翼管神经切断术在难治性变应性鼻炎中远期临床疗效和安全性

doi:10.6040/j.issn.1673-3770.0.2024.407

摘要/Abstract

摘要： 目的评估翼管神经切断术治疗难治性变应性鼻炎(allergic rhinitic, AR)的远期临床疗效和安全性。方法纳入49例难治性AR患者。通过视觉模拟量表(visual analogue scale, VAS)评分记录翼管神经切断术前及术后1年患者鼻部症状(鼻痒、鼻塞、喷嚏、清涕)严重程度,以评价其临床疗效;采用术后不良反应的记录评价手术安全性;采用患者术前各项临床指标与疗效的相关性分析,探索可能影响疗效的临床指标;应用SPSS 22.0软件进行统计学分析。结果翼管神经切断术后1年,患者总体症状和鼻部各症状的VAS评分均显著降低,差异有统计学意义(P<0.05),治疗有效率为85.71%(42/49);术后不良反应发生率10%(5/49);对患者术前各项临床指标与术后疗效相关性分析,差异均无统计学意义(P>0.05)。结论翼管神经切断术对难治性AR具有确切远期临床疗效和良好安全性,其疗效与术前患者各临床特征均无相关性。

关键词: 翼管神经切断术, 变应性鼻炎, 难治性, 临床疗效, 安全性

Abstract: Objective To evaluate the long-term clinical efficacy, safety of vidian neurectomy in the treatment of refractory allergic rhinitis(AR). Methods A total of 49 patients with refractory AR were enrolled in the study. The visual analogue scale(VAS)score was used to assess nasal symptoms-including nasal itching, nasal congestion, sneezing and rhinorrhea-before surgery and 1 years postoperatively. Symptom improvement was compared pre- and post-treatment. Postoperative adverse events were recorded to assess the safety of the procedure. The SPSS 22.0 software was used for statistical analysis. Results The VAS scores of both overall and individual nasal symptoms were significantly reduced after vidian neurectomy. The overall effective rate was 85.71%(42/49), showing a statistically significant improvement compared to preoperative scores(P<0.05). The incidence of postoperative adverse reactions was 10%(5/49). Further analysis found no statistically significant correlation between preoperative clinical indicators(both subjective and objective)and postoperative outcomes(P>0.05). Conclusion Vidian neurectomy provides substantial clinical benefit and a favorable safety profile for refractory AR. Furthermore, the effectiveness of the procedure does not appear to be influenced by patients' preoperative subjective symptoms or objective indicators.

Key words: Vidian neurectomy, Allergic rhinitis, Refractory, Efficacy evaluation, Safety

中图分类号:

R765.21

刘怡君,谷悦,官大宇,杨玉成,沈暘. 翼管神经切断术在难治性变应性鼻炎中远期临床疗效和安全性[J]. 山东大学耳鼻喉眼学报, 2025, 39(5): 42-48.

LIU Yijun, GU Yue, GUAN Dayu, YANG Yucheng, SHEN Yang. The long-term clinical efficacy and safety of vidian neurectomy in refractory allergic rhinitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 42-48.

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