阻塞性睡眠呼吸暂停与乳腺癌相关性研究进展

doi:10.6040/j.issn.1673-3770.0.2023.342

摘要/Abstract

摘要： 动物实验结果表明,阻塞性睡眠呼吸暂停(obstructive sleep apnea, OSA)所致间歇低氧是乳腺癌发生的危险因素。尽管存在生物合理性,但过去多项临床流行病学研究结果却并不一致。不过,近年发表的一项包括7个大型研究、共5 370 466例患者的荟萃分析结果显示,与无OSA患者相比,OSA患者发生乳腺癌的风险增加36%(HR 1.36,95%CI 1.03~1.80)。论文对此进行介绍,包括临床流行病学研究结果以及可能的发病机制。

关键词: 乳腺癌, 低氧, 发病机制, 阻塞性睡眠呼吸暂停

Abstract: Animal studies suggest that intermittent hypoxia due to obstructive sleep apnea(OSA)is a risk factor for breast cancer. Despite biological plausibility, human epidemiological studies have shown inconsistent results. However, a recent meta-analysis of seven large studies with a total of 5 370 466 patients showed that patients with OSA had a 36% increased risk of breast cancer compared to patients without OSA(HR 1.36, 95%CI 1.03-1.80). This article reviews the research on the relationship between OSA and breast cancer, including the possible pathogenesis of OSA-associated breast cancer.

Key words: Breast cancer, Hypoxia, Mechanism, Obstructive sleep apnea

中图分类号:

R563.9

胡婷婷,王越华. 阻塞性睡眠呼吸暂停与乳腺癌相关性研究进展[J]. 山东大学耳鼻喉眼学报, 2023, 37(6): 41-45.

HU Tingting, WANG Yuehua. Advances in research on the relationship between obstructive sleep apnea and breast cancer[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(6): 41-45.

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