铁死亡在呼吸道炎症性疾病中的作用及研究进展

doi:10.6040/j.issn.1673-3770.0.2022.241

摘要/Abstract

摘要： 铁死亡是一种以铁依赖性脂质过氧化物累积为主要特征的细胞程序性死亡方式。近年来越来越多的研究探索了铁死亡的机制并发现许多分子在调控细胞铁死亡中起着至关重要的作用。新出现的证据表明在哮喘、慢性阻塞性肺疾病、肺纤维化、肺部感染甚至新型冠状病毒肺炎等多种呼吸道炎症性疾病中均存在铁死亡,这表明铁死亡似乎对呼吸道炎症性疾病尤为重要,因此靶向铁死亡机制的药物可能在呼吸道炎症性疾病中具有巨大的治疗前景。论文着重总结铁死亡在呼吸道炎症性疾病中的作用和综合分子机制,提出多角度调控铁死亡可能是临床治疗呼吸道炎症性疾病的一种有前景的策略。

关键词: 铁死亡, 哮喘, 慢性阻塞性肺疾病, 肺炎, 鼻息肉, 变应性鼻炎

Abstract: Ferroptosis is a form of programmed cell death characterized by the accumulation of iron-dependent lipid peroxides. In recent years, more studies have explored the mechanism of ferroptosis, identifying the crucial role of numerous molecules in its regulation. Emerging evidence has identified ferroptosis in various respiratory inflammatory diseases such as asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, pulmonary infections, and even COVID-19, suggesting its crucial role in respiratory inflammatory disorders. Thus, drugs targeting the mechanism of ferroptosis may have significant therapeutic efficacy in respiratory inflammatory diseases. This review focused on the role and molecular mechanism of ferroptosis in respiratory inflammatory diseases, and proposed multi-angle regulation of ferroptosis as a promising potential strategy for their clinical treatment.

Key words: Ferroptosis, Asthma, Chronic obstructive pulmonary disease, Pneumonia, Nasal polyp, Allergic rhinitis

中图分类号:

孙汐文,骆春雨,李志鹏,张维天. 铁死亡在呼吸道炎症性疾病中的作用及研究进展[J]. 山东大学耳鼻喉眼学报, 2023, 37(6): 24-32.

SUN Xiwen, LUO Chunyu, LI Zhipeng, ZHANG Weitian. Role of ferroptosis in inflammatory diseases of the respiratory tract: a review of recent advances[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(6): 24-32.

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