紧密连接与慢性鼻-鼻窦炎发病机制的研究进展

doi:10.6040/j.issn.1673-3770.0.2017.042

摘要/Abstract

摘要： 慢性鼻-鼻窦炎(CRS)是常见的鼻腔鼻窦黏膜炎症性疾病。紧密连接是位于上皮细胞连接的最顶部的连接蛋白复合体,在维持上皮细胞屏障功能上发挥重要的作用。研究表明,紧密连接蛋白缺陷和CRS发病机制存在关联。紧密连接蛋白组成及其与CRS的关系已经成为当前的研究热点,综述其研究进展。

关键词: 紧密连接, 慢性鼻-鼻窦炎

Abstract: Chronic rhinosinusitis(CRS)is a common inflammatory disease. TJs are the most apically located of the intercellular junctional complexes, and may have critical role in barrier function of epithelium. Found in the recent years, the changes of tight junctions(TJs)may play important roles in the pathogenesis of chronic rhinosinusitis. The component of TJs are the spot-light in current area of research. This review article explores the pathogenesis of CRS, especially the tight junctions, for the sake of further understanding of CRS.

Key words: Tight junctions, Chronic rhinosinusitis

中图分类号:

R765.4

康雪综述, 叶菁审校. 紧密连接与慢性鼻-鼻窦炎发病机制的研究进展[J]. 山东大学耳鼻喉眼学报, 2017, 31(2): 112-115.

