Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (3): 50-55.doi: 10.6040/j.issn.1673-3770.0.2021.533

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Eosinophils and Olfactory Dysfunction

YI RuonanOverview,CHEN Fuquan   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi'an 710032, Shaanxi, China
  • Published:2022-06-15

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Abstract: Chronic rhinosinusitis(CRS)is a refractory disease with a very complex pathogenesis. Olfactory dysfunction is an important clinical symptoms of CRS.Despite drug and surgical intervention, the recurrence rate of CRS is high, and the olfactory dysfunction of patients sometimes cannot be improved, which may seriously affects a patient's quality of life.Eosinophils(EOS)are an important cell type.The degradation and accumulation of eosinophils, the release of cytokines and mucus secretion play important roles in the pathogenesis of different types of chronic rhinosinusitis. While many scholars consider that tissue EOS to be closely related to olfactory dysfunction caused by peripheral blood EOS and CRS, but some scholars hold different views.

Key words: Eosinophils, Olfactory dysfunction, Chronic rhinosinusitis, Olfactory Mucosa

CLC Number: 

  • R765.4
[1] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科学组. 嗅觉障碍诊断和治疗专家共识(2017年)[J]. 中华耳鼻咽喉头颈外科杂志, 2018(7): 484-494. doi:10.3760/cma.j.issn.1673-0860.2018.07.002.
[2] 王士美, 王义杰. 慢性鼻-鼻窦炎及鼻息肉伴嗅觉障碍患者鼻内镜术后嗅觉变化分析[J]. 中国实用医药, 2015, 10(27): 15-16. doi:10.14163/j.cnki.11-5547/r.2015.27.007. WANG Shimei, WANG Yijie. Analysis of olfaction changes after nasal endoscopic surgery for chronic rhinosinusitis and nasal polyp;complicated with dysosmia patients[J]. China Practical Medicine, 2015, 10(27): 15-16. doi:10.14163/j.cnki.11-5547/r.2015.27.007.
[3] 陈艳娣, 孙焕然, 孟粹达, 等. 伴嗅觉障碍的慢性鼻-鼻窦炎患者术后嗅觉变化的临床研究[J]. 国际耳鼻咽喉头颈外科杂志, 2020, 44(2): 75-78. doi:10.3760/cma.j.issn.1673-4106.2020.02.008. CHEN Yandi, SUN Huanran, MENG Cuida, et al. Clinical studies on postoperative olfactory changes in chronic sinusitis patients with olfactory dysfunction[J]. International Journal of Otolaryngology-Head and Neck Surgery, 2020, 44(2): 75-78. doi:10.3760/cma.j.issn.1673-4106.2020.02.008.
[4] Mullol J, Mariño-Sánchez F, Valls M, et al. The sense of smell in chronic rhinosinusitis[J]. J Allergy Clin Immunol, 2020, 145(3): 773-776. doi:10.1016/j.jaci.2020.01.024.
[5] Castillo M. The complicated equation of smell, flavor, and taste[J]. AJNR Am J Neuroradiol, 2014, 35(7): 1243-1245. doi:10.3174/ajnr.A3739.
[6] 姜彦, 张增潇. 嗅觉功能障碍诊治研究进展[J]. 中国中西医结合耳鼻咽喉科杂志, 2020, 28(3): 165-169. doi:10.16542/j.cnki.issn.1007-4856.2020.03.002. JIANG Yan, ZHANG Zengxiao. The diagnosis and treatment of olfactory dysfunction[J]. Chinese Journal of Otorhinolaryngology in Integrative Medicine, 2020, 28(3): 165-169. doi:10.16542/j.cnki.issn.1007-4856.2020.03.002.
[7] Hummel T, Whitcroft KL, Andrews P, et al. Position paper on olfactory dysfunction[J]. Rhinol Suppl, 2017, 54(26): 1-30. doi:10.4193/Rhino16.248.
[8] Wu DW, Bleier BS, Wei YX. Temporary olfactory improvement in chronic rhinosinusitis with nasal polyps after treatment[J]. Eur Arch Otorhinolaryngol, 2018, 275(9): 2193-2202. doi:10.1007/s00405-018-5066-5.
