红光治疗对近视儿童等效球镜度、眼轴长度及脉络膜厚度影响的Meta分析

doi:10.6040/j.issn.1673-3770.0.2023.177

摘要/Abstract

摘要： 目的探讨红光治疗对于近视儿童等效球镜度、眼轴长度及脉络膜厚度的影响。方法检索PubMed、Web of Science、Cochrane Library、Embase、中国知网、万方数据库、中国生物医学文献数据库、维普网、临床试验注册中心从建库至2022年10月28日期间发表的关于红光治疗近视的研究。使用Cochrane手册对纳入文献进行偏倚风险评价及质量评价, 并使用Revman 5.3软件进行Meta分析、STATA 12.0软件检测发表偏倚。结果共计纳入9篇文献(1 425只眼), 其中6项为随机对照试验, 3项为队列研究。Meta分析显示, 红光治疗对等效球镜度(spherical equivalent, SE)及眼轴(axial length, AL)增加的抑制效果好于单光镜治疗(SE:WMD=0.41, 95%CI为0.29~0.54, I2=65%, P<0.000 01;AL:WMD=-0.21, 95%CI为-026~-0.15,I2=73%, P<0.000 01), 红光治疗对脉络膜厚度(choroidal thickness, CHT)的增加优于单光镜治疗(WMD=26.05, 95%CI:22.11~29.99, I2=45%, P<0.000 01)。结论红光治疗疗效优于单光镜治疗, 但长期使用不良反应仍有待进一步观察。

关键词: 红光治疗, 近视, 眼轴, 等效球镜度, 脉络膜厚度, Meta分析

Abstract: Objective To explore the effect of red-light therapy on equivalent sphere, axial length and choroidal thickness in myopic children. Methods We searched PubMed, Web of Science, Cochrane Library, Embase, CNKI, Wanfang, CBM, Vip, and Clinical trial registry on red-light therapy for myopia control published from the establishment of the database to October 28, 2022. The Cochrane Handbook was used for risk of bias and quality evaluation of the included literature, and Revman 5.3 software was used for Meta-analysis, and STATA 12.0 software was used to detect publication bias. Results A total of 1425 eyes from nine articles were included, of which five were randomized controlled trials and three were control studies. Meta-analysis showed that the inhibitory effect of red-light on the increase in spherical equivalent(SE)and axial length(AL)was better than that of the single-focus spectacles group(SE: WMD=0.41, 95%CI: 0.29-0.54, I2=65%, P<0.000 01; AL: WMD=-0.21, 95%CI: -026 - 0.15, I2=73%, P<0.000 01), the increase of choroidal thickness(CHT)in red-light therapy group was superior to that in single-focus spectacles group(WMD=26.05, 95%CI: 22.11-29.99, I2=45%, P<0.000 01). Conclusion The control effect of red-light therapy was better than that of the single-focus spectacles, but long-term use of adverse reations still need to be further observed.

Key words: Red-light therapy, Myopia, Axis length, Spherical equivalent, Choroidal thickness, Meta-analysis

中图分类号:

R778.1

李飏,刘鸫,曹文捷. 红光治疗对近视儿童等效球镜度、眼轴长度及脉络膜厚度影响的Meta分析[J]. 山东大学耳鼻喉眼学报, 2024, 38(3): 74-81.

LI Yang, LIU Dong, CAO Wenjie. Meta-analysis of the effect of red-light therapy on spherical equivalent, axial length, and choroidal thickness in myopic children[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 74-81.

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