肠道菌群在阻塞性睡眠呼吸暂停相关认知功能障碍中的研究进展

doi:10.6040/j.issn.1673-3770.0.2022.233

摘要/Abstract

摘要： 阻塞性睡眠呼吸暂停(obstructive sleep apnea, OSA)是最常见的睡眠呼吸紊乱疾病,认知障碍是其严重的并发症之一。近几十年来,肠道菌群失衡在OSA相关认知障碍中的作用成为了研究热点,但具体关系及机制尚未明确。本文从肠道菌群及其代谢改变与继发的宿主的病理改变等方面,从慢性间歇性缺氧与睡眠片段化等角度,涉及饮食、环境因素等方面,介绍了肠道菌群失衡在OSA并发认知障碍中可能的机制,对持续正压通气传统治疗方式对于认知功能的改变和肠道菌群的影响也作出了相应的描述。系统地了解肠道菌群与认知相关的肠脑轴之间的关系,以期为伴有认知功能障碍的OSA患者提供多样的、个体化的诊疗策略。

关键词: 睡眠呼吸暂停, 阻塞性, 肠道菌群, 认知功能障碍, 肠脑轴

Abstract: Objective Obstructive sleep apnea(OSA)is the most common type of sleep-disordered breathing. Cognitive impairment is a serious complication of OSA. Over the past few decades, research on OSA-related cognitive impairment has focused on the involvement of intestinal flora imbalance. Although this area of study has become a research hotspot, the nature of the relationship between gut dysbiosis and OSA-related cognitive impairment as well as the mechanisms through which they interact are still not clearly understood. In this paper, discussion of intestinal microflora, metabolic changes, and secondary host pathological changes,both from the aspects of chronic intermittent hypoxia and sleep fragmentation, involving dietary habit and environmental factor and so on, which will provide a framework through which potential mechanisms of interaction between intestinal microflora imbalance and cognitive impairment secondary to OSA and also describe the effect of traditional continuous positive airway pressure treatment on cognitive function and gut microbiota. Systematic investigation and thorough understanding of this relationship between the microbiota and cognition-related gut-brain axis, is essential for not only proper diagnosis but also development of comprehensive treatment plans that can be tailored to individual patients with OSA and subsequent cognitive impairment.

Key words: Sleep apnea, Obstructive, Intestinal flora, Cognitive impairment, The-gut-brain axis

中图分类号:

R766.49

郭瑞祥,王岩. 肠道菌群在阻塞性睡眠呼吸暂停相关认知功能障碍中的研究进展[J]. 山东大学耳鼻喉眼学报, 2023, 37(6): 15-23.

GUO Ruixiang, WANG Yan. Recent advances in research on the association between intestinal flora and obstructive sleep apnea-related cognitive impairment[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(6): 15-23.

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