Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (1): 86-91.doi: 10.6040/j.issn.1673-3770.0.2020.157

Previous Articles     Next Articles

Relationship between serum procalcitonin level of tumor-bearing mice and medullary thyroid carcinoma

ZENG Bo, TIAN Xingde   

  1. Department of Otolaryngology & Head and Neck Surgery, the First Affiliated Hospital of Yangtze University, Jingzhou 434000, Hubei,  China
  • Published:2021-02-01

PDF (PC)

165

Abstract: Objective To study the relationship between serum procalcitonin(PCT)and calcitonin(CT)levels in medullary thyroid carcinoma(MTC). Methods We evaluated the serum PCT and CT levels, tumor weight and volume, and bodyweight using MTC mice models to ascertain the relationship between serum PCT and CT and tumors. Results Serum PCT and CT in the group A mice were significantly and positively correlated with tumor weight; serum PCT and CT were also positively correlated. Conclusions This experiment demonstrates that serum PCT may be used as a tumor marker for MTC, in addition to serum CT, which has demonstrated utility for the diagnosis of MTC.

Key words: Medullary thyroid carcinoma, Procalcitonin, Calcitonin, Serum, Level, Mice

CLC Number: 

  • R762
[1] 陈晓红. 遗传型甲状腺髓样癌的精准化治疗[J]. 山东大学耳鼻喉眼学报, 2016, 30(2): 23-27. doi: 10.6040/j.issn.1673-3770.1.2016.07. CHEN Xiaohong. Precision therapy on medullary thyroid carcinoma[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2016, 30(2): 23-27. doi: 10.6040/j.issn.1673-3770.1.2016.07.
[2] Hadoux J, Pacini F, Tuttle RM, et al. Management of advanced medullary thyroid cancer[J]. Lancet Diabetes Endo, 2016, 4(1): 64-71. doi: 10.1016/S2213-8587(15)00337-X.
[3] 潘新良. 加强甲状腺结节及恶性肿瘤的规范治疗[J]. 山东大学耳鼻喉眼学报, 2020, 34(3): 1-11. doi: 10.6040/j.issn.1673-3770.1.2020.037. PAN Xinliang. Improving the standard treatments for thyroid nodules and malignant tumors[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(3): 1-11. doi: 10.6040/j.issn.1673-3770.1.2020.037.
[4] 龚艳萍, 刘枫, 邹秀和, 等. 甲状腺髓样癌的诊治进展[J]. 中国普外基础与临床杂志, 2016, 23(5): 620-625. doi: 10.7507/1007-9424.20160168. GONG Yanping, LIU Feng, ZOU Xiuhe, et al. Progression of diagnosis and treatment of medullary thyroid carcinoma[J]. Chin J Bases Clin General Surg, 2016, 23(5): 620-625. doi: 10.7507/1007-9424.20160168.
[5] Allelein S, Ehlers M, Morneau C, et al. Measurement of basal serum calcitonin for the diagnosis of medullary thyroid cancer[J]. Horm Et Metab, 2018, 50(1): 23-28. doi:10.1055/s-0043-122237.
[6] 陈伟才. 降钙素和癌胚抗原联合检测应用于甲状腺髓样癌诊治的价值[J]. 深圳中西医结合杂志, 2018, 28(7): 19-21. doi: 10.16458/j.cnki.1007-0893.2018.07.008.
[7] Samà MT, Rossetto Giaccherino R, Gallo M, et al. Clinical challenges with calcitonin-negative medullary thyroid carcinoma[J]. J Cancer Res Clin Oncol, 2016, 142(9): 2023-2029. doi:10.1007/s00432-016-2169-5.
[8] Ittner L, Born W, Rau B, et al. Circulating procalcitonin and cleavage products in septicaemia compared with medullary thyroid carcinoma[J]. European Journal of Endocrinology, 2002, 147(6): 727-731. doi: 10.1530/eje.0.1470727,
[9] 李逢将, 王凤, 苑鑫, 等. 通过降钙素原异常升高发现甲状腺髓样癌一例[J]. 中华肺部疾病杂志(电子版), 2017, 10(4): 495-496. doi: 10.3877/cma.j.issn.1674-6902.2017.04.033
[10] d'Herbomez M, Caron P, Bauters C, et al. Reference range of serum calcitonin levels in humans: influence of calcitonin assays, sex, age, and cigarette smoking[J]. Eur J Endocrinol, 2007, 157(6): 749-755. doi:10.1530/EJE-07-0566.
[11] Saltiki K, Rentziou G, Stamatelopoulos K, et al. Small medullary thyroid carcinoma: post-operative calcitonin rather than tumour size predicts disease persistence and progression[J]. Eur J Endocrinol, 2014, 171(1): 117-126. doi:10.1530/EJE-14-0076.
[12] Wells SA Jr, Asa SL, Dralle H, et al. Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma[J]. Thyroid, 2015, 25(6): 567-610. doi:10.1089/thy.2014.0335.
[13] Machens A, Dralle H. Biomarker-based risk stratification for previously untreated medullary thyroid cancer[J]. J Clin Endocrinol Metab, 2010, 95(6): 2655-2663. doi:10.1210/jc.2009-2368.
[14] 徐书杭, 李春睿, 刘超. 儿童甲状腺癌的规范化诊治[J]. 山东大学耳鼻喉眼学报, 2017, 31(6): 12-15. doi: 10.6040/j.issn.1673-3770.1.2017.038. XU Shuhang, LI Chunrui, LIU Chao. Optimal management of differentiated thyroid carcinoma in children[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2017, 31(6): 12-15. doi: 10.6040/j.issn.1673-3770.1.2017.038.
[15] 季娟娟, 孙耕耘. 降钙素原和常用炎症指标在脓毒症诊断及预后中的价值[J]. 中华肺部疾病杂志(电子版), 2015, 8(4): 416-420. doi: 10.3877/cma.j.issn.1674-6902.2015.04.002. JI Juanjuan, SUN Gengyun. The diagnostic value and prognostic significance of serum procalcitonin and Common inflammatory markers in patients with sepsis[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2015, 8(4): 416-420. doi: 10.3877/cma.j.issn.1674-6902.2015.04.002.
[16] 高占成. 降钙素原对诊断慢性阻塞性肺疾病急性加重的应用价值[J]. 中华结核和呼吸杂志, 2013, 36(4): 313-314. doi: 10.3760/cma.j.issn.1001-0939.2013.04.025.
[17] 张立, 徐婷, 林勇. 降钙素原指导抗生素治疗策略在社区获得性下呼吸道感染中应用的荟萃分析[J]. 中华结核和呼吸杂志, 2012, 35(4): 275-282. doi: 10.3760/cma.j.issn.1001-0939.2012.04.012. ZHANG Li, XU Ting, LIN Yong. Procalcitonin-guided algorithms of antibiotic therapy in community-acquired lower respiratory tractinfections: a systematic review and meta-analysis of randomized controlled trials[J]. Chinese Journal of Tuberculosis and Respiratory Diseases, 2012, 35(4): 275-282. doi: 10.3760/cma.j.issn.1001-0939.2012.04.012.
[18] Bihan H, Becker KL, Snider RH, et al. Calcitonin precursor levels in human medullary thyroid carcinoma[J]. Thyroid, 2003, 13(8): 819-822. doi:10.1089/105072503768499716.
[19] Bolko P, Manuszewska-Jopek E, Michaek K, et al. Efficacy of procalcitonin measurement in patients after total thyroidectomy due to medullary thyroid carcinoma[J]. Arch Immunol Ther Exp(Warsz), 2003, 51(6): 415-419.
[20] 赵岚, 崔天盆, 张家衡, 等. 甲状腺髓样癌血清降钙素原异常增高[J]. 中华检验医学杂志, 2015, 38(4): 283-284. doi: 10.3760/cma.j.issn.1009-9158.2015.04.017.
[21] Giovanella L, Imperiali M, Piccardo A, et al. Procalcitonin measurement to screen medullary thyroid carcinoma: a prospective evaluation in a series of 2705 patients with thyroid nodules[J]. Eur J Clin Invest, 2018, 48(6): e12934. doi:10.1111/eci.12934.
[22] 胡欣, 韩雪, 陈国芳, 等. 血清降钙素原在甲状腺髓样癌诊断及随访中的临床价值[J]. 临床内科杂志, 2020, 37(1): 69-70. doi: 10.3969/j.issn.1001-9057.2020.01.023.
[23] Woliński K, Kaznowski J, Klimowicz A, et al. Diagnostic value of selected biochemical markers in the detection of recurrence of medullary thyroid cancer - comparison of calcitonin, procalcitonin, chromogranin A, and carcinoembryonic antigen[J]. Endokrynol Pol, 2017, 68(4): 434-437. doi:10.5603/EP.a2017.0038.
[24] Trimboli P, Seregni E, Treglia G, et al. Procalcitonin for detecting medullary thyroid carcinoma: a systematic review[J]. Endocr Relat Cancer, 2015, 22(3): R157-R164. doi:10.1530/ERC-15-0156.
[25] Brutsaert EF, Gersten AJ, Tassler AB, et al. Medullary thyroid cancer with undetectable serum calcitonin[J]. J Clin Endocrinol Metab, 2015, 100(2): 337-341. doi:10.1210/jc.2014-3095.
[26] Giovanella L, Verburg FA, Imperiali M, et al. Comparison of serum calcitonin and procalcitonin in detecting medullary thyroid carcinoma among patients with thyroid nodules[J]. Clin Chem Lab Med, 2013, 51(7): 1477-1481. doi:10.1515/cclm-2012-0610.
[1] FU Yihao, XU Yixuan,YAN Hong, ZHANG Jie. Recent research advances in the role of glutaredoxin in oculopathy [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(3): 125-130.
[2] LI Jianzhong, ZHOU Yongrui, LI Huiying, LI Miaobian, SUN Yidi, QIU Qianhui. A study of low-temperature plasma ablation for the treatment of benign thyroid nodules under ultrasound guidance [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(2): 34-38.
[3] Lu LUO,En ZHOU,Si OUYANG,Yi CHEN,Xuping XIAO,Jihua WANG. Expression of the microRNA let-7a in the serum of 42 patients with laryngeal cancer and its significance [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 96-100.
[4] PU Hongbo, DU Xiaodong. Allergen test results in 2 000 patients with allergic rhinitis in Wuxi District [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 105-107.
[5] REN Tao, TANG Yijun, WANG Meifang, LIU Yan, QIAN Xin.. Effect of obstructive sleep apnea-hypopnea syndrome on blood glucose, serum lipid, and C-reactive protein levels. [J]. J Otolaryngol Ophthalmol Shandong Univ, 2017, 31(6): 53-57.
[6] . Evaluation of hearing levels, speech functions and cognitive abilities of cochlear implantation in deaf children with abnormal white matter. [J]. J Otolaryngol Ophthalmol Shandong Univ, 2017, 31(2): 43-48.
[7] . Serum lipid changes in obstructive sleep apnea hypopnea syndrome patients underwent airway surgery. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(1): 27-30.
[8] . Clinical efficacy of Tiebifu Granule in the treatment of deafness with iron deficiency. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(1): 75-79.
[9] JIN Chengxun, ZHAO Xue, LIU Yue, WEI Ning, JIN Chunshun. Report of 11 cases of Kimuras disease and review of literature. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(6): 63-66.
[10] TAI Xuhui, YANG Xin, ZHU Baoyu, CAO Hong, CHU Yanling, SHAN Xiaodong, JIANG Yu. Analysis of allergen spectrum in 2 883 patients with allergic rhinitis in Liaoning area. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(4): 39-42.
[11] YU Pengju, XU Fenglei, YANG Jun, CHEN Wei, JIANG Manjie. Diagnostic value of plasma 1-3-β-D glucan for fungal rhinosinusitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(4): 94-97.
[12] CHEN Xiaohong. Precision therapy on medullary thyroid carcinoma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(2): 23-27.
[13] HENG Weiwei, HOU Jie, WEI Xianmei, SHE Wandong. Expressions and significance of TNF-α and IL-8 in serum and peripheral blood mononuclear cells from patients with sudden sensorineural hearing loss. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(2): 40-45.
[14] LIN Li, YANG Xu. Analysis on efficacy of treatment of corneal epithelial dysfunction after cataract surgery. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(2): 84-86.
[15] ZOU Juanjuan, WANG Yan, LI Yanzhong. Changes of serum myocardial enzymes and uric acid in patients with severe obstructive sleep apnea hypopnea syndrome complicated with hypertension [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(5): 1-5.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] YANG Changliang,HUANG Zhiwu,YAO Hangqi,ZHU Yong,SNU Yi . Study on auditory brainstem response[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 9 -13 .
[2] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 89 -89 .
[3] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 90 -91 .
[4] LIU Da-yu,PAN Xin-liang,LEI Da-peng,ZHANG Li-qiang,LUAN Xin-yong . Surgical treatment for medial wall pyriform sinus cancer[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2007, 21(1): 8 -11 .
[5] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(2): 188 -188 .
[6] LIU Yan,LIU Xin-yi,WANG Jin-ping,LI Da-jian . Measurement of the posterior tympanum and its clinical significance [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 218 -221 .
[7] ZHAO Min,WANG Shou-sen,ZHEN Ze-nian,CHEN Xian-ming,WANG Mao-xin . Sphenoid sinus and trans-sphenoid surgery under nasal endoscopy and microscopy [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 244 -245 .
[8] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 252 -252 .
[9] WANG Hong-xia,WANG Peng-cheng . Expression of NSE,S100 and GFAP in retinoblastoma and its clinical significance[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 263 -264 .
[10] HUANG Fang,HUANG Hai-qiong,HUANG Jian-qiang,HE He-fan . Bronchoscopic video supervision system in infant bronchial foreign bodies[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 276 -277 .
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd