Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (6): 118-122.doi: 10.6040/j.issn.1673-3770.0.2019.582

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Elucidating the role and mechanism of Tim-3 in allergic rhinitis

XIANG Liulan1, YE Yuanhang1Overview,JIANG Luyun2, LIU Yang2Guidance   

  1. 1. Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan, China;
    2. Department of Otorhinolaryngology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan,  China
  • Published:2021-01-11

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Abstract: Allergic rhinitis(AR)is a chronic, non-specific inflammatory disease of the nasal mucosa. As a Type I hypersensitivity reaction, it leads to several diseases and labor losses and is a global health problem that burdens society. Different proteins, including Tim-3, regulate the immune cells that are involved in the pathogenesis of AR. Tim-3 has been demonstrated to be involved in immune cell expression and has a regulatory effect on several immune responses. Thus, it is also closely related to disorders of the immune system. Presently, the treatment options and medications for AR are limited, and it require more effective therapeutic interventions. While there are several studies on Tim-3's mechanism of action in AR, a review of the available literature is lacking. This article aims to enrich the body of research on the immune regulation mechanism behind AR and provide new ideas for its treatment.

Key words: Allergic rhinitis, T cell immunoglobulin domain and mucin domain protein-3, Pathogenesis, Review

CLC Number: 

  • R765
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