[9] Mullol J, Mariño-Sánchez F, Valls M, et al. The sense of smell in chronic rhinosinusitis[J]. J Allergy Clin Immunol, 2020, 145(3): 773-776. doi:10.1016/j.jaci.2020.01.024.
[10] Yan XG, Whitcroft KL, Hummel T. Olfaction: Sensitive indicator of inflammatory burden in chronic rhinosinusitis[J]. Laryngoscope Investig Otolaryngol, 2020, 5(6): 992-1002. doi:10.1002/lio2.485.
[11] Besser G, Liu DT, Renner B, et al. Reversible obstruction of the olfactory cleft: impact on olfactory perception and nasal patency[J]. Int Forum Allergy Rhinol, 2020, 10(6): 713-718. doi:10.1002/alr.22549.
[12] Kashiwagi T, Tsunemi Y, Akutsu M, et al. Postoperative evaluation of olfactory dysfunction in eosinophilic chronic rhinosinusitis-comparison of histopathological and clinical findings[J]. Acta Otolaryngol, 2019, 139(10): 881-889. doi:10.1080/00016489.2019.1654131.
[13] Ahn SH, Lee EJ, Ha JG, et al. Comparison of olfactory and taste functions between eosinophilic and non-eosinophilic chronic rhinosinusitis[J]. Auris Nasus Larynx, 2020, 47(5): 820-827. doi:10.1016/j.anl.2020.04.006.
[14] Takahashi K, Sadamatsu H, Suzuki K, et al. Evaluation of olfactory dysfunction to estimate the presence of eosinophilic chronic rhinosinusitis in patients with asthma[J]. Respir Investig, 2021, 59(1): 126-134. doi:10.1016/j.resinv.2020.08.004.
[15] 赵松花, 孙绍辉, 陈娜, 等. 嗜酸细胞性慢性鼻-鼻窦炎嗅觉障碍与嗜酸性粒细胞的关系[J]. 武警医学, 2015, 26(4): 350-352. doi:10.14010/j.cnki.wjyx.2015.04.008. ZHAO Songhua, SUN Shaohui, CHEN Na, et al. Relationship between olfactory dysfunction and eosinophil counts in eosinophilic chronic sinusitis[J]. Medical Journal of the Chinese People's Armed Police Forces, 2015, 26(4): 350-352. doi:10.14010/j.cnki.wjyx.2015.04.008.
[16] Bachert C, Marple B, Schlosser RJ, et al. Adult chronic rhinosinusitis[J]. Nat Rev Dis Primers, 2020, 6(1): 86. doi:10.1038/s41572-020-00218-1.
[17] Azizzadeh Delshad A, Jalali Nadoushan M, Davati A, et al. Expression of vascular endothelial growth factor in nasal polyp and chronic rhinosinusitis[J]. Iran J Pathol, 2016, 11(3): 231-237.
[18] Burnham ME, Esnault S, Roti Roti EC, et al. Cholesterol selectively regulates IL-5 induced mitogen activated protein kinase signaling in human eosinophils[J]. PLoS One, 2014, 9(8): e103122. doi:10.1371/journal.pone.0103122.
[19] van Zele T, Holtappels G, Gevaert P, et al. Differences in initial immunoprofiles between recurrent and nonrecurrent chronic rhinosinusitis with nasal polyps[J]. Am J Rhinol Allergy, 2014, 28(3): 192-198. doi:10.2500/ajra.2014.28.4033.
[20] Kim DK, Choi SA, Eun KM, et al. Tumour necrosis factor alpha and interleukin-5 inhibit olfactory regeneration via apoptosis of olfactory sphere cells in mice models of allergic rhinitis[J]. Clin Exp Allergy, 2019, 49(8): 1139-1149. doi:10.1111/cea.13401.
[21] Lou HF, Zhang N, Bachert C, et al. Highlights of eosinophilic chronic rhinosinusitis with nasal polyps in definition, prognosis, and advancement[J]. Int Forum Allergy Rhinol, 2018, 8(11): 1218-1225. doi:10.1002/alr.22214.
[22] Hauser LJ, Chandra RK, Li P, et al. Role of tissue eosinophils in chronic rhinosinusitis-associated olfactory loss[J]. Int Forum Allergy Rhinol, 2017, 7(10): 957-962. doi:10.1002/alr.21994.
