细胞焦亡在老年退行性疾病中的研究进展

doi:10.6040/j.issn.1673-3770.0.2022.090

Abstract

Abstract: Pyroptosis is a process that mainly induces the activation of the inflammatory cysteine-aspartate-specific protease family through the inflammasome and subsequently cleaves the gasdermin family of pyroptotic proteins. This eventually leads to the rupture of cell membranes and release of cell contents, causing an intense novel programmed cell death mode of inflammatory responses. Currently reported pyroptosis pathways mainly include the caspase-1-dependent classical, caspase-11-dependent non-classical, caspase-3-dependent gasdermin E, and caspase-8-dependent gasdermin D pyroptosis pathways. In these multiple pyroptotic signaling pathways, the inflammasome and pyroptotic protein, gasdermins, play important roles as pioneers and executors. In recent years, with the advent of the aging era, research on pyroptosis in senile degenerative diseases has attracted attention. This article mainly reviews the main mechanism of pyroptosis and its research progress in senile degenerative diseases such as presbycusis, age-related macular degeneration, and Alzheimer's disease.

Key words: Pyroptosis, Inflammasome, Gasdermin family, Presbycusis, Age-related macular degeneration, Alzheimer's disease

CLC Number:

R764.43+6

ZHOU Jiamin, SONG Yuwan, SUN Yan. Research progress of pyroptosis in senile degenerative diseases[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(4): 172-180.

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