山东大学耳鼻喉眼学报 ›› 2013, Vol. 27 ›› Issue (3): 10-12.doi: 10.6040/j.issn.1673-3770.0.2013.082

• 睡眠呼吸障碍性疾病 • 上一篇    下一篇

持续正压通气联合卡托普利、硝苯地平治疗重度阻塞性睡眠呼吸暂停低通气综合征合并高血压疗效观察

杨嵘,宗涛,孙亚男,陆金发   

  1. 青岛市城阳区人民医院耳鼻咽喉科,山东  青岛  266109
  • 收稿日期:2013-03-15 发布日期:2013-06-16
  • 作者简介:杨嵘。Email: jhtyr@sina.com

Clinical observation of continuous positive airway pressure  combined with captopril and nifedipine in the treatment of patients with severe OSAHS accompanied with hypertension

YANG Rong, ZONG Tao, SUN Ya-nan, LU Jin-fa   

  1. Department of Otolaryngology, Qingdao Chenyang People’s Hospital, Qingdao 266109, Shandong, China
  • Received:2013-03-15 Published:2013-06-16

摘要:

目的   观察持续正压通气(CPAP)联合卡托普利、硝苯地平对重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者高血压的影响。方法   选取重度OSAHS合并高血压患者66例,随机分为对照组及CPAP治疗组各33例。对照组患者予以卡托普利与硝苯地平药物治疗8周,CPAP治疗组患者在卡托普利与硝苯地平治疗的基础上加用CPAP治疗4周。两组分别于治疗前和治疗后同时测量22:00,2:00,6:00的收缩压和舒张压。结果   两组患者在22:00,2:00时间点收缩压与舒张压降至140/90的有效率无明显差异(P>0.1,P>0.1)。 对照组分别为(78.8%,63.6%)治疗组分别为(75.6%,60.6%);在6:00时治疗组的有效率(75.6%)高于对照组的有效率(51.5%),差异有统计学意义(0.025

关键词: 阻塞性睡眠呼吸暂停低通气综合征, 卡托普利;硝苯地平;临床观察, 持续气道正压通气, 高血压

Abstract:

Objective To investigate the effect of continuous positive airway pressure (CPAP) combined with captopril and nifedipine on severe obstructive sleep apnea hypopnea syndrome (OSAHS) patients with hypertension. Methods Sixty-six patients with severe OSAHS accompanied with hypertension were randomly divided into control group and CPAP group. In control group, the patients underwent captopril and nifedipine treatment for 8 weeks, while in CPAP group, extra CPAP treatment was applied concurrently for 4 weeks. Systolic and diastolic blood pressures were measured at 22:00, 2:00, 6:00 respectively. Effective rate and blood pressure changes before and after the treatment between the two groups were compared. Results The effective rates in both groups showed no significant differences at 22:00 (Ctrl 78.8%; CPAP 75.6%) and 2:00 (Ctrl 63.6%; CPAP 60.6%) (P>0.1, P>0.1). However, effective rate in CPAP group was significantly higher (75.6%) than that of control group (51.5%) at 6:00 (0.025

Key words: Hypertension, Nifedipine, Obstructive sleep apnea hypopnea syndrome, Captopril, Clinical observation, Continuous positive airway pressure

中图分类号: 

  • R766.7
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