshu, HONG Kui, et al. The regulative role of ERK5/Bim pathway in hypothermal stimulation induced neonatal rats cardiomyocytes injury and apoptosis[J]. Chin Circ J, 2014(7):540-544.
[7] Xiu Q, Meng C, Li L, et al. Allergic factors affect on severity of chronic rhinosinusitis and postoperative outcomes[J]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2015, 29(1):34-38, 44.
[8] Koseoglu S, Ozcan K M, Ikinciogullari A, et al. Evaluation of autoinflammatory disease genes in nasal polyposis[J]. Turk J Med Sci, 2015, 45(1):136-140.
[9] Wang C, Lou H, Wang X, et al. Effect of budesonide transnasal nebulization in patients with eosinophilic chronic rhinosinusitis with nasal polyps[J]. J Allergy Clin Immunol, 2015, 135(4):922-929.e6.
[10] Poposki J A, Peterson S, Welch K, et al. Elevated presence of myeloid dendritic cells in nasal polyps of patients with chronic rhinosinusitis[J]. Clin Exp Allergy, 2015, 45(2):384-393.
[11] Heo K S, Cushman H J, Akaike M, et al. ERK5 activation in macrophages promotes efferocytosis and inhibits atherosclerosis[J]. Circulation, 2014, 130(2):180-191.
[1] SONG Xiaoyu, ZHANG Yu, LI Chenglin, SONG Xicheng. Enhanced recovery after surgery for the treatment of chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(5): 9-12.
[2] HUANG Yuan, BA Luo, LI Bo, YU Wenxing, YANG Fangli, DU Jintao. Transcription factor NKX2-1 regulates eosinophilic inflammation in chronic rhinosinusitis with nasal polyps [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 17-23.
[3] CHEN Wangxing, ZHAO Xue, LIU Yan, LIU Yue, JIN Chunshun. Psychological status of patients with deviated nasal septum or chronic sinusitis with nasal polyps [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 24-27.
[4] Effect of short-term glucocorticoid inhalation on nasal symptoms and adrenocortical function in patients with eosinophilic chronic sinusitis accompanied by nasal polyps. Effect of short-term glucocorticoid inhalation on nasal symptoms and adrenocortical function in patients with eosinophilic chronic sinusitis accompanied by nasal polyps [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 28-31.
[5] LI Huabin, LAI Yuting. Pathogenesis, diagnosis, and treatment of chronic rhinosinusitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 4-9.
[6] YU Qianqian, GUAN Ge, ZHANG Niankai, LI Na, WEN Junfeng, LIU Tingting, LIAN Yuanyuan. Characteristics of respiratory epithelial adenomatoid hamartomas in the nasal olfactory cleft on computed tomography [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 76-81.
[7] LI Hongmei, WANG Lan, GAO Zhaohui, WANG Ying, XUE Jinmei. The expression and significance of p-ERK2/ ERK2 in nasal polyps [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 42-46.
[8] ZHANG Jie, GONG Qi. Clinical significance of eosinophils and neutrophils in blood and allergic reaction in patients with chronic rhinosinusitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 54-57.
[9] GAN Bin, ZHANG Yongju, XU Anting. BRF2 in the pathogenesis of chronic rhinosinusitis with nasal polyps [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 47-53.
[10] ZHI Lili, SONG Daoliang. Expressions of eosinophils and IL5 in antrochoanal polyps and nasal polyps. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 43-46.
[11] LUN Jie, ZHANG Ya′nan. Analysis on the factors related to the recurrence of chronic rhinosinusitis with nasal polyps. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 80-83.
[12] WANG Haipeng, XU Huijuan, ZHANG Xiufang, WANG Huizhong, LI Yanzhong. The application of Sinus Jel in adult patients of nasal polyps with sleep-disordered breathing. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(5): 58-60.
[13] SU Yi, XIE Jinghua, PAN Xiaoli, ZENG Guoqing. Efficacy and associated factors of endoscopic sinus surgery on patients with chronic rhinosinusitis with or without nasal polyps. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(4): 86-89.
[14] LI Houjie, QU Qian, XU Shicai, LIU Lingbing, ZHANG Yongchao, WANG Xuzeng, LIU Lei. Clinical experience on the treatment of antrochoanal polyp under nasal endoscopy by expand road of the combined middle-inferior meatus. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(2): 62-64.
[15] ZHANG Jian, LU Xiaoqing, WU Jian.. Differentially expressed proteins between nasal polyps and normal nasal mucosa by the iTRAQ technology. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(1): 5-8.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd