Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (4): 166-171.doi: 10.6040/j.issn.1673-3770.0.2022.197

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Research progress of pyroptosis in chronic airway inflammatory disease

YUAN Yue, FU Shengyao, JIANG Yan, CHEN Min   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China
  • Published:2023-07-27

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Abstract: Pyroptosis is a form of programmed cell death that involves the activation of canonical(caspase-1-dependent)and noncanonical(caspase-4/5/11-dependent)pathways, which are normally triggered by inflammatory factors. Pyroptosis has become a trending discussion topic due to its role in promoting chronic inflammatory airway diseases, as revealed by previous studies. This paper reviews the latest research advances in pyroptosis, with respect to allergic rhinitis, chronic sinusitis, asthma, and chronic obstructive pulmonary diseases, with the aim of catalyzing new ideas for improved treatments.

Key words: Pyroptosis, Allergic rhinitis, Chronic sinusitis, Asthma, Chronic obstructive pulmonary disease

CLC Number: 

  • R76
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