参考文献

[1] Azizzadeh DA, Jalali NM, Davati A, et al. Expression of vascular endothelial growth factor in nasal polyp and chronic rhinosinusitis[J]. Iran J Pathol, 2016, 11(3):231-237.
[2] London NR, Tharakan A, Ramanathan M. The role of innate immunity and aeroallergens in chronic rhinosinusitis[J]. Adv Otorhinolaryngol, 2016, 79:69-77.
[3] Hulse KE. Immune Mechanisms of Chronic Rhinosinusitis[J]. Curr Allergy Asth Rep, 2016, 16(1):1-8.
[4] Chang EH, Pezzulo AA, Zabner J. Do Cell Junction Protein Mutations Cause an Airway Phenotype in Mice or Humans?[J]. Am J Resp Cell Mol Biol, 2011, 45(2):202-220.
[5] Wei Y, Han M, Wen W, et al. Differential short palate, lung, and nasal epithelial clone 1 suppression in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps: implications for pathogenesis and treatment[J]. Curr Opin Allergy Clin Immunol, 2015, 16(1):31-38.
[6] Rogers GA, Den BK, Parkos CA, et al. Epithelial tight junction alterations in nasal polyposis[J]. Int Forum Allergy Rhinol, 2011, 1(1):50-54.
[7] Turner JR, Buschmann MM, Sailer A, et al. The role of molecular remodeling in differential regulation of tight junction permeability[J]. Semin Cell Develop Biol, 2014, 36(2):204-212.
[8] Itallie CMV, Anderson JM. Architecture of tight junctions and principles of molecular composition[J]. Semin Cell Develop Biol, 2014, 36(1):157-165.
[9] Soini Y. Tight junctions in lung cancer and lung metastasis: a review[J]. Int J Clin Exp Pathol, 2012, 5(2):126-136.
[10] Anderson JM, Van Itallie CM. Physiology and function of the tight junction[J]. Cold Spring Harbor Perspect Biol, 2009, 1(2):a002584.
[11] Dokladny K, Zuhl MN, Moseley PL. Intestinal epithelial barrier function and tight junction proteins with heat and exercise[J]. J App Physiol, 2015, 120(6):692-701.
[12] Kim HJ, Cronin M, Ahrens K, et al. A comparative study of epidermal tight junction proteins in a dog model of atopic dermatitis[J]. Veterin Dermatol, 2015, 27(1):40-e11.
[13] Park SW, Kim JH, Park SM, et al. RAGE mediated intracellular Aβ uptake contributes to the breakdown of tight junction in retinal pigment epithelium[J]. Oncotarget, 2015, 6(34):35263-35273.
[14] Swindle EJ, Collins JE, Davies DE. Breakdown in epithelial barrier function in patients with asthma: identification of novel therapeutic approaches[J]. J Allergy Clin Immunol, 2009, 124(1):35-36.
[15] Li Y, Wang X, Wang R, et al. The expression of epithelial intercellular junctional proteins in the sinonasal tissue of subjects with chronic rhinosinusitis: a histopathologic study[J]. ORL, 2014, 76(2):110-119.
[16] Kojima T, Go M, Takano K, et al. Regulation of tight junctions in upper airway epithelium[J]. Biomed Res Int, 2013, 2013(2):947072.
[17] Günzel D, Yu AS. Claudins and the modulation of tight junction permeability[J]. Physiol Rev, 2013, 93(2): 525-569.
[18] Steelant B, Seys SF, Boeckxstaens G, et al. Restoring airway epithelial barrier dysfunction: a new therapeutic challenge in allergic airway disease[J]. Rhinol, 2016, 54(3):195-205.
[19] Wise SK, Laury AM, Katz EH, et al. Interleukin-4 and interleukin-13 compromise the sinonasal epithelial barrier and perturb intercellular junction protein expression[J]. Int Forum Allergy Rhinol, 2014, 4(5):361-370.
[20] Chen X, Luo X, Han M, et al. Corticosteroid regulates epithelial occludin expression in nasal polyps through a mkp-1-dependent pathway[J]. ORL, 2014, 76(5):248-256.
[21] Philip M. Occludin: one protein, many forms[J]. Cummins Mol Cell Biol, 2012, 32(2): 242-250.
[22] Phattarataratip E, Sappayatosok K. Expression of claudin-5, claudin-7 and occludin in oral squamous cell carcinoma and their clinico-pathological significance[J]. J Clin Exper Dent, 2016, 8(3):299-306.
[23] Chen Y, Zhang HS, Fong GH, et al. PHD3 stabilizes the tight junction protein occludin and protects intestinal epithelial barrier function[J]. J Biol Chem, 2015, 290(33):20580-20589.
[24] Zhao H, Zhao C, Dong Y, et al. Inhibition of miR122a by lactobacillus rhamnosus GG culture supernatant increases intestinal occludin expression and protects mice from alcoholic liver disease[J]. Toxicol Lett, 2015, 234(3):194-200.
[25] Xia YP, He QW, Li YN, et al. Recombinant human sonic hedgehog protein regulates the expression of ZO-1 and occludin by activating angiopoietin-1 in stroke damage[J]. Plos One, 2013, 8(7):e68891.
[26] Soyka MB, Wawrzyniak P, Eiwegger T, et al. Defective epithelial barrier in chronic rhinosinusitis: the regulation of tight junctions by IFN-γ and IL-4[J]. J Allergy Clin Immunol, 2012, 130(5):1087-1096.
[27] Meng J, Zhou P, Liu Y, et al. The development of nasal polyp disease involves early nasal mucosal inflammation and remodelling[J]. Plos One, 2013, 8(12):e82373.
[28] Nomura K, Obata K, Keira T, et al. Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells[J]. Respirat Res, 2014, 15(1):21-33.
[29] Garridourbani S, Bradfield PF, Imhof BA. Tight junction dynamics: the role of junctional adhesion molecules(JAMs)[J]. Cell Tissue Res, 2014, 355(3):701-715.
[30] Arcangeli ML, Frontera V, Aurrandlions M. Function of junctional adhesion molecules(JAMs)in leukocyte migration and homeostasis[J]. Arch Immunol Et Ther Exper, 2012, 61(1):15-23.
[31] Monteiro AC, Parkos CA. Intracellular mediators of JAM-A-dependent epithelial barrier function[J]. Ann New York Acad Sci, 2012, 1257(1):115-124.
[32] Den Beste KA, Hoddeson EK, Parkos CA, et al. Epithelial permeability alterations in an in vitro air–liquid interface model of allergic fungal rhinosinusitis [J]. Int Forum Allergy Rhinol, 2013, 3(1):19-25.
[33] Mariano C, Sasaki H, Brites D, et al. A look at tricellulin and its role in tight junction formation and maintenance[J]. Eur J Cell Biol, 2011, 90(10):787-796.
[34] Takasawa A, Kojima T, Ninomiya T, et al. Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions[J]. Cell Tissue Res, 2013, 351(1):73-84.
[35] Mandon M, Cyr DG. Tricellulin and its role in the epididymal epithelium of the rat[J]. Biol Reprod, 2015, 92(3):66.
[36] Ohkuni T, Kojima T, Ogasawara N, et al. Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro[J]. Med Molec Morphol, 2009, 42(4):204-211.
[37] Suzuki H, Koizumi H, Ikezaki S, et al. Electrical Impedance and Expression of Tight Junction Components of the Nasal Turbinate and Polyp[J]. ORL, 2015, 78(1):16-25.
[38] Zimmerman SP, Hueschen CL, Malide D, et al. Sorting nexin 27(SNX27)associates with zonula occludens-2(ZO-2)and modulates the epithelial tight junction[J]. Biochem J, 2013, 455(1):95-106.
[39] 李颖, 范尔钟, 伯铭羽,等. 细胞连接在慢性鼻窦炎中的表达及意义[J]. 首都医科大学学报, 2013, 34(6):799-804. LI Ying, FAN Erzhong, BO Mingyu, et al. Expression of cell junctions in the tissue of chronic rhinosinusitis[J]. J Capital Med Univ, 2013, 34(6):799-804.

