山东大学耳鼻喉眼学报 ›› 2023, Vol. 37 ›› Issue (6): 145-152.doi: 10.6040/j.issn.1673-3770.0.2023.226
袁晨阳1,2,冯晨3,王岩4,李延忠4,房振胜2
YUAN Chenyang1,2, FENG Chen3, WANG Yan4, LI Yanzhong4, FANG Zhensheng2
摘要: 目的 探讨阻塞性睡眠呼吸暂停(obstructive sleep apnea, OSA)儿童与健康儿童血液学指标的差异及不同严重程度和不同临床表型的OSA患儿血液学指标的变化情况,为儿童OSA的诊断及精准治疗提供理论支持。 方法 纳入因睡眠打鼾就诊于耳鼻咽喉科确诊为OSA的76例患儿和37例对照组儿童。收集OSA儿童的病史及影像学检查及两组儿童的体格检查、睡眠呼吸监测结果、外周血指标:WBC、HB、ANC、ALC、PLT、MPV、PDW、RDW、NLR、PLR等。 结果 OSA患儿的血液指标WBC、ANC、ALC、HB、NLR、PLR、PLT、MPV较正常儿童高,其中RDW存在较为差异显著统计学意义(P=0.001)。在OSA患儿不同严重程度亚组之间,WBC、ANC、ALC、NLR、RDW、PLT水平随OSA程度加重而升高,其中WBC、ANC、NLR差异有统计学意义(P<0.001; P<0.001; P=0.017)。腺样体显著肥大组患儿的WBC、ANC、NLR较病理肥大组、中度肥大组及正常组显著升高,其中ANC、NLR指标差异有统计学意义(P=0.014; P=0.015)。 结论 外周血相关炎性指标可作为临床医师辅助检查、预测、评估儿童OSA病情严重程度的重要指标。WBC、ANC、NLR是临床上简便易得的指标,作为儿童OSA严重程度及机体炎症水平的潜在预测因子。
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