山东大学耳鼻喉眼学报 ›› 2017, Vol. 31 ›› Issue (1): 103-106.doi: 10.6040/j.issn.1673-3770.0.2016.201

• 无栏目 • 上一篇    下一篇

各型青光眼患者眼内TNF-α及IP-10水平及其相关性分析

童尧1,郑岩1,2,周雅丽1,王艺晓1,赵培泉1,汪朝阳1   

  1. 1.上海交通大学医学院附属新华医院眼科, 上海 200092;
    2.上海交通大学医学院附属新华医院崇明分院眼科, 上海 202150
  • 收稿日期:2016-05-06 出版日期:2017-02-16 发布日期:2017-02-16
  • 通讯作者: 汪朝阳. E-mail:zhaokekewzy@hotmail.com
  • 基金资助:
    国家自然科学基金面上项目(81371040);上海市浦江人才计划(15PJD028)

The aqueous levels of TNF-α and IP-10 in different kinds of glaucoma and their correlation.

  1. Department of Ophthalmology, 1. Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China;2. Xinhua Hospital Chongming Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, 202150, China
  • Received:2016-05-06 Online:2017-02-16 Published:2017-02-16

PDF (PC)

378

摘要： 目的 探讨各型青光眼患者房水中肿瘤坏死因子-α( TNF-α)和趋化因子-10(IP-10)水平及两种因子之间的相关性。 方法 选取青光眼患者27例为青光眼组,另选取眼压正常的白内障患者28例为对照组,采集房水,用流式微球芯片分析技术进行检测,并对数据进行统计分析。 结果 青光眼患者眼内TNF-α(2.57±0.82)pg/mL及IP-10(990.15±766.84)pg/mL的水平显著高于对照组(P=0.003)。其中,原发性急性闭角型青光眼(AACG)组眼内TNF-α水平显著高于慢性闭角型青光眼(CACG)组;AACG组患者眼内IP-10水平高于CACG组与对照组。此外,青光眼患者眼内IP-10的水平与TNF-α的水平呈正相关(r=0.841, P<0.001)。 结论 TNF-α及IP-10可能参与青光眼的发生与发展,不同发病机制可能导致不同的炎症反应水平,此外,IP-10的水平与TNF-α的水平呈正相关。

关键词: 细胞因子, 肿瘤坏死因子-α, 青光眼, 趋化因子-10

Abstract: Objective To investigate the aqueous levels of tumor necrosis factor-α( TNF-α)and interferon-inducible protein-10( IP-10)in glaucoma and the correlation of them. Methods A total of 27 glaucoma patients were recruited and set as the glaucoma group, and another 28 cataract patients with normal intraocular pressure were also selected as the control group. Aqueous fluid of those patients were collected, and the detection of the concentrations of TNF-αand IP-10 was carried out using the cytometric bead array. The outcomes were further analyzed by SPSS 13.0. Results The mean concentrations of TNF-α and IP-10 in eyes with glaucoma were 2.57±0.82 pg/mL and 990.15±766.84 pg/mL respectively, significantly higher than those of eyes with cataract(P=0.003). In subgroup analysis, the concentration of TNF-α in eyes with acute angle closure glaucoma(AACG)was higher than eyes with chronic angle closure glaucoma(CACG); The concentration of IP-10 in the AACG group was higher than that in the CACG and the control group. Besides, the level of IP-10 was positively correlated with the level of TNF-α(r=0.841, P<0.001). Conclusion TNF-α and IP-10 may play important role in the pathogenesis of glaucoma, and different pathogenesis may lead to different level of inflammatory response. The level of IP-10 was positively correlated with TNF-α.

Key words: Glaucoma, Cytokines, Tumor necrosis factor-α, Interferon-inducible protein-10

中图分类号: 

  • R775.3
[1] Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020[J]. Br J Ophthalmol, 2006, 90(3):262-267.
[2] Sommer A. Intraocular pressure and glaucoma[J]. Am J Ophthalmol, 1989, 107(2):186-188.
[3] Tezel G, Wax MB. The immune system and glaucoma[J]. Curr Opin Ophthalmol, 2004, 15(2):80-84.
[4] Li G, Luna C, Liton PB, et al. Sustained stress response after oxidative stress in trabecular meshwork cells[J]. Mol Vis, 2007, 13:2282-2288.
[5] Nakabayashi M. Review of the ischemia hypothesis for ocular hypertension other than congenital glaucoma and closed-angle glaucoma[J]. Ophthalmologica, 2004, 218(5):344-349.
[6] Helbig H, Schlotzer-Schrehardt U, Noske W, et al. Anterior-chamber hypoxia and iris vasculopathy in pseudoexfoliation syndrome[J]. Ger J Ophthalmol, 1994, 3(3):148-153.
[7] Yu AL, Fuchshofer R, Kampik A, et al. Effects of oxidative stress in trabecular meshwork cells are reduced by prostaglandin analogues[J]. Invest Ophthalmol Vis Sci, 2008, 49(11):4872-4880.
[8] Chua J, Vania M, Cheung CM, et al. Expression profile of inflammatory cytokines in aqueous from glaucomatous eyes[J]. Mol Vis, 2012, 18:431-438.
[9] Borkenstein A, Faschinger C, Maier R, et al. Measurement of tumor necrosis factor-alpha, interleukin-6, Fas ligand, interleukin-1α, and interleukin-1β in the aqueous humor of patients with open angle glaucoma using multiplex bead analysis[J]. Mol Vis, 2013, 19:2306-2311.
[10] Yang J, Patil RV, Yu H, et al. T cell subsets and sIL-2R/IL-2 levels in patients with glaucoma[J]. Am J Ophthalmol, 2001, 131(4):421-426.
[11] Hautala N, Glumoff V, Hautala T, et al. IL-2 may possess neuroprotective properties in glaucomatous optic neuropathy[J]. Acta Ophthalmol, 2012, 90(3):e246-247.
[12] Gramlich OW, Beck S, Boehm N, et al. Enhanced insight into the autoimmune component of glaucoma: IgG autoantibody accumulation and pro-inflammatory conditions in human glaucomatous retina[J]. PLoS One, 2013, 8(2):e57557.
[13] Agarwal R, Agarwal P. Glaucomatous neurodegeneration: an eye on tumor necrosis factor-alpha[J]. Indian J Ophthalmol. 2012, 60(4):255-261.
[14] Yang Z, Quigley HA, Pease ME, et al. Changes in gene expression in experimental glaucoma and optic nerve transection: the equilibrium between protective and detrimental mechanisms[J]. Invest Ophthalmol Vis Sci, 2007, 48(12):5539-5548.
[15] Fuchs C, Forster V, Balse E, et al. Retinal-cell-conditioned medium prevents TNF-α-induced apoptosis of purified ganglion cells[J]. Invest Ophthalmol Vis Sci, 2005, 46(8):2983-2991.
[16] Tezel G, Wax MB. Increased production of tumor necrosis factor-alpha by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in cocultured retinal ganglion cells[J]. J Neurosci, 2000, 20(23):8693-8700.
[17] Dong N, Xu B, Chu L, et al. Study of 27 aqueous humor cytokines in type 2 diabetic patients with or without macular edema[J]. PLoS One, 2015, 10(4):e0125329.
[18] Sakurada Y, Nakamura Y, Yoneyama S, et al. Aqueous humor cytokine levels in patients with polypoidal choroidal vasculopathy and neovascular age-related macular degeneration[J]. Ophthalmic Res, 2015, 53(1):2-7.
[1] 王新萌,姬俊雅,于浩南,付鸿臣,王翔,郑泽坤,李艳,钟莹莹. 急性闭角型青光眼超声乳化联合房角分离术后屈光预测准确性分析[J]. 山东大学耳鼻喉眼学报, 2026, 40(2): 74-79.
[2] 张婷,王美兰,高映勤. 白细胞介素35在变应性鼻炎中的研究进展[J]. 山东大学耳鼻喉眼学报, 2025, 39(5): 139-147.
[3] 杨臻,孟素坤,张纯. 单眼小梁消融术后对侧眼的眼压同感反应[J]. 山东大学耳鼻喉眼学报, 2024, 38(5): 43-51.
[4] 李洋,马萍,张晗. 不同术式对青光眼术后角膜散光的影响[J]. 山东大学耳鼻喉眼学报, 2024, 38(3): 137-143.
[5] 樊永将,黄卫,何成山,沈海涛,徐正,郝亚楠. SARS-CoV-2感染后成人急性分泌性中耳炎细胞因子水平分析[J]. 山东大学耳鼻喉眼学报, 2024, 38(2): 1-6.
[6] 丁晓敏,崔彦. 新型冠状病毒与眼科相关研究进展[J]. 山东大学耳鼻喉眼学报, 2024, 38(1): 122-127.
[7] 朱玉,朱新华. TH2细胞因子在2型慢性鼻窦炎伴鼻息肉中的作用机制研究进展[J]. 山东大学耳鼻喉眼学报, 2023, 37(5): 156-161.
[8] 孟素坤,张纯. 小梁消融术治疗开角型青光眼患者的长期视野缺损研究[J]. 山东大学耳鼻喉眼学报, 2023, 37(4): 139-148.
[9] 何梦,唐莉. 远程医疗在青光眼诊疗管理中的应用进展[J]. 山东大学耳鼻喉眼学报, 2023, 37(4): 187-195.
[10] 张懿,唐莉. Lowe综合征合并青光眼1例[J]. 山东大学耳鼻喉眼学报, 2023, 37(3): 93-97.
[11] 钟煜, 廖智敏,段宣初. XEN微支架在青光眼手术中的应用进展[J]. 山东大学耳鼻喉眼学报, 2023, 37(1): 145-151.
[12] 石博影,梁皓,李一洪,唐东永. Blau综合征成年患者抗青光眼手术后并发白内障手术治疗1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2022, 36(6): 60-65.
[13] 刘乐乐,孔香云综述申家泉审校. 睫状体分泌功能减弱性手术在青光眼治疗中的进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(6): 123-128.
[14] 唐翡然,孔香云申家泉. 相干光层析血管成像术测量视盘旁浅层血管密度在青光眼诊疗中的作用研究进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(5): 77-82.
[15] 赵颖,张珊许家骏,赵静如. 热休克蛋白72在青光眼视网膜神经节细胞中的保护机制研究进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(5): 83-87.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
网站版权所有 © 2018 《山东大学耳鼻喉眼学报》编辑部　
地址：山东省济南市山大南路27号（250100）电话：+86-0531-88366912 E-mail: ebhxb@sdu.edu.cn
本系统由北京玛格泰克科技发展有限公司设计开发