山东大学耳鼻喉眼学报 ›› 2013, Vol. 27 ›› Issue (3): 10-12.doi: 10.6040/j.issn.1673-3770.0.2013.082

• 睡眠呼吸障碍性疾病 • 上一篇    下一篇

持续正压通气联合卡托普利、硝苯地平治疗重度阻塞性睡眠呼吸暂停低通气综合征合并高血压疗效观察

杨嵘,宗涛,孙亚男,陆金发   

  1. 青岛市城阳区人民医院耳鼻咽喉科,山东  青岛  266109
  • 收稿日期:2013-03-15 发布日期:2013-06-16
  • 作者简介:杨嵘。Email: jhtyr@sina.com

Clinical observation of continuous positive airway pressure  combined with captopril and nifedipine in the treatment of patients with severe OSAHS accompanied with hypertension

YANG Rong, ZONG Tao, SUN Ya-nan, LU Jin-fa   

  1. Department of Otolaryngology, Qingdao Chenyang People’s Hospital, Qingdao 266109, Shandong, China
  • Received:2013-03-15 Published:2013-06-16

摘要:

目的   观察持续正压通气(CPAP)联合卡托普利、硝苯地平对重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者高血压的影响。方法   选取重度OSAHS合并高血压患者66例,随机分为对照组及CPAP治疗组各33例。对照组患者予以卡托普利与硝苯地平药物治疗8周,CPAP治疗组患者在卡托普利与硝苯地平治疗的基础上加用CPAP治疗4周。两组分别于治疗前和治疗后同时测量22:00,2:00,6:00的收缩压和舒张压。结果   两组患者在22:00,2:00时间点收缩压与舒张压降至140/90的有效率无明显差异(P>0.1,P>0.1)。 对照组分别为(78.8%,63.6%)治疗组分别为(75.6%,60.6%);在6:00时治疗组的有效率(75.6%)高于对照组的有效率(51.5%),差异有统计学意义(0.025

关键词: 阻塞性睡眠呼吸暂停低通气综合征, 卡托普利;硝苯地平;临床观察, 持续气道正压通气, 高血压

Abstract:

Objective To investigate the effect of continuous positive airway pressure (CPAP) combined with captopril and nifedipine on severe obstructive sleep apnea hypopnea syndrome (OSAHS) patients with hypertension. Methods Sixty-six patients with severe OSAHS accompanied with hypertension were randomly divided into control group and CPAP group. In control group, the patients underwent captopril and nifedipine treatment for 8 weeks, while in CPAP group, extra CPAP treatment was applied concurrently for 4 weeks. Systolic and diastolic blood pressures were measured at 22:00, 2:00, 6:00 respectively. Effective rate and blood pressure changes before and after the treatment between the two groups were compared. Results The effective rates in both groups showed no significant differences at 22:00 (Ctrl 78.8%; CPAP 75.6%) and 2:00 (Ctrl 63.6%; CPAP 60.6%) (P>0.1, P>0.1). However, effective rate in CPAP group was significantly higher (75.6%) than that of control group (51.5%) at 6:00 (0.025

Key words: Hypertension, Nifedipine, Obstructive sleep apnea hypopnea syndrome, Captopril, Clinical observation, Continuous positive airway pressure

中图分类号: 

  • R766.7
[1] 陈璇,韩莉,范传峰,栗映梅,刘建,舒相纹,王玉. 高血压视网膜病变患者血浆内皮素-1的表达及意义[J]. 山东大学耳鼻喉眼学报, 2016, 30(6): 78-80.
[2] 于青青,唐隽,王跃建. 建立扁桃体腺样体不同手术方式对儿童阻塞性睡眠呼吸暂停低通气综合征疗效的系统评价体系[J]. 山东大学耳鼻喉眼学报, 2016, 30(5): 42-48.
[3] 高天喜,夏翠,闫静,侯瑾,康全清,王正辉,任晓勇. 间歇低氧模型大鼠肝脏组织中IGF-1、IGFBP-3的表达及分析[J]. 山东大学耳鼻喉眼学报, 2016, 30(5): 38-41.
[4] 王玉芝, 吕凌燕, 曲喆, 王兴杰, 周宣岩. 重度OSAHS并高血压患者行悬雍垂腭咽成形术前后血压变化分析[J]. 山东大学耳鼻喉眼学报, 2014, 28(5): 7-9.
[5] 李景慧, 吴红敏. 鼻腔扩容联合改良悬雍垂腭咽成形术对OSAHS患者血压的影响[J]. 山东大学耳鼻喉眼学报, 2014, 28(4): 16-19.
[6] 慕超,王岩,李延忠. 阻塞性睡眠呼吸暂停低通气综合征合并高血压动物模型的建立[J]. 山东大学耳鼻喉眼学报, 2014, 28(2): 1-3.
[7] 梁送民1,郭永伟2综述,赵霞1审校. 便携式睡眠监测仪对阻塞性睡眠呼吸暂停综合征的诊断价值[J]. 山东大学耳鼻喉眼学报, 2014, 28(2): 22-25.
[8] 罗伟,王旭平,陈震宇,张佳,吴麟,何飞,王佩杰,王干,郝虹. 羟甲唑啉鼻喷剂改善伴鼻阻塞OSAHS患者行nCPAP顺应性[J]. 山东大学耳鼻喉眼学报, 2014, 28(2): 26-28.
[9] 夏春鹏1,林燕辉2,李岩1,李克义1,张彬2. 口腔矫治器治疗对OSAHS患者焦虑抑郁及心理状态影响的研究[J]. 山东大学耳鼻喉眼学报, 2014, 28(2): 29-32.
[10] 罗惠秀,范春涛,邓延华. 阻塞性睡眠呼吸暂停低通气综合征患儿扁桃体腺样体切除术临床疗效分析[J]. 山东大学耳鼻喉眼学报, 2013, 27(4): 17-20.
[11] 谭杰,杨建国,王德生,刘健治,胡晓华,黄建民. 鼻腔扩容术治疗OSAHS疗效分析[J]. 山东大学耳鼻喉眼学报, 2012, 26(6): 10-12.
[12] 胡海林,朱鸿,施彩虹. 首诊于眼科的肾性高血压性视网膜病变1例[J]. 山东大学耳鼻喉眼学报, 2012, 26(4): 93-94.
[13] 王菡侨1,解建强2. 阻塞性睡眠呼吸暂停综合征的高血压发生机制[J]. 山东大学耳鼻喉眼学报, 2010, 24(01): 13-.
[14] 许振跃 方铭达 洪斌 李兆生. 软腭、舌体低温等离子消融配合H-UPPP治疗重度OSAHS 30例分析[J]. 山东大学耳鼻喉眼学报, 2009, 23(4): 12-14.
[15] 战秀兰,袁克美,张艳芬 . 141例中年期阻塞性睡眠呼吸暂停低通气综合征合并高血压患者的睡眠监测分析[J]. 山东大学耳鼻喉眼学报, 2008, 22(2): 109-111 .
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!