山东大学耳鼻喉眼学报 ›› 2024, Vol. 38 ›› Issue (4): 140-148.doi: 10.6040/j.issn.1673-3770.0.2024.181
• 综述 • 上一篇
张静祎1,2,董湘依3,牟亚魁1,宋西成1
ZHANG Jingyi1,2, DONG Xiangyi3, MU Yakui1, SONG Xicheng1
摘要: 细胞焦亡作为程序性细胞死亡方式中的一种,其过程离不开caspase家族和gasdermin家族,同时伴随着炎性反应的发生,其主要过程是caspase家族被激活后作用于gasdermin家族N端结构,通过易位插入细胞膜表面、寡聚等方式使得细胞膜裂孔形成后体积逐渐膨胀,最终细胞膜破裂,细胞里面的物质从细胞内释放出来,诱发机体产生强烈的炎症性反应。近几年,细胞焦亡为耳鼻咽喉科研究的热点方向之一。本文主要综述细胞焦亡的发现历程、分子机制及其在慢性鼻窦炎、变应性鼻炎、鼻咽癌、听力损失、头颈部肿瘤等耳鼻咽喉科常见疾病中的研究进展。
中图分类号:
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