肠道菌群在阻塞性睡眠呼吸暂停相关认知功能障碍中的研究进展

doi:10.6040/j.issn.1673-3770.0.2022.233

Abstract

Abstract: Objective Obstructive sleep apnea(OSA)is the most common type of sleep-disordered breathing. Cognitive impairment is a serious complication of OSA. Over the past few decades, research on OSA-related cognitive impairment has focused on the involvement of intestinal flora imbalance. Although this area of study has become a research hotspot, the nature of the relationship between gut dysbiosis and OSA-related cognitive impairment as well as the mechanisms through which they interact are still not clearly understood. In this paper, discussion of intestinal microflora, metabolic changes, and secondary host pathological changes,both from the aspects of chronic intermittent hypoxia and sleep fragmentation, involving dietary habit and environmental factor and so on, which will provide a framework through which potential mechanisms of interaction between intestinal microflora imbalance and cognitive impairment secondary to OSA and also describe the effect of traditional continuous positive airway pressure treatment on cognitive function and gut microbiota. Systematic investigation and thorough understanding of this relationship between the microbiota and cognition-related gut-brain axis, is essential for not only proper diagnosis but also development of comprehensive treatment plans that can be tailored to individual patients with OSA and subsequent cognitive impairment.

Key words: Sleep apnea, Obstructive, Intestinal flora, Cognitive impairment, The-gut-brain axis

CLC Number:

R766.49

GUO Ruixiang, WANG Yan. Recent advances in research on the association between intestinal flora and obstructive sleep apnea-related cognitive impairment[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(6): 15-23.

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Recent advances in research on the association between intestinal flora and obstructive sleep apnea-related cognitive impairment

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