[23] Morse JC, Shilts MH, Ely KA, et al. Patterns of olfactory dysfunction in chronic rhinosinusitis identified by hierarchical cluster analysis and machine learning algorithms[J]. Int Forum Allergy Rhinol, 2019, 9(3): 255-264. doi:10.1002/alr.22249.
[24] Zhang LC, Hu CH, Sun ZF, et al. Correlation of tissue eosinophil count and chemosensory functions in patients with chronic rhinosinusitis with nasal polyps after endoscopic sinus surgery[J]. Eur Arch Otorhinolaryngol, 2019, 276(7): 1987-1994. doi:10.1007/s00405-019-05413-9.
[25] 陶丹丹, 董红军, 褚云锋, 等. 慢性鼻-鼻窦炎伴鼻息肉患者组织嗜酸性粒细胞与嗅觉功能障碍的相关性研究[J]. 山东大学耳鼻喉眼学报, 2020, 34(6): 16-20. doi:10.6040/j.issn.1673-3770.0.2019.388. TAO Dandan, DONG Hongjun, CHU Yunfeng, et al. Correlation between eosinophils and olfactory dysfunction in patients with CRSwNP after nasal operation[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(6): 16-20. doi:10.6040/j.issn.1673-3770.0.2019.388.
[26] Farrell NF, Mace JC, Sauer DA, et al. Mucosal eosinophilia and neutrophilia are not associated with QOL or olfactory function in chronic rhinosinusitis[J]. Am J Rhinol Allergy, 2021, 35(5): 647-655. doi:10.1177/1945892420987439.
[27] Chowdhury NI, Chandra RK, Li P, et al. Investigating the correlation between mucus cytokine levels, inflammatory cell counts, and baseline quality-of-life measures in chronic rhinosinusitis[J]. Int Forum Allergy Rhinol, 2019, 9(5): 538-544. doi:10.1002/alr.22287.
[28] Succar EF, Li P, Ely KA, et al. Neutrophils are underrecognized contributors to inflammatory burden and quality of life in chronic rhinosinusitis[J]. Allergy, 2020, 75(3):713-716. doi: 10.1111/all.14071.
[29] Soler ZM, Sauer D, Mace J, et al. Impact of mucosal eosinophilia and nasal polyposis on quality-of-life outcomes after sinus surgery[J]. Otolaryngol Head Neck Surg, 2010, 142(1): 64-71. doi:10.1016/j.otohns.2009.10.005.
[30] El Rassi E, Mace JC, Steele TO, et al. Sensitivity analysis and diagnostic accuracy of the Brief Smell Identification Test in patients with chronic rhinosinusitis[J]. Int Forum Allergy Rhinol, 2016, 6(3): 287-292. doi:10.1002/alr.21670.
[31] Pan XD, Zhang Y, Wang CS, et al. Evaluation of nasal symptoms to distinguish eosinophilic from noneosinophilic nasal polyps based on peripheral blood[J]. Allergy Asthma Proc, 2021, 42(3): 214-221. doi:10.2500/aap.2021.42.210004.
[32] Tay TR, Hew M. Comorbid “treatable traits” in difficult asthma: current evidence and clinical evaluation[J]. Allergy, 2018, 73(7): 1369-1382. doi:10.1111/all.13370.
[33] Shah SA, Ishinaga H, Takeuchi K. Pathogenesis of eosinophilic chronic rhinosinusitis[J]. J Inflamm(Lond), 2016, 13: 11. doi:10.1186/s12950-016-0121-8.
[34] Wu DW, Li Y, Bleier BS, et al. Superior turbinate eosinophilia predicts olfactory decline in patients with chronic rhinosinusitis[J]. Ann Allergy Asthma Immunol, 2020, 125(3): 304-310.e1. doi:10.1016/j.anai.2020.04.027.
[35] Sehanobish E, Barbi M, Fong V, et al. COVID-19-induced anosmia and ageusia are associated with younger age and lower blood eosinophil counts[J]. Am J Rhinol Allergy, 2021, 35(6): 830-839. doi:10.1177/19458924211004800.
[36] 崔哲洙, 严永峰, 崔春莲, 等. 嗜酸性粒细胞在变应性鼻炎合并慢性鼻窦炎的分布特点[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 250-252.
[37] 王立英, 刘强, 曹震. 外周血嗜酸性粒细胞与慢性鼻-鼻窦炎并鼻息肉患者嗅觉障碍的关系[J]. 广东医学, 2021, 42(4): 494-496. doi:10.13820/j.cnki.gdyx.20192936.
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