山东大学耳鼻喉眼学报 ›› 2025, Vol. 39 ›› Issue (6): 160-167.doi: 10.6040/j.issn.1673-3770.0.2024.061

• 综述 • 上一篇    

鼻用糖皮质激素在儿童中的应用

熊琴1, 张砚1, 乌日娜1, 李锋1, 唐力行2   

  1. 1. 北京儿童医院新疆医院/新疆维吾尔自治区儿童医院 耳鼻咽喉科, 新疆 乌鲁木齐 830000;
    2. 国家儿童医学中心/首都医科大学附属北京儿童医院 耳鼻咽喉头颈外科, 北京 100045
  • 发布日期:2025-11-19
  • 通讯作者: 唐力行. E-mail:laotang1971@sina.com

Application of intranasal corticosteroids in pediatrics

XIONG Qin1, ZHANG Yan1, WU Rina1, LI Feng1, TANG Lixing2   

  1. 1. Department of Otorhinolaryngology, Children's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Hospital of Beijing Children's Hospital, Urumqi 830000, Xinjiang, China 2. Department of Otorhinolaryngology & Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China
  • Published:2025-11-19

摘要: 鼻用糖皮质激素(intranasal corticosteroids, INCS)是成分中含有糖皮质激素的各种喷鼻剂,是目前治疗变应性鼻炎、轻中度慢性鼻窦炎的一线首选治疗药物。它有明显的局部抗炎、减轻水肿的作用,可促使病变的鼻黏膜恢复至正常,临床上能有效缓解患者的鼻塞、流涕和喷嚏等症状。由于局部用药的安全性和耐受性优势,近年来INCS在儿童阻塞性睡眠呼吸暂停、腺样体肥大、分泌性中耳炎等疾病中也得到了应用。笔者对近年来有关INCS应用的情况进行了汇总,并针对临床上关注的几个问题进行综述。

关键词: 鼻用糖皮质激素, 变应性鼻炎, 慢性鼻窦炎, 阻塞性睡眠呼吸暂停, 儿科, 临床用药

Abstract: Intranasal corticosteroids(INCS)are various nasal sprays containing glucocorticoids and are currently the first-line treatment for allergic rhinitis and mild-to-moderate chronic sinusitis. They have significant local anti-inflammatory effects, reduce oedema and can restore normal nasal mucosa, effectively relieving symptoms such as nasal congestion, runny nose and sneezing in patients. Due to the safety and tolerability advantages of local medication, INCS has also been used in recent years for conditions such as paediatric obstructive sleep apnoea, adenoid hypertrophy and secretory otitis media. The use of INCS in recent years is summarised and several issues of clinical concern are discussed.

Key words: Intranasal corticosteroids, Allergic rhinitis, Chronic sinusitis, Obstructive sleep apnea, Paediatrics, Clinical medication

中图分类号: 

  • R762
[1] 王睿坤, 梁洁琼, 韩伟, 等. 2001—2021年中国儿童青少年过敏性鼻炎患病率的Meta分析[J]. 中华预防医学杂志, 2022, 56(6): 784-793. doi:10.3760/cma.j.cn112150-20220315-00242 WANG Ruikun, LIANG Jieqiong, HAN Wei, et al. Prevalence of allergic rhinitis in Chinese children from 2001 to 2021: Meta analysis[J]. Chinese Journal of Preventive Medicine, 2022, 56(6): 784-793. doi:10.3760/cma.j.cn112150-20220315-00242
[2] He S, Li YJ, Chen J. Clinical features of allergic rhinitis in children of Shanghai, China[J]. Genet Mol Res, 2016, 15(2): GMRvol.15, 210.4238/gmr.15028118.9May.2016,. doi:10.4238/gmr.15028118
[3] Shi JB, Fu QL, Zhang H, et al. Epidemiology of chronic rhinosinusitis: results from a cross-sectional survey in seven Chinese cities[J]. Allergy, 2015, 70(5): 533-539. doi:10.1111/all.12577
[4] Levy JM, Mace JC, DeConde AS, et al. Improvements in psychological dysfunction after endoscopic sinus surgery for patients with chronic rhinosinusitis[J]. Int Forum Allergy Rhinol, 2016, 6(9): 906-913. doi:10.1002/alr.21776
[5] 倪鑫. 中国儿童阻塞性睡眠呼吸暂停诊断与治疗指南(2020)[J]. 中国循证医学杂志, 2020, 20(8): 883-900. doi:10.7507/1672-2531.202005147 NI Xin. Chinese Guidelines for diagnosis and treatment of obstructive sleep apnea in children(2020)[J]. Chinese Journal of Evidence-Based Medicine, 2020, 20(8): 883-900. doi: 10.7507/1672-2531.202005147
[6] Faramarzi A, Kadivar MR, Heydari ST, et al. Assessment of the consensus about tonsillectomy and/or adenoidectomy among pediatricians and otolaryngologists[J]. Int J Pediatr Otorhinolaryngol, 2010, 74(2): 133-136. doi:10.1016/j.ijporl.2009.10.024
[7] Wang DE, Lam DJ, Bellmunt AM, et al. Intranasal steroid use for otitis media with effusion: ongoing opportunities for quality improvement[J]. Otolaryngol Head Neck Surg, 2017, 157(2): 289-296. doi:10.1177/0194599817703046
[8] Hu SJ, Wei P, Kou W, et al. Prevalence and risk factors of allergic rhinitis: a Meta-analysis[J]. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2017, 31(19): 1485-1491. doi:10.13201/j.issn.1001-1781.2017.19.006
[9] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科学组. 变应性鼻炎诊断和治疗指南(2015年,天津)[J]. 中华耳鼻咽喉头颈外科杂志, 2016, 51(1): 6-24. doi:10.3760/cma.j.issn.1673-0860.2016.01.004
[10] Meltzer EO. The pharmacological basis for the treatment of perennial allergic rhinitis and non-allergic rhinitis with topical corticosteroids[J]. Allergy, 2008, 52: 33-40. doi:10.1111/j.1398-9995.1997.tb04820.x
[11] Fokkens WJ, Lund VJ, Hopkins C, et al. European position paper on rhinosinusitis and nasal polyps 2020[J]. Rhinology, 2020, 58(29): 1-464. doi:10.4193/Rhin20.600
[12] Wang CS, Cheng L, Li HB, et al. Chinese expert recommendation on transnasal corticosteroid nebulization for the treatment of chronic rhinosinusitis 2021[J]. J Thorac Dis, 2021, 13(11): 6217-6229. doi:10.21037/jtd-21-1142
[13] Xie YQ, Ju XT, Beaudin S, et al. Effect of intranasal corticosteroid treatment on allergen-induced changes in group 2 innate lymphoid cells in allergic rhinitis with mild asthma[J]. Allergy, 2021, 76(9): 2797-2808. doi:10.1111/all.14835
[14] Baroody FM, Cruz AA, Lichtenstein LM, et al. Intranasal beclomethasone inhibits antigen-induced nasal hyperresponsiveness to histamine[J]. J Allergy Clin Immunol, 1992, 90(1): 373-376. doi:10.1016/s0091-6749(05)80017-x
