MIF、GSK-3β在喉鳞状细胞癌中表达的临床意义及相关性研究

doi:10.6040/j.issn.1673-3770.0.2018.423

摘要/Abstract

摘要： 目的探讨巨噬细胞移动抑制因子(MIF)及糖原合成激酶-3(GSK-3β)在喉鳞状细胞癌中表达的临床意义及相关性。方法采用免疫组化法检验30例喉癌患者癌组织及相应癌旁组织中MIF、GSK-3β的表达情况,并以10例非喉鳞状细胞癌患者喉部正常黏膜组织作对照;分析喉组织中MIF、GSK-3β表达与患者临床病理因素之间的关系,探讨喉鳞状细胞癌中MIF与GSK-3β表达的相关性。结果喉癌组织中、癌旁组织及喉正常喉黏膜中MIF表达率分别为73.33%,40.00%,20.00%,喉癌组织中、癌旁组织及喉正常喉黏膜中GSK-3β阳性表达率分别为70.00%,13.33%,20.00%;MIF、GSK-3β在喉癌中表达与肿瘤分化程度、TNM分期及淋巴结转移均相关(P<0.05);与患者年龄、性别、吸烟史和饮酒史均无相关性(P>0.05)。MIF、GSK-3β在喉癌中的表达具有相关性(r=0.592,P=0.003)。结论喉鳞状细胞癌中MIF、GSK-3β的高表达可促进喉癌的发生及发展,MIF、GSK-3β可作为喉癌的潜在的组织生物标志物和喉癌患者疾病进展监控及预后观测的指标。

关键词: 喉肿瘤, 巨噬细胞移动抑制因子, 糖原合成激酶-3, 生物标记物

Abstract: Objective To investigate the clinical significance and correlation of macrophage migration inhibitory factor(MIF)and glycogen synthase kinase-3(GSK-3β)expression in laryngeal squamous cell carcinoma. Methods The expression of MIF and GSK-3β in cancerous tissues and corresponding non-cancerous tissues of 30 patients with laryngeal squamous cell carcinoma were examined by immunohistochemistry and compared with mucosal tissues from 10 patients without laryngeal squamous cell carcinoma. The relationship between MIF and GSK-3β expression in laryngeal tissue and the clinicopathological factors of patients was analyzed. The correlation between MIF and GSK-3β expression in laryngeal squamous cell carcinoma was also investigated. Results The expression rates of MIF in laryngeal carcinoma tissues, adjacent tissues and non-cancerous laryngeal mucosa were 73.33%, 40.00%, 20.00%, respectively. The expression rates of GSK-3β in the three tissue types mentioned above were 70.00%, 13.33%, and 20.00%, respectively. MIF and GSK-3β expression were correlated with tumor differentiation, TNM stage and lymph node metastasis, but not associated with age, gender, smoking history or drinking history (P>0.05). MIF and GSK-3β expression were also correlated with each other (r=0.592, P=0.003). Conclusion Increased MIF and GSK-3β expression can occur in laryngeal squamous cell carcinoma and in laryngeal squamous cell carcinoma disease progression. MIF and GSK-3β may be used as potential biomarkers for laryngeal cancer and as indicators of progression and prognosis during observation and monitoring of laryngeal cancer patients.

Key words: Laryngeal neoplasms, Macrophage migration inhibitory factor, Glycogen synthase kinase-3, Biomarkers

中图分类号:

R767

邹良玉,李连贺,岳文慧,韩志鹏,张子惠. MIF、GSK-3β在喉鳞状细胞癌中表达的临床意义及相关性研究[J]. 山东大学耳鼻喉眼学报, 2019, 33(2): 76-80.

ZOU Liangyu, LI Lianhe, YUE Wenhui, HAN Zhipeng, ZHANG Zihui. Clinical significance and correlation between MIF and GSK-3β expression in laryngeal squamous cell carcinoma[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(2): 76-80.

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