相关文章 15

[1]	龚齐,张劼,赵屏屏. 鼻腔扩容术对慢性鼻-鼻窦炎伴睡眠呼吸暂停[J]. 山东大学耳鼻喉眼学报, 2018, 32(2): 52-55.
[2]	林兴,林宗通,沈翎. 鼻窦球囊扩张治疗儿童慢性鼻窦炎的系统评价及Meta分析[J]. 山东大学耳鼻喉眼学报, 2017, 31(6): 79-86.
[3]	伦杰,张亚楠. 慢性鼻-鼻窦炎伴鼻息肉复发的相关影响因素分析[J]. 山东大学耳鼻喉眼学报, 2017, 31(3): 80-83.
[4]	苏怡,谢景华,潘晓李,曾国庆. 慢性鼻-鼻窦炎伴或不伴鼻息肉患者鼻内镜手术的疗效及影响因素分析[J]. 山东大学耳鼻喉眼学报, 2016, 30(4): 86-89.
[5]	谢朝峰,林宏浩. 慢性鼻-鼻窦炎手术预后的临床影响因素分析[J]. 山东大学耳鼻喉眼学报, 2016, 30(4): 90-93.
[6]	訾晓雪,赵莉,金鹏,屠燕怡,李昂,史丽. 伴有嗅觉障碍的慢性鼻-鼻窦炎患者鼻内镜术后嗅觉及生活质量转归的研究[J]. 山东大学耳鼻喉眼学报, 2016, 30(1): 21-25.
[7]	吴青松,曾蓉,刘明娜,洪潮鑫,刘绪光,邓伟锋,周凤平. 慢性鼻-鼻窦炎患者药物治疗的生存质量及相关研究[J]. 山东大学耳鼻喉眼学报, 2016, 30(1): 26-30.
[8]	王志远, 张革化. 慢性鼻-鼻窦炎小鼠模型及应用现状[J]. 山东大学耳鼻喉眼学报, 2015, 29(5): 76-78.
[9]	谭建成. 慢性鼻-鼻窦炎病变程度与支气管哮喘肺功能的相关性[J]. 山东大学耳鼻喉眼学报, 2015, 29(1): 28-31.
[10]	刘娜,闫娟,刘涛. 慢性鼻-鼻窦炎的免疫机制研究进展[J]. 山东大学耳鼻喉眼学报, 2014, 28(3): 86-88.
[11]	刘阳云1，陈志喜2，江文1，李正贤1，毛坤华1 . 不同的评估指标在鼻咽癌放疗后慢性鼻-鼻窦炎治疗方案选择和疗效评估中的价值[J]. 山东大学耳鼻喉眼学报, 2014, 28(1): 22-26.
[12]	李雪盛,钱进,李厚恩综述,李进让审校. 慢性鼻-鼻窦炎的组织重塑研究进展[J]. 山东大学耳鼻喉眼学报, 2014, 28(1): 84-86.
[13]	刘阳云,李正贤,江文,毛坤华,陈琼,常恩格. VAS评分对鼻咽癌放疗后慢性鼻-鼻窦炎治疗方案选择的价值[J]. 山东大学耳鼻喉眼学报, 2013, 27(4): 66-69.
[14]	刘亦青,李红,纪宏志,何明强,时光刚. 165例慢性鼻-鼻窦炎患者变应性相关临床资料分析[J]. 山东大学耳鼻喉眼学报, 2011, 25(6): 74-.
[15]	韩学锋，张磊，魏晓，李学忠. IL-17在慢性鼻-鼻窦炎患者血浆中的表达及其意义[J]. 山东大学耳鼻喉眼学报, 2011, 25(3): 58-61.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed