端粒功能障碍诱导ROS促发气道Th2型炎症的机制研究

摘要/Abstract

摘要： 气道Th2型炎症发病率渐长、临床疗效差。端粒功能障碍与气道Th2型炎症性疾病之间存在着一定的关联。目前国内外研究成果表明,端粒功能障碍可以通过驱动线粒体功能障碍、诱导氧化还原失调促使产生活性氧(reactive oxygen species, ROS),进而引起炎症介质级联反应,最终导致Th2型炎症。本文综述了该主题的研究发现,进一步探讨可能的机制,希望以此开发新的干预措施,为相关疾病的研究及治疗提供新思路和新进展。

关键词: 端粒功能障碍, 活性氧, Th2型炎症, 变应性鼻炎, 慢性鼻-鼻窦炎, 哮喘

Abstract: Th2-mediated airway inflammation has emerged as a global health concern due to its increasing prevalence and poor clinical outcomes. A correlation exists between telomere dysfunction and Th2-mediated airway inflammatory diseases. Current research findings from both domestic and international studies indicate that telomere dysfunction can drive mitochondrial dysfunction, induce redox imbalance to promote reactive oxygen species(ROS)production, thereby triggering a cascade of inflammatory mediators, ultimately leading to Th2-mediated inflammation. This paper reviews research findings on the subject and further explores potential mechanisms, with the aim of developing new interventions and providing fresh insights and advances for the study and treatment of related diseases.

Key words: Telomere dysfunction, ROS, Th2-type inflammation, Allergic rhinitis, Chronic rhinosinusitis, Allergic asthma

中图分类号:

R765.21

苏依琳,薛金梅. 端粒功能障碍诱导ROS促发气道Th2型炎症的机制研究[J]. 山东大学耳鼻喉眼学报, 2026, 40(6): 70-75.

SU Yilin, XUE Jinmei. Mechanism of telomere dysfunction inducing ROS-promoted airway Th2-type inflammation[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(6): 70-75.

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