山东大学耳鼻喉眼学报 ›› 2019, Vol. 33 ›› Issue (2): 26-30.doi: 10.6040/j.issn.1673-3770.1.2019.010

• 专家笔谈 • 上一篇    下一篇

鼻咽癌的综合治疗研究进展

陆海军*(),刘霁,丁晓   

  1. 青岛大学附属医院肿瘤放疗科,山东 青岛 266003
  • 收稿日期:2019-02-20 出版日期:2019-03-20 发布日期:2019-03-28
  • 通讯作者: 陆海军 E-mail:lhj82920608@163.com
  • 作者简介:陆海军,医学博士,硕士生导师,青岛大学附属医院肿瘤放疗科主任。主要学术任职:中国医师协会放射肿瘤治疗医师分会委员,中国抗癌协会肿瘤精准治疗专业委员会委员,中国抗癌协会肿瘤热疗专业委员会委员,山东省医学会肿瘤放疗专业委员会副主任委员,世界华人医师协会放疗专业委员会常务委员,中国脑胶质瘤协作组成员、胶东协作组组长,山东省医师协会肿瘤综合治疗委员会副主任委员,山东省医学会姑息医学分会青年委员会副主任委员。青岛市优秀青年医学专家。擅长鼻咽癌、肺癌、食管及胃肠道肿瘤、乳腺癌、妇科肿瘤和淋巴瘤等的精准放疗及综合治疗。发表论文50余篇,主编著作1部,参编5部,获省部级二等奖3项,三等奖4项,在研课题7项

Progress in the comprehensive treatment for nasopharyngeal carcinoma

Haijun LU*(),Ji LIU,Xiao DING   

  1. Department of Radiation Oncology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China
  • Received:2019-02-20 Online:2019-03-20 Published:2019-03-28
  • Contact: Haijun LU E-mail:lhj82920608@163.com

摘要:

鼻咽癌是一种特殊且好发的头颈部肿瘤,好发于我国华南尤其是两广地区。因其解剖学限制及放疗敏感性,放疗为其主要的治疗手段,但单纯放疗有一定的局限性,形成了以放疗为基础,配合手术治疗、化疗、靶向治疗等的综合治疗是中晚期鼻咽癌的标准治疗模式。

关键词: 鼻咽肿瘤, 外科手术, 放射治疗, 化学治疗, 靶向治疗

Abstract:

Nasopharyngeal carcinoma is a distinct type of head and neck cancer that is common in South China, especially Guangdong and Guangxi. Because of the anatomical limitations of nasopharyngeal carcinoma and its sensitivity to radiotherapy, radiotherapy is the main treatment, although radiotherapy has certain limitations. Therefore, treatment for nasopharyngeal carcinoma includes radiotherapy combined with surgical treatment, chemotherapy, targeted therapy, and other comprehensive treatments.

Key words: Nasopharyngeal neoplasms, Surgical procedures, operative, Radiotherapy, Chemotherapy, Targeted therapy

中图分类号: 