[15] Hughes K, Glass C, Ripchinski M, et al. Efficacy of the topical nasal steroid budesonide on improving sleep and daytime somnolence in patients with perennial allergic rhinitis[J]. Allergy, 2003, 58(5): 380-385. doi:10.1034/j.1398-9995.2003.00093.x
[16] Day J, Carrillo T. Comparison of the efficacy of budesonide and fluticasone propionate aqueous nasal spray for once daily treatment of perennial allergic rhinitis[J]. J Allergy Clin Immunol, 1998, 102(1): 902-908. doi:10.1016/s0091-6749(98)70326-4
[17] Juniper EF, Guyatt GH, Archer B, et al. Aqueous beclomethasone dipropionate in the treatment of ragweed pollen-induced rhinitis: further exploration of “as needed” use[J]. J Allergy Clin Immunol, 1993, 92(1): 66-72. doi:10.1016/0091-6749(93)90039-i
[18] Penagos M, Compalati E, Tarantini F, et al. Efficacy of mometasone furoate nasal spray in the treatment of allergic rhinitis. Meta-analysis of randomized, double-blind, placebo-controlled, clinical trials[J]. Allergy, 2008, 63(10): 1280-1291. doi:10.1111/j.1398-9995.2008.01808.x
[19] Rachelefsky G, Farrar JR. A control model to evaluate pharmacotherapy for allergic rhinitis in children[J]. JAMA Pediatr, 2013, 167(4): 380-386. doi:10.1001/jamapediatrics.2013.623
[20] Meltzer EO, Munafo DA, Chung W, et al. Intranasal mometasone furoate therapy for allergic rhinitis symptoms and rhinitis-disturbed sleep[J]. Ann Allergy Asthma Immunol, 2010, 105(1): 65-74. doi:10.1016/j.anai.2010.04.020
[21] Herman H. Once-daily administration of intranasal corticosteroids for allergic rhinitis: a comparative review of efficacy, safety, patient preference, and cost[J]. Am J Rhinol, 2007, 21(1): 70-79. doi:10.2500/ajr.2007.21.2896
[22] Máspero JF, Rosenblut A, Finn A Jr, et al. Safety and efficacy of fluticasone furoate in pediatric patients with perennial allergic rhinitis[J]. Otolaryngol Head Neck Surg, 2008, 138(1): 30-37. doi:10.1016/j.otohns.2007.10.023
[23] McDonnell J, Weller K, Pien LC. Safety of intranasal steroids: an updated perspective[J]. Curr Allergy Asthma Rep, 2020, 20(11): 69. doi:10.1007/s11882-020-00960-2
[24] Minshall E, Ghaffar O, Cameron L, et al. Assessment by nasal biopsy of long-term use of mometasone furoate aqueous nasal spray(Nasonex)in the treatment of perennial rhinitis[J]. Otolaryngol Head Neck Surg, 1998, 118(5): 648-654. doi:10.1177/019459989811800514
[25] Ahmadi N, Snidvongs K, Kalish L, et al. Intranasal corticosteroids do not affect intraocular pressure or lens opacity: a systematic review of controlled trials[J]. Rhinology, 2015, 53(4): 290-302. doi:10.4193/Rhino15.020
[26] Bérard A, Sheehy O, Kurzinger ML, et al. Intranasal triamcinolone use during pregnancy and the risk of adverse pregnancy outcomes[J]. J Allergy Clin Immunol, 2016, 138(1): 97-104.e7. doi:10.1016/j.jaci.2016.01.021
[27] Mener DJ, Shargorodsky J, Varadhan R, et al. Topical intranasal corticosteroids and growth velocity in children: a meta-analysis[J]. Int Forum Allergy Rhinol, 2015, 5(2): 95-103. doi:10.1002/alr.21430
[28] Nowicka A, Samoliński B. Is the use of intranasal glucocorticosteroids(inGCSs)in children safe?[J]. Otolaryngol Pol, 2015, 69(1): 1-10. doi:10.5604/00306657.1136130
[29] Jang TY, Kim YH. Recent updates on the systemic and local safety of intranasal steroids[J]. Curr Drug Metab, 2016, 17(10): 992-996. doi:10.2174/1389200218666161123123516
