山东大学耳鼻喉眼学报 ›› 2022, Vol. 36 ›› Issue (3): 136-141.doi: 10.6040/j.issn.1673-3770.0.2020.498

• 研究进展 • 上一篇    下一篇

前列腺源性ETS因子在哮喘及鼻黏膜炎性疾病中的研究进展

王娜1,柴向斌2   

  1. 1. 山西医科大学, 山西 太原 030001;
    2. 山西医科大学第一医院 耳鼻咽喉头颈外科, 山西 太原 030001
  • 发布日期:2022-06-15
  • 通讯作者: 柴向斌. E-mail:chaixiangbin@sina.cn

Research progress on prostate-derived ETS factor in asthma and inflammatory diseases of the nasal mucosa

WANG Na1Overview,CHAI Xiangbin2   

  1. 1. Shanxi Medical University, Taiyuan 030001, Shanxi, China;
    2. Department of Otorhinolaryngology & Head and Neck Surgery, the First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, China
  • Published:2022-06-15

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摘要： 含SAM尖端结构域的E26转化特异性因子(SPDEF)是ETS转录因子家族的最新成员之一, SPDEF又称为前列腺源性ETS因子(PDEF),首次发现其在前列腺癌中高度表达,参与肿瘤细胞的增殖分化、迁移凋亡和血管形成。近年来研究发现SPDEF与杯状细胞增生和分化密切相关,是调控呼吸道黏液高分泌的核心因子。对SPDEF调控黏液高分泌的机制及其在呼吸道慢性炎性疾病中的研究进展做一综述,以期为呼吸道黏液高分泌疾病的发病机制和诊治提供新思路。

关键词: 前列腺源性ETS因子, 杯状细胞化生, 黏液高分泌, 气道炎症, 慢性鼻-鼻窦炎, 变应性鼻炎, 哮喘

Abstract: The SAM pointed domain-containing ETS transcription factor(SPDEF), a new member of the E26 transformation-specific(ETS)transcription factor family, SPDEF is also known as prostate-derived ETS factor(PDEF),has been found, for the first time, to be highly expressed in prostate tumor cells and involved in cell proliferation, differentiation, migration, apoptosis, and angiogenesis. Recently, some scholars found that SPDEF is related to the proliferation and differentiation of goblet cells, and it is the core factor that regulates the hypersecretion of the respiratory tract mucus. This article mainly reviews the mechanism underlying the regulation of mucus hypersecretion by SPDEF and the research progress on its involvement in chronic airway inflammatory diseases to provide new insights into the pathogenesis, diagnosis, and treatment of respiratory mucus hypersecretion diseases.

Key words: Prostate-derived ETS factor, Goblet cell metaplasia, Mucus hypersecretion, Airway inflammation, Chronic rhinosinusitis, AR, Asthma

中图分类号: 

  • R765.25
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