山东大学耳鼻喉眼学报

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定量组织速度成像观察阻塞性睡眠呼吸暂停低通气综合征儿童右心功能的研究

牟鸿1,刘俊杰2,倪彩云3,巩克波1,李东梅1,张建基1,李海燕4   

  1. 1.山东大学齐鲁儿童医院耳鼻喉科, 山东 济南 250022;  2.山东大学附属省立医院口腔颌面外科, 山东 济南 250021;
     3.山东大学齐鲁儿童医院呼吸内科, 山东 济南 250022;  4.山东大学附属济南市中心医院耳鼻喉科, 山东 济南 250013
  • 收稿日期:2013-11-07 出版日期:2014-04-16 发布日期:2014-04-16
  • 作者简介:牟鸿,女,博士。 E-mail:yzmuhong2005@163.com
  • 基金资助:
    济南市卫生局科技计划项目(2008-61)

Evaluation of right ventricular function by quantitative tissue velocity imaging in children with obstructive sleep apea-hypopnea syndrome

MU Hong1, LIU Jun-jie2, NI Cai-yun3, GONG Ke-bo1, LI Dong-mei1, ZHANG Jian-ji1, LI Hai-yan4.   

  1. 1.Department of Otorhinolaryngology, Qilu Children’s Hospital of Shandong University, Jinan 250022, Shandong, China; 2.Department of Oral and maxillofacial Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China; 3. Department of Respiratory Diseaeses, Qilu Children’s Hospital of Shandong University, Jinan 250022, Shandong,  China; 4. Department of Otorhinolaryngology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China
  • Received:2013-11-07 Online:2014-04-16 Published:2014-04-16

摘要: 目的    应用定量组织速度成像(QTVI)评价阻塞性睡眠呼吸暂停低通气综合征(OSAHS)儿童腺样体和(或)扁桃体切除术前、术后右心功能变化,探讨儿童OSAHS对右心功能的影响及QTVI的临床应用价值,确定手术对儿童OSAHS的治疗作用。方法    经多导睡眠监测(PSG)确诊的腺样体肥大和(或)扁桃体肥大的OSAHS儿童55例为实验组,根据呼吸暂停低通气指数(AHI)分为轻度、中度及重度OSAHS组,选取正常对照组20例,应用QTVI技术进行检测。39例中重度OSAHS患儿接受腺样体和(或)扁桃体切除术,术后25例随访6个月再行PSG及QTVI。分析比较各组参数的变化以及与OSAHS的关系。结果    术前中度及重度OSAHS组收缩期峰值速度(Vs) 低于正常对照组,差异均有统计学意义(P<0.05),舒张早期峰值速度(Ve)、舒张晚期峰值速度(Va)及Ve/Va各组间差异无统计学意义(P>0.05)。中重度OSAHS组Vs与AHI呈正相关(R=0.471,P<0.05),与最低血氧饱和度(LSaO2)呈负相关(R=-0.410, P<0.05)。术后6个月AHI明显降低、LSaO2明显升高,而QTVI示Vs升高,均与术前比较差异有统计学意义(P<0.05),与正常对照组间差异无统计学意义(P>0.05)。结论    中重度OSAHS患儿早期有不同程度右室收缩功能下降,三尖瓣环QTVI技术参数能够敏感反映OSAHS患儿右心功能早期改变,在判断右心功能早期变化方面有重要价值。手术切除腺样体和(或)扁桃体是治疗儿童OSAHS的有效方法,可使心肌功能障碍发生逆转。

关键词: 睡眠呼吸暂停, 阻塞性;儿童;定量组织速度成像;右心功能

Abstract:

Objective    To evaluate the early changes of right ventricular function before and after adenoidectomy and/or tonsillectomy in children with obstructive sleep apnea-hypopnea syndrome(OSAHS) by quantitative tissue velocity imaging (QTVI), and investigate the influence of OSAHS on right ventricular function and application of QTVI. Methods    20 normal controls and 55 OSAHS children with adenoid and/or tonsil hypertrophy diagnosed by polysomnography (PSG) were enrolled. According to AHI, the patients were further divided into mild, moderate or severe group. Right ventricular function of all subjects were assessed by OTVI. 39 children with moderate to severe OSAHS underwent adenoidectomy and/or tonsillectomy. After 6 months, 25 children received another PSG and QTVI tests. The data was analyzed. Results    Compared with the normal group, systolic peak velocity(Vs) of the tricuspid annulus were decreased in moderate and severe OSAHS (P<0.05), while the early diastolic peak velocity(Ve)、 late diastolic peak velocity(Va) and ratio of Ve/Va were not (P>0.05). In moderate to severe OSAHS, Vs were positively correlated with AHI (R=0.471, P<0.05), but negatively correlated with LSaO2 (R=0.410, P<0.05). 6 months later after adenoidectomy and/or tonsillectomy, the Vs of tricuspid significantly was increased, while AHI was decreased and LSaO2 was obviously increased (P<0.05). But compared with the normal group, no difference was found (P<0.05). Conclusion    It was demonstrated that the right ventricular systolic function of children with moderate to severe OSAHS decreased to varying degrees at early stage. Tricuspid annular velocity detected by QTVI could reflect sensitively the early changes of right ventricular function. Adenoidectomy and/or tonsillectomy were effective methods to treat childhood OSAHS, which could reverse myocardial dysfunction.

Key words: Right ventricular function, Obstructive sleep apea-hypopnea syndrome, Quantitative tissue velocity imaging, Children

中图分类号: 

  • R766.7
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