[30] Badorrek P, Hohlfeld JM, Krug N, et al. Efficacy and safety of a novel nasal steroid, S0597, in patients with seasonal allergic rhinitis[J]. Ann Allergy Asthma Immunol, 2015, 115(4): 325-329. doi:10.1016/j.anai.2015.07.016
[31] Hopkins C. Chronic rhinosinusitis with nasal polyps[J]. New England Journal of Medicine, 2019, 381(1): 55-63. doi:10.1056/nejmcp1800215
[32] 王松, 王玲玲, 张华. 鼻用激素类药物在儿童急性分泌性中耳炎治疗中的应用[J]. 新疆医学, 2019, 49(2): 3 WANG Song, WANG Lingling, ZHANG Hua. Application of nasal hormone drugs in the treatment of acute secretory otitis media in children[J]. Xinjiang Medicine, 2019, 49(2): 3
[33] 马思捷, 郭玉芬. 国内外儿童分泌性中耳炎指南中治疗方式的比较[J]. 听力学及言语疾病杂志, 2023, 31(3): 271-274. doi:10.3969/j.issn.1006-7299.2023.03.016
[34] 中国医师协会儿科医师分会儿童耳鼻咽喉专业委员会. 儿童过敏性鼻炎诊疗——临床实践指南[J]. 中国实用儿科杂志, 2019, 34(3): 169-175. doi:10.19538/j.ek2019030601 Pediatric otorhinolaryngology Committee, Pediatrician Branch of Chinese Medical Doctor Association. Children allergic rhinitis diagnosis and treatment, clinical practice guidelines [J]. Chinese journal of practical pediatrics, 2019, 34(3): 169-175. doi:10.19538 / j.ek2019030601
[35] 章如新. 变应性鼻炎的研究进展[J]. 山东大学耳鼻喉眼学报, 2016, 30(4):4. doi:10.6040/j.issn.1673-3770.0.2016.241 ZHANG Ruxin. Research progress on allergic rhinitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2016, 30(4):4. doi:10.6040/j.issn.1673-3770.0.2016.241
[36] Wheatley LM, Togias A. Allergic rhinitis[J]. N Engl J Med, 2015, 372(5): 456-463. doi:10.1056/nejmcp1412282
[37] Seidman MD, Gurgel RK, Lin SY, et al. Clinical practice guideline: Allergic rhinitis[J]. Otolaryngol Head Neck Surg, 2015, 152(1): 1-43. doi:10.1177/0194599814561600
[38] Roberts G, Xatzipsalti M, Borrego LM, et al. Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology[J]. Allergy, 2013, 68(9): 1102-1116. doi:10.1111/all.12235
[39] Zhang YM, Wei P, Chen BB, et al. Intranasal fluticasone furoate in pediatric allergic rhinitis: randomized controlled study[J]. Pediatr Res, 2021, 89(7): 1832-1839. doi:10.1038/s41390-020-01180-0
[40] Skoner DP, Gentile D, Angelini B, et al. The effects of intranasal triamcinolone acetonide and intranasal fluticasone propionate on short-term bone growth and HPA axis in children with allergic rhinitis[J]. Ann Allergy Asthma Immunol, 2003, 90(1): 56-62. doi:10.1016/S1081-1206(10)63615-0
[41] Galant SP, Melamed IR, Nayak AS, et al. Lack of effect of fluticasone propionate aqueous nasal spray on the hypothalamic-pituitary-adrenal axis in 2- and 3-year-old patients[J]. Pediatrics, 2003, 112(1): 96-100. doi:10.1542/peds.112.1.96
[42] 邱昕, 王洪田. 儿童鼻炎意见书: 欧洲变态反应与临床免疫学会推荐[J]. 国际耳鼻咽喉头颈外科杂志, 2015, 39(2): 116-121. doi:10.3760/cma.j.issn.1673-4106.2015.02.015 QIU Xin, WANG Hongtian. Opinion on children’s rhinitis: recommended by European Society of Allergy and Clinical Immunology[J]. International Journal of Otolaryngology-Head and Neck Surgery, 2015, 39(2): 116-121. doi:10.3760/cma.j.issn.1673-4106.2015.02.015
[43] 李华斌, 赖玉婷. 慢性鼻-鼻窦炎的发病机制及诊疗进展[J]. 山东大学耳鼻喉眼学报, 2018(3): 6. doi:10.6040/j.issn.1673-3770.1.2018.004 LIi Huabin, LAI Yuting. The pathogenesis and diagnosis and treatment progress of chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018(3): 6. doi: 10.6040/j.issn.1673-37770.1.2018.004
[44] Lou HF, Wang CS, Zhang L. Endotype-driven precision medicine in chronic rhinosinusitis[J]. Expert Rev Clin Immunol, 2019, 15(11): 1171-1183. doi:10.1080/1744666X.2020.1679626
