DNA双链断裂修复基因的单核苷酸多态性与甲状腺癌的研究进展

doi:10.6040/j.issn.1673-3770.0.2015.391

山东大学耳鼻喉眼学报 ›› 2016, Vol. 30 ›› Issue (2): 102-105.doi: 10.6040/j.issn.1673-3770.0.2015.391

DNA双链断裂修复基因的单核苷酸多态性与甲状腺癌的研究进展

李莹莹^1,2, 宋西成²

1. 滨州医学院临床医学院, 山东烟台 264003;
2. 青岛大学医学院附属烟台毓璜顶医院耳鼻咽喉头颈外科, 山东烟台 264000

收稿日期:2015-09-17 出版日期:2016-04-16 发布日期:2016-04-16
通讯作者: 宋西成. E-mail: songxicheng@126.com E-mail:liyingyingdalian@126.co
作者简介:李莹莹. E-mail: liyingyingdalian@126.co
基金资助:
山东省重点研发计划(2015GSF118090);山东省留学人员科技活动择优资助项目(鲁人社字2013-528号)

Advances on genetic polymorphism of DNA double-strand break repair genes and thyroid carcinoma.

LI Yingying^1,2, SONG Xicheng

1. Binzhou Medical University, Yantai 264000, Shandong, China;2. Department of Otolaryngology &Head and Neck Surgery, Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai 264000, Shandong, China

Received:2015-09-17 Online:2016-04-16 Published:2016-04-16

摘要/Abstract

摘要： 未及时有效修复的DNA损伤,可导致生物体基因组不稳定,这与肿瘤发生有直接关系。DNA双链断裂DSB是基因突变、染色体断裂的主要原因之一,并对肿瘤的易感性、发生、发展具有一定影响,其修复主要是通过HR 和NHEJ 两条重组修复途径完成。综述主要目的是探讨国内外近来研究发现的两种DSB 重组修复机制中修复基因多态性与甲状腺癌易感性之间的联系。

关键词: DNA 双链断裂, 甲状腺癌, 重组修复

Abstract: Failure to repair DNA damage timely and effectively can lead to genome instability, which is directly related to the occurrence of tumor. DNA double-strand break(DSB)is the predominant cause of gene mutation and chromosome fragmentation. It affects the tumor susceptibility and process of carcinogenesis. The DSB repair depends mainly on homologous recombination(HR)and non-homologous end-joining(NHEJ). This paper aims to investigate the correlation between the DSB repair gene polymorphism and thyroid carcinoma susceptibility.

Key words: DNA double-strand break, Recombination repair, Thyroid carcinoma

中图分类号:

R736.1

李莹莹, 宋西成. DNA双链断裂修复基因的单核苷酸多态性与甲状腺癌的研究进展[J]. 山东大学耳鼻喉眼学报, 2016, 30(2): 102-105.

LI Yingying, SONG Xicheng. Advances on genetic polymorphism of DNA double-strand break repair genes and thyroid carcinoma.[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(2): 102-105.

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DNA双链断裂修复基因的单核苷酸多态性与甲状腺癌的研究进展

Advances on genetic polymorphism of DNA double-strand break repair genes and thyroid carcinoma.

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