  • R739.6
1 Al-Sarraf M , LeBlanc M , Giri PG , et al. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase Ⅲ randomized Intergroup study 0099[J]. J Clin Oncol, 1998, 16 (4): 1310- 1317.
doi: 10.1200/JCO.1998.16.4.1310
2 Wee J , Tan EH , Tai BC , et al. Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union against cancer stage Ⅲ and Ⅳ nasopharyngeal cancer of the endemic variety[J]. J Clin Oncol, 2005, 23 (27): 6730- 6738.
doi: 10.1200/JCO.2005.16.790
3 Lee AW , Tung SY , Chua DT , et al. Randomized trial of radiotherapy plus concurrent-adjuvant chemotherapy vs radiotherapy alone for regionally advanced nasopharyngeal carcinoma[J]. J Natl Cancer Inst, 2010, 102 (15): 1188- 98.
doi: 10.1093/jnci/djq258
4 Bian ZM , Elner VM , Lukacs NW , et al. Glycated human serum albumin induces IL-8 and MCP-1 gene expression in human corneal keratocytes[J]. Curr Eye Res, 1998, 17 (1): 65- 72.
doi: 10.1076/ceyr.17.1.65.5253
5 Motzer RJ , Agarwal N , Beard C , et al. NCCN clinical practice guidelines in oncology: kidney cancer[J]. J Natl Compr Canc Netw, 2009, 4 (8): 350- 391.
6 Chan ATC, Gregoire V, Lefebvre JL, et al. Nasopharyngeal cancer: EHNS-ESMO-ESTRO clinical practice guidelines for diagnosis, treatment and follow-up[J]. Annals of Oncology, 2012, 23(suppl 7):vii83-vii85. doi:10.1093/annonc/mds266.
7 Lang JY , Gao L , Guo Y , et al. Comprehensive treatment of squamous cell cancer of head and neck: Chinese expert consensus 2013[J]. Future Oncol, 2014, 10 (9): 1635- 1648.
doi: 10.2217/fon.14.44
8 Chen L , Hu CS , Chen XZ , et al. Concurrent chemoradiotherapy plus adjuvant chemotherapy versus concurrent chemoradiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 3 multicentre randomised controlled trial[J]. Lancet Oncol, 2012, 13 (2): 163- 171.
doi: 10.1016/S1470-2045(11)70320-5
9 Tan TH , Soon YY , Cheo T , et al. Induction chemotherapy for locally advanced nasopharyngeal carcinoma treated with concurrent chemoradiation: A systematic review and meta-analysis[J]. Radiother Oncol, 2018, 129 (1): 10- 17.
doi: 10.1016/j.radonc.2018.02.027
10 Hui EP , Ma BB , Leung SF , et al. Randomized phase Ⅱ trial of concurrent cisplatin-radiotherapy with or without neoadjuvant docetaxel and cisplatin in advanced nasopharyngeal carcinoma[J]. J Clin Oncol, 2009, 27 (2): 242- 249.
doi: 10.1200/JCO.2008.18.1545
11 Chen YP , Wang ZX , Chen L , et al. A Bayesian network meta-analysis comparing concurrent chemoradiotherapy followed by adjuvant chemotherapy, concurrent chemoradiotherapy alone and radiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma[J]. Ann Oncol, 2015, 26 (1): 205- 211.
doi: 10.1093/annonc/mdu507
12 OuYang PY , Xie C , Mao YP , et al. Significant efficacies of neoadjuvant and adjuvant chemotherapy for nasopharyngeal carcinoma by meta-analysis of published literature-based randomized, controlled trials[J]. Ann Oncol, 2013, 24 (8): 2136- 2146.
doi: 10.1093/annonc/mdt146
13 Cao SM , Yang Q , Guo L , et al. Neoadjuvant chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: A phase Ⅲ multicentre randomised controlled trial[J]. Eur J Cancer, 2017, 75: 14- 23.
doi: 10.1016/j.ejca.2016.12.039
14 Du CR , Ying HM , Zhou JJ , et al. Experience with combination of docetaxel, cisplatin plus 5-fluorouracil chemotherapy, and intensity-modulated radiotherapy for locoregionally advanced nasopharyngeal carcinoma[J]. Int J Clin Oncol, 2013, 18 (3): 464- 471.
doi: 10.1007/s10147-012-0403-y
15 Kong L , Zhang YW , Hu CS , et al. Effects of induction docetaxel, platinum, and fluorouracil chemotherapy in patients with stage Ⅲ or IVA/B nasopharyngeal cancer treated with concurrent chemoradiation therapy: Final results of 2 parallel phase 2 clinical trials[J]. Cancer, 2017, 123 (12): 2258- 2267.
doi: 10.1002/cncr.30566
16 Sun Y , Li WF , Chen NY , et al. Induction chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: a phase 3, multicentre, randomised controlled trial[J]. Lancet Oncol, 2016, 17 (11): 1509- 1520.
doi: 10.1016/S1470-2045(16)30410-7
17 Wu MY , He XY , Hu CS . Intensity-modulated radiotherapy combined with sequential cisplatin and fluorouracil chemotherapy for locoregionally advanced nasopharyngeal carcinoma[J]. Medicine (Baltimore), 2018, 97 (50): e13361.
doi: 10.1097/MD.0000000000013361
18 Chen YP , Guo R , Liu N , et al. Efficacy of the additional neoadjuvant chemotherapy to concurrent chemoradiotherapy for patients with locoregionally advanced nasopharyngeal carcinoma: a bayesian network meta-analysis of randomized controlled trials[J]. J Cancer, 2015, 6 (9): 883- 892.
doi: 10.7150/jca.11814
19 Ooft ML , Braunius WW , Heus P , et al. Prognostic significance of the EGFR pathway in nasopharyngeal carcinoma: a systematic review and meta-analysis[J]. Biomark Med, 2015, 9 (10): 997- 1010.
doi: 10.2217/bmm.15.68
20 Huang JF , Yuan XP , Pang QF , et al. Radiosensitivity enhancement by combined treatment of nimotuzumab and celecoxib on nasopharyngeal carcinoma cells[J]. DDDT, 2018, 12: 2223- 2231.
doi: 10.2147/dddt.s163595
21 Huang Y , Qiu QH . Endoscopic surgery for early-stage nasopharyngeal carcinoma: a justified initial option[J]. Acta Otolaryngol, 2017, 137 (11): 1194- 1198.
doi: 10.1080/00016489.2017.1351041
22 Si YF, Lan GP, Deng ZX, et al. Influence of endoscopic sinus surgery on the quality of life of patients with early nasopharyngeal carcinoma and the analysis of prognosis-related factors[J]. Tumour Biol, 2017, 39(7):1010428317707435. doi:10.1177/1010428317707435.
23 Sun J , Huang ZY , Hu ZY , et al. Benefits of local tumor excision and pharyngectomy on the survival of nasopharyngeal carcinoma patients: a retrospective observational study based on SEER database[J]. J Transl Med, 2017, 15 (1): 116.
doi: 10.1186/s12967-017-1204-x
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