线粒体自噬与头颈部鳞状细胞癌关系的研究进展

doi:10.6040/j.issn.1673-3770.0.2022.147

摘要/Abstract

摘要： 头颈部鳞状细胞癌(head and neck squamous cell carcinoma, HNSCC)是全球最常见的6种癌症之一,很多晚期患者因肿瘤复发或对化疗药物耐药而死亡。努力开拓治疗HNSCC新策略,对于HNSCC患者的预后具有重大意义。线粒体自噬是一种选择性的宏观自噬形式,通过相关通路蛋白或者药物调控减轻氧化应激和预防癌的发生,又或者在一些不利条件下促进肿瘤细胞的存活。目前大量研究证明,线粒体自噬是控制癌细胞质量的关键因素,与肿瘤发生发展密切相关。线粒体功能障碍促进细胞癌变;线粒体自噬功能失调可诱导癌细胞凋亡;新型药物的出现开拓了靶向线粒体治疗肿瘤的新方法,线粒体自噬对于肿瘤的防治展现出巨大潜能。论文将从线粒体自噬的调控机制、线粒体自噬与肿瘤的关系、HNSCC防治及临床耐药性等方面进行综述,旨在为HNSCC治疗提供新的方向和靶点。

关键词: 线粒体自噬, 头颈部鳞状细胞癌, 氧化应激, 线粒体功能障碍, 调控机制, 临床耐药性

Abstract: Head and neck squamous cell carcinoma(HNSCC)is among the six most common cancers worldwide. Many patients in advanced stages of HNSCC die because of tumor recurrence or resistance to chemotherapy drugs. New treatment strategies are needed to improve the prognosis of HNSCC patients. Mitochondrial autophagy is a selective form of macro autophagy which reduces oxidative stress and prevents cancer by regulating related pathway proteins or drugs, or by promoting the survival of tumor cells under some adverse conditions. Mitochondrial autophagy is the key factor to control the quality of cancer cells which is closely related to the occurrence and development of cancer. Mitochondrial dysfunction promotes cell carcinogenesis, and mitochondrial autophagy dysfunction can induce apoptosis of cancer cells. The discovery and development of new drugs has created new options in targeting mitochondria to treat tumors. Mitochondrial autophagy shows great potential for the prevention and treatment of tumors. This article reviews the regulatory mechanism of mitochondrial autophagy, relationship between mitochondrial autophagy and tumor, and prevention and treatment of HNSCC and clinical drug resistance. The aim of this study is to provide new research directions and targets for the treatment of HNSCC.

Key words: Mitochondrial autophagy, Head and neck squamous cell carcinoma, Oxidative stress, Mitochondrial dysfunction, Regulatory mechanism, Clinical resistance

中图分类号:

R739.9

索安奇,杨欣欣. 线粒体自噬与头颈部鳞状细胞癌关系的研究进展[J]. 山东大学耳鼻喉眼学报, 2023, 37(3): 111-117.

SUO Anqi, YANG Xinxin. Research progress on the relationship between mitochondrial autophagy and squamous cell carcinoma of the head and neck[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(3): 111-117.

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