舌下免疫治疗变应性鼻炎的疗效分析

doi:10.6040/j.issn.1673-3770.0.2015.360

摘要/Abstract

摘要： 目的评价标准化粉尘螨滴剂舌下免疫治疗(SLIT)中-重度持续性变应性鼻炎(AR)患者的临床效果。方法选择62例中-重度持续性AR患者,采用为期2年的SLIT治疗方案。所有患者变应原皮肤点刺试验粉尘螨和(或)屋尘螨皮肤指数≥3+。治疗前后对患者鼻部症状和小气道功能分别应用视觉模拟量表(VAS)和最大用力呼气流速-容量曲线(MEFV)进行评分测定,比较患者治疗前后鼻部症状和小气道功能的变化。结果 SLIT治疗后AR患者喷嚏、流涕、鼻塞、鼻痒的VAS评分较治疗前均明显下降(P<0.01)。SLIT治疗后AR患者MEFV测定结果中最大呼气中期流量(MMEF),用力呼气25%、50%肺活量的瞬间流速(FEF25%、FEF50%)均较治疗前明显改善(P<0.01)。结论 SLIT治疗中-重度持续性AR效果良好。

关键词: 免疫治疗, 变应性鼻炎, 小气道功能, 粉尘螨滴剂

Abstract: Objective To investigate the clinical efficacy of sublingual immunotherapy(SLIT)of standardized dermatophagoides farinae drops in patients with allergic rhinitis. Methods Totally 62 patients with moderate to severe persistent allergic rhinitis caused by dust mite received SLIT for two years. Dust mites and(or)house dust mite allergen skin prick index of all patients was ≥3+. Visual analog scale(visual analogue scale, VAS)and the maximum forced expiratory flow-volume curve(maximal expiratory flow-volume curve, MEFV)score were respectively applied to determine the nasal symptoms and small airway function before and after treatment. Results SLIT significantly reduced the individual symptoms like sneezing, rhinorrhea, nasal obstruction and pruritus after two years treatment when compared with the baseline, and the VAS scores of each symptom decreased significantly(P<0.01). The results of MEFV showed that MMEF, FEF25% and FEF50% were significantly improved after two years of SLIT treatment with significant differences(P<0.01). Conclusion SLIT of standardized dermatophagoides farinae drops has an favorite effect in patients with moderate to severe persistent allergic rhinitis.

Key words: Small airway function, Sublingual immunotherapy, Allergic rhinitis, Dermatophagoides farinae drops

中图分类号:

R765.21

顾晓,陈彦林. 舌下免疫治疗变应性鼻炎的疗效分析[J]. 山东大学耳鼻喉眼学报, 2016, 30(1): 17-20.

GU Xiao, CHEN Yanlin.. Clinical efficacy of sublingual immunotherapy in patients with allergic rhinitis.[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(1): 17-20.

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