阻塞性睡眠呼吸暂停低通气综合征患者的肺功能变化分析

doi:10.6040/j.issn.1673-3770.0.2022.043

摘要/Abstract

摘要： 目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者肺功能变化情况及其与肥胖的关系。方法回顾性收集烟台毓璜顶医院耳鼻咽喉头颈外科2015年1月-2021年6月的非OSAHS患者及OSAHS患者住院资料共169例,分析患者的肺功能指标及多导睡眠监测(PSG)结果,比较非OSAHS患者与OSAHS患者的肺功能指标,并将OSAHS患者的肺功能指标与PSG结果行相关性分析。结果 OSAHS患者的AHI与BMI呈正相关。最大肺活量(VCmax)、用力肺活量(FVCex)、潮气量(VT)、深吸气量(IC)、第1秒用力呼气量(FEV1)在重度组与非OSAHS组间存在差异。在OSAHS患者中AHI与VCmax、FVCex、PEF、FEV1、IC成负相关,BMI与VCmax、IC、FVCex成负相关。结论 OSAHS患者存在肺功能损害,且在重度患者中更加明显,肥胖可能是导致OSAHS患者肺功能损害的因素之一。

关键词: 阻塞性睡眠呼吸暂停低通气综合征, 肺功能, 肥胖, 通气功能障碍, 多导睡眠监测

Abstract: Objective To investigate the relationship between pulmonary function and obesity in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS). Methods A total of 169 cases of patients with and without OSAHS who were hospitalized in the Department of Otolaryngology & Head and Neck Surgery, Yuhuangding Hospital, Yantai from January 2015 to June 2021 were retrospectively analyzed. Analysis of pulmonary function and polysomnography(PSG)monitoring results and comparison of pulmonary function indicators of the non-OSAHS group and OSAHS group were conducted. The correlation between the pulmonary function indices and PSG results of patients with OSAHS was also identified. Results Apnea-hypopnea index(AHI)and body mass index(BMI)were positively correlated. Maximum vital capacity(Vcmax), forced vital capacity(FVCex), tidal volume(VT), inspiratory capacity(IC), and forced expiratory volume in one second(FEV1)were different between the severe and control groups. AHI was negatively correlated with VCmax, FVCex, PEF, FEV1, and IC. BMI was negatively correlated with VCmax, IC, and FVCex. Conclusion Patients with OSAHS had pulmonary function impairment, which was more apparent in severe patients. Obesity may be a factor leading to pulmonary function impairment in patients with OSAHS.

Key words: Obstructive sleep apnea-hypopnea syndrome, Pulmonary function, Obesity, Ventilatory dysfunction, Polysomnography

中图分类号:

R766.7

李卓君,宋西成,陈秀梅. 阻塞性睡眠呼吸暂停低通气综合征患者的肺功能变化分析[J]. 山东大学耳鼻喉眼学报, 2023, 37(2): 45-50.

LI Zhuojun, SONG Xicheng, CHEN Xiumei. Analysis of pulmonary function changes in patients with obstructive sleep apnea hypopnea syndrome[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(2): 45-50.

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