山东大学耳鼻喉眼学报 ›› 2017, Vol. 31 ›› Issue (2): 55-58.doi: 10.6040/j.issn.1673-3770.0.2016.409

• 论著 • 上一篇    下一篇

探讨同期放化疗对儿童青少年鼻咽癌患者生活质量的影响

陈婷婷1,郭其云2,刘佳琪1,刘丽庭2   

  1. 1.潍坊医学院, 山东 潍坊 261041;
    2.潍坊市人民医院耳鼻喉科, 山东 潍坊 261041
  • 收稿日期:2016-09-22 出版日期:2017-04-16 发布日期:2017-04-16
  • 通讯作者: 刘丽庭. E-mail:liulit62@126.com

Effects of concurrent chemotherapy and radiotherapy on the quality of life in children and adolescents with nasopharyngeal carcinoma.

  1. 1. Weifang Medical College, Weifang 261041, Shandong, China;2. Department of Otolaryngology, Weifang Peoples Hospital, Weifang 261041, Shandong, China
  • Received:2016-09-22 Online:2017-04-16 Published:2017-04-16

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摘要： 目的 探讨同期放化疗对儿童青少年鼻咽癌患者生活质量(QOL)的影响及其不良反应。 方法 通过儿童生存质量普适性核心量表(Peds QLTM4.0)和儿童生存质量癌症模块量表(Peds QLTM3.0)对放化疗治疗的21例儿童青少年鼻咽癌患者进行调查与评估,并对患儿治疗期间的不良反应进行统计分析。 结果 一定周期的放化疗后,患儿的QOL较治疗前均呈下降趋势,Peds QLTM4.0中,患儿的生理功能、情感功能、学校功能3个维度总分均下降(P<0.01),以学校功能影响较为显著,而Peds QLTM3.0中,疼痛、恶心、操作焦虑、认知、交流5 个方面总分均下降,差异均有统计学意义(P<0.01)。放化疗的不良反应主要集中在皮肤损害、口腔黏膜损害、口干、恶心呕吐、白细胞下降等方面。 结论 儿童自我报告的生活质量应受到更多关注,儿童青少年鼻咽癌患者因放化疗而导致的不良反应,可显著影响其生活质量,对不良反应可采取相应措施积极预防。

关键词: 同期放化疗, 生活质量, 鼻咽癌, 青少年, 儿童

Abstract: Objective To investigate the effects of concurrent chemotherapy and radiotherapy on the quality of life and adverse reactions in children and adolescents with nasopharyngeal carcinoma. Methods A total of 21 children and adolescents with nasopharyngeal carcinoma treated with concurrent chemotherapy and radiotherapy were surveyed with Pediatric Quality of Life Inventory 4.0 Generic Core Scales(Peds QLTM4.0)and Pediatric Quality of Life Inventory 3.0 Cancer Module(Peds QLTM3.0)questionnaires. The quality of life scores were calculated and toxic reactions were observed. Results After proper periods of concurrent chemoradiotherapy, patients’ quality of life dropped. In Peds QLTM4.0, the scores of physical, emotional and school functioning dimensions were markedly reduced(P<0.01), especially the school functioning item. In Peds QLTM3.0, such dimensions as pain, nausea, procedure anxiety, cognitive and communication were markedly lowered(P<0.01). Adverse reactions mainly included skin damage, mouth mucitis, dry mouth, nausea, vomiting and neutropenia. Conclusion More attention should be attached to childrens self-reported quality of life. The adverse reactions of concurrent chemoradiotherapy can significantly affect the quality of life. Targeted interventions are supposed to be taken to improve patients’ quality of life.

Key words: Concurrent chemotherapy and radiotherapy, Child, Adolescence, Quality of life, Nasopharyngeal carcinoma

中图分类号: 

  • R739.6
[1] 刘菊英,魏宝清,陆进成,等.145 例儿童及青少年鼻咽癌临床与疗效分析[J]. 中华放射肿瘤学杂志,2003,12(4):234-238. LIU Juying, WEI Baoqing, LU Jincheng, et al. Clinical analysis of radiotherapy for nasopharyngeal carcinoma in 145 children and adolescents[J]. Chin J Radiat Oncol, 2003, 12(4):234-238.
[2] 赖红花.同期放化疗对晚期鼻咽癌患者生活质量的影响[J].中国临床研究,2014,27(12):1471-1473. LAI Honghua. Study on effects of concurrent chemotherapy and radiotherapy on quality of life in advanced nasopharyngeal carcinoma patients[J].Chin J Clin Res, 2014, 27(12):1471-1473.
[3] Irwin DE, Varni JW, Yeatts K, et al. Cognitive interviewing methodology in the development of a pediatric item bank: a patient reported outcomes measurement information system(PROMIS)study[J]. Health Qual Life Outcomes, 2009, 7:3.
[4] Varni JW, Limbers C, Burwinkle TM. Literature review:health-related qua-lity of life measurement in pediatric oncology: hearing the voices of thechildren[J]. J Pediatr Psychol, 2007, 32(9):1151-1163.
[5] 卢奕云,田琪,郝元涛,等.儿童生存质量测定量表Peds QLTM4.0中文版的信度和效度分析[J].中山大学学报(医学科学版),2008,29(3):328-331. LU Yiyun, TIAN Qi, HAO Yuantao, et al. Reliability and validity for chinese version of pediatric quality of life inventory Peds QL4.0[J]. J Sun Yat-sen Univ: Med Sci, 2008, 29(3):328-331.
[6] 张洁文.儿童生存质量癌症模块量表中文版 Peds QL 3.0信度、效度分析及其初步应用[D].广州:中山大学,2009. ZHANG Jiewen. Reliability validity and primary application for chinese version of pediatric quality of life inventory Peds QL3.0[D]. Guangzhou: Sun Yat-sen Univ, 2009.
[7] Vami JW. The Peds QL in pediatric cancer:reliability and va-lidity of the pediatric quality of life inventory generic corescales,multidimensional fatigue scale,and cancer module[J]. Cancer, 2002, 94(7):2090-2106.
[8] Trotti A, Colevas AD, Setser A, et al. CTCAE v3.0: developmentof a comprehensive grading system for the adverse effects of cancertreatment[J]. Semin Radiat Oncol, 2003, 13(3):176-181.
[9] 钱小飞,陈建良. 鼻咽癌临床特征及82例误诊分析[J].山东大学耳鼻喉眼学报,2010,24(4):49-51. QIAN Xiaofei, CHEN Jianliang. Analtsis of clinical presentation and misdiagnosis in patients with nasopharyngeal carcinoma[J]. J Otolaryngol Ophthal of Shandong Univ, 2010, 24(4):49-51.
[10] 徐媛媛,曾泉,洪苏玲,等.新辅助化疗联合同期放化疗与同期放化疗单独治疗鼻咽癌疗效及安全性的 Meta 分析[J].山东大学耳鼻喉眼学报,2013,27(5):9-18. XU Yuanyuan, ZENG Quan, HONG Suling, et al. Comparison of neoadjuvant chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemora-diotherapy alone in locoregionally advanced nasopharyngeal carcinoma: a meta analysis[J]. J Otolaryngol Ophthal Shandong Univ, 2013, 27(5):9-18.
[11] 范长根,韩亚骞,陈艳平,等.同步放化疗治疗72例儿童青少年鼻咽癌临床疗效[J].现代肿瘤医学,2011,19(6):1107-1109. FAN Changgen, HAN Yaqian, CHEN Yanping, et al. Effect of 72 cases of nasopharyngeal carcinoma in children and adolescents treated with concurrent chemoradiotherapy and radiotherapy alone[J]. Modern Oncol, 2011, 19(6):1107-1109.
[12] 张大红,于长华.同期放化疗治疗局部晚期鼻咽癌临床观察[J].山东医药,2011,51(5):72-73. ZHANG Dahong, YU Changhua. Clinical investigation of concurrent chemotherapy and radiotherapy on patients with locally advanced nasopharyngeal carcinoma[J]. Shandong Med J, 2011, 51(5):72-73.
[13] 田野,蔡清淟,岑信棠. 局部晚期鼻咽癌同期放化疗的疗效分析[J]. 中华肿瘤杂志,2005,27(7):429-431. TIAN Ye, CAI Qingtian, CEN Xintang. Concomitant chemo-radiotherapy for locoregionally advanced nasopharygeal carcinoma[J]. Chin J Oncol, 2005, 27(7):429-431.
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