JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (1): 40-42.doi: 10.6040/j.issn.1673-3770.0.2015.310

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Expression and significance of ERK5 protein in nasal polyps cells.

GAO Zhenfeng1, TAO Qian2, CAI Xiaolan3   

  • Received:2015-07-28 Online:2016-02-16 Published:2016-02-16

Abstract: Objective To investigate the expression and significance of extracellular regulated protein kinases 5(ERK5)protein in nasal polyps cells. Methods The clinical data of patients with chronic rhinosinusitis in our hospital from January 2013 to December 2014 was analyzed, in which 37 patients with nasal polyps were treated as the observation group(CRSwNP group)and 35 patients without nasal polyps were treated as the control group(CRSsNP group). Results Serum TNF-α(t=16.7, P<16.7), IL-5 (t=13.81, P<0.001)and IL-8(t=8.642, P<0.001)levels of the patients in the CRSwNP group were significantly higher than those in the control group, the difference had statistical significance(P>0.05). The results of western boltting test found that ERK5 protein expression level in the CRSwNP group was significantly higher than in the control group(gamma ratio 1.21±0.16 vs 0.36±0.04, P<0.01, n=37). By using Pearson correlation test ERK5 protein expression of the CRSwNP group had significant positive correlation with TNF-α(r=0.521, P=0.001)and IL-8(r=0.479, P=0.479)level. Conclusion ERK5 protein in patients with nasal polyps show high expression level and positive correlation with TNF-α and IL-8 level.

Key words: Nasal polyp, Extracellular regulated protein kinases 5, ELISA

CLC Number: 

  • R765.2
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