[45] Farzal Z, Basu S, Burke A, et al. Comparative study of simulated nebulized and spray particle deposition in chronic rhinosinusitis patients[J]. Int Forum Allergy Rhinol, 2019, 9(7): 746-758. doi:10.1002/alr.22324
[46] Wang CS, Lou HF, Wang XD, et al. Effect of budesonide transnasal nebulization in patients with eosinophilic chronic rhinosinusitis with nasal polyps[J]. J Allergy Clin Immunol, 2015, 135(4): 922-929. doi:10.1016/j.jaci.2014.10.018
[47] Zhang YY, Lou HF, Wang Y, et al. Comparison of corticosteroids by 3 approaches to the treatment of chronic rhinosinusitis with nasal polyps[J]. Allergy Asthma Immunol Res, 2019, 11(4): 482-497. doi:10.4168/aair.2019.11.4.482
[48] Sindwani R, Han JK, Soteres DF, et al. NAVIGATE I: randomized, placebo-controlled, double-blind trial of the exhalation delivery system with fluticasone for chronic rhinosinusitis with nasal polyps[J]. Am J Rhinol Allergy, 2019, 33(1): 69-82. doi:10.1177/1945892418810281
[49] Garbe E, Suissa S. Inhaled corticosteroids and the risk of cataracts[J]. N Engl J Med, 1997, 337(21): 1555. doi:10.1056/NEJM199711203372115
[50] 徐文, 董频, 谷庆隆, 等. 雾化吸入在咽喉科疾病药物治疗中应用专家共识[J]. 中国耳鼻咽喉头颈外科, 2019, 26(5): 231-238. doi:10.16066/j.1672-7002.2019.05.001 XU Wen, DONG Pin, GU Qinglong, et al. Expert consensus on the application of atomized inhalation in drug treatment of throat diseases[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2019, 26(5): 231-238. doi:10.16066/j.1672-7002.2019.05.001
[51] Macias-Valle L, Psaltis AJ. A scholarly review of the safety and efficacy of intranasal corticosteroids preparations in the treatment of chronic rhinosinusitis[J]. Ear Nose Throat J, 2021, 100(5): 295-301. doi:10.1177/0145561320967727
[52] Feng X, Li G, Qu ZY, et al. Comparative analysis of upper airway volume with lateral cephalograms and cone-beam computed tomography[J]. Am J Orthod Dentofacial Orthop, 2015, 147(2): 197-204. doi:10.1016/j.ajodo.2014.10.025
[53] Pereira L, Monyror J, Almeida FT, et al. Prevalence of adenoid hypertrophy: a systematic review and meta-analysis[J]. Sleep Med Rev, 2018, 38: 101-112. doi:10.1016/j.smrv.2017.06.001
[54] Ahmad Z, Krüger K, Lautermann J, et al. Adenoid hypertrophy-?diagnosis and treatment: the new S2k guideline[J]. HNO, 2023, 71(1): 67-72. doi:10.1007/s00106-023-01299-6
[55] Chohan A, Lal A, Chohan K, et al. Systematic review and meta-analysis of randomized controlled trials on the role of mometasone in adenoid hypertrophy in children[J]. Int J Pediatr Otorhinolaryngol, 2015, 79(10): 1599-1608. doi:10.1016/j.ijporl.2015.07.009
[56] Zhang LJ, Mendoza-Sassi RA, César JA, et al. Intranasal corticosteroids for nasal airway obstruction in children with moderate to severe adenoidal hypertrophy[J]. Cochrane Database Syst Rev, 2008, 2008(3): CD006286. doi:10.1002/14651858.CD006286.pub2
[57] Bhargava R, Chakravarti A. A double-blind randomized placebo-controlled trial of topical intranasal mometasone furoate nasal spray in children of adenoidal hypertrophy with otitis media with effusion[J]. Am J Otolaryngol, 2014, 35(6): 766-770. doi:10.1016/j.amjoto.2014.06.006
[58] 高进良, 年婉清, 李烁. 鼻内镜手术联合鼻用糖皮质激素治疗腺样体肥大性小儿鼾症49例[J].山东大学耳鼻喉眼学报, 2018, 32(2): 38-42. doi:10.6040/j.issn.1673-3770.0.2017.404 GAO Jinliang, NIAN Wanqing, LI Shuo. Nasal endoscopic surgery combined with nasal corticosteroids for the treatment of 49 cases of adenoid hypertrophic snoring in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(2): 38-42. doi: 10.6040/j.issn. 1673-3770.0.2017.404
[59] 蔺林, 戴飞. 您对鼻用激素的顾虑都在这里[J]. 中华临床免疫和变态反应杂志, 2021, 15(2): 234-235. doi:10.3969/j.issn.1673-8705.2021.02.023 LIN Lin, DAI Fei. Your concerns about nasal hormones are all here[J]. Chinese Journal of Allergy and Clinical Immunology, 2021, 15(2): 234-235. doi:10.3969/j.issn.1673-8705.2021.02.023
[60] 中国医师协会变态反应医师分会, 中国医师协会儿科医师分会耳鼻咽喉专业委员会, 中国人体健康科技促进会儿童变态反应分会. 儿童过敏性鼻炎阶梯治疗中国专家共识[J]. 中华预防医学杂志, 2022, 56(9): 1182-1189. doi:10.3760/cma.j.cn112150-20220613-00602 Allergy Branch of Chinese Medical Doctor Association, Otolaryngology Group, Society of Pediatrics, Chinese Medical Doctor Association, and Child Allergy Professional Committee, China Association for Promotion of Health Science and Technology. Chinese expert consensus on stepwise treatment of pediatric allergic rhinitis[J]. Chinese Journal of Preventive Medicine, 2022, 56(9): 1182-1189. doi:10.3760/cma.j.cn112150-20220613-00602
[61] Baena-Cagnani CE. Safety and tolerability of treatments for allergic rhinitis in children[J]. Drug Saf, 2004, 27(12): 883-898. doi:10.2165/00002018-200427120-00005
[62] Sizonenko PC. Effects of inhaled or nasal glucocorticoids on adrenal function and growth[J]. J Pediatr Endocrinol Metab, 2002, 15(1): 5-26. doi:10.1515/jpem.2002.15.1.5
[63] Manji J, Singh G, Okpaleke C, et al. Safety of long-term intranasal budesonide delivered via the mucosal atomization device for chronic rhinosinusitis[J]. Int Forum Allergy Rhinol, 2017, 7(5): 488-493. doi:10.1002/alr.21910
[64] Schenkel EJ, Skoner DP, Bronsky EA, et al. Absence of growth retardation in children with perennial allergic rhinitis after one year of treatment with mometasone furoate aqueous nasal spray[J]. Pediatrics, 2000, 105(2): E22. doi:10.1542/peds.105.2.e22
[65] Gradman J, Caldwell MF, Wolthers OD. A 2-week, crossover study to investigate the effect of fluticasone furoate nasal spray on short-term growth in children with allergic rhinitis[J]. Clin Ther, 2007, 29(8): 1738-1747. doi:10.1016/j.clinthera.2007.08.017
[66] Ratner P, Darken P, Wingertzahn M, et al. Ciclesonide and beclomethasone dipropionate coadministration: effect on cortisol in perennial allergic rhinitis[J]. J Asthma, 2007, 44(8): 629-633. doi:10.1080/02770900701554359
[67] Skoner DP, Rachelefsky GS, Meltzer EO, et al. Detection of growth suppression in children during treatment with intranasal beclomethasone dipropionate[J]. Pediatrics, 2000, 105(2): 23. doi:10.1542/peds.105.2.e23
[68] Lee LA, Sterling R, Máspero J, et al. Growth velocity reduced with once-daily fluticasone furoate nasal spray in prepubescent children with perennial allergic rhinitis[J]. J Allergy Clin Immunol Pract, 2014, 2(4): 421-427. doi:10.1016/j.jaip.2014.04.008
[69] LaForce C, Journeay GE, Miller SD, et al. Ocular safety of fluticasone furoate nasal spray in patients with perennial allergic rhinitis: a 2-year study[J]. Ann Allergy Asthma Immunol, 2013, 111(1): 45-50. doi:10.1016/j.anai.2013.04.013
[70] Foisy MM, Yakiwchuk EM, Chiu I, et al. Adrenal suppression and Cushing's syndrome secondary to an interaction between ritonavir and fluticasone: a review of the literature[J]. HIV Med, 2008, 9(6): 389-396. doi:10.1111/j.1468-1293.2008.00579.x
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