环状RNA在变应性鼻炎中的研究进展

doi:10.6040/j.issn.1673-3770.0.2020.393

摘要/Abstract

摘要： 环状RNA(circRNAs)是一类新发现的广泛存在于真核生物中没有5'帽状结构和3'腺苷酸尾的非编码RNA,并可能通过多种影响方式参与生物基因表达调控。例如,近来发现有些 circRNAs 含有微小RNA(miRNAs)相应序列的结合位点,可充当分子海绵,结合 miRNA 并阻断其对mRNA表达的抑制作用。最新研究表明,某些circRNAs 在变应性鼻炎(AR)鼻黏膜中表达丰富,且参与多种AR相关细胞因子的调控,但目前尚未见circRNAs与人类AR严重程度的相关性研究。简述circRNAs的形成机制、特征及生物学功能,阐述circRNAs 的转录后调控与分子海绵作用,综述circRNAs在AR的诊断和治疗方面上的潜力,并为未来AR的研究提供理论支持。

关键词: 环状RNA, 变应性鼻炎, 转录后调控, 分子海绵, 诊断与治疗

Abstract: CircRNAs are newly discovered non-coding RNAs found widely in eukaryotes. They lack the 5' cap structure and 3' adenosine tail. It has been confirmed that circRNAs can regulate gene expression in several ways. For example, we found that some circRNAs contain binding sites of the corresponding sequence in microRNAs. These circRNAs act as molecular sponges to bind miRNAs and intercept their suppressive function on mRNAs. The latest research has showed that some circRNAs expressed at high levels can be found in the nasal mucosa in AR, and that they are involved in the regulation of some cytokines related to AR. However, current research has failed to find a correlation between circRNAs and the degree of severity of AR in humans. In summary, this study evaluated the formation mechanisms, characteristics, and biological functions of circRNAs. The study has also described the post-transcriptional control and “molecular sponges” affect in AR, and it has summarized their potential in the diagnosis and treatment of AR. The study findings provide theoretical support for the analysis of AR in the future.

Key words: circRNAs, AR, Posttranscription regulation, Molecular sponge, Diagnosis and treatment

中图分类号:

R765

刘寨，应民政. 环状RNA在变应性鼻炎中的研究进展[J]. 山东大学耳鼻喉眼学报, 2021, 35(5): 105-112.

LIU Zhai，,YING Minzheng. Research progress on circRNAs in allergic rhinitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(5): 105-112.

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