Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (1): 122-127.doi: 10.6040/j.issn.1673-3770.0.2022.515

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Advances in severe acute respiratory syndrome coronavirus 2 study about ophthalmology

DING Xiaomin1,2, CUI Yan1   

  1. 1. Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China2. The First Clinical College of Shandong University, Jinan 250012, Shandong, China
  • Published:2024-01-12

Abstract: Corona virus disease 2019(COVID-19)is an acute infectious pneumonia caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). Previous reports have suggested that patients with COVID-19 may also exhibit ocular symptoms, and some ophthalmic adverse events have been reported after COVID-19 vaccination. Based on the recent literature and existing studies, this study aims to discuss the possibility of ophthalmic infections due to SARS-CoV-2, the ocular signs, treatments and possible ocular adverse events after COVID-19 vaccination, and provide references to the ophthalmologists for prevention and control.

Key words: Corona virus disease 2019, Conjunctivitis, Retinal vasculopathy, Choroid, Angle-closure glaucoma

CLC Number: 

  • R77
[1] Chen NS, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study[J]. Lancet, 2020, 395(10223): 507-513. doi:10.1016/S0140-6736(20)30211-7
[2] Lu HZ, Stratton CW, Tang YW. Outbreak of pneumonia of unknown etiology in Wuhan, China: the mystery and the miracle[J]. J Med Virol, 2020, 92(4): 401-402. doi:10.1002/jmv.25678
[3] Wu P, Duan F, Luo CH, et al. Characteristics of ocular findings of patients with coronavirus disease 2019(COVID-19)in Hubei Province, China[J]. JAMA Ophthalmol, 2020, 138(5): 575-578. doi:10.1001/jamaophthalmol.2020.1291
[4] Ocansey S, Abu EK, Abraham CH, et al. Ocular symptoms of SARS-CoV-2: indication of possible ocular transmission or viral shedding[J]. Ocul Immunol Inflamm, 2020, 28(8): 1269-1279. doi:10.1080/09273948.2020.1799035
[5] Xia JH, Tong JP, Liu MY, et al. Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection[J]. J Med Virol, 2020, 92(6): 589-594. doi:10.1002/jmv.25725
[6] Belser JA, Rota PA, Tumpey TM. Ocular tropism of respiratory viruses[J]. Microbiol Mol Biol Rev, 2013, 77(1): 144-156. doi:10.1128/MMBR.00058-12
[7] Seah I, Agrawal R. Can the coronavirus disease 2019(COVID-19)affect the eyes? A review of coronaviruses and ocular implications in humans and animals[J]. Ocul Immunol Inflamm, 2020, 28(3): 391-395. doi:10.1080/09273948.2020.1738501
[8] 季樱红, 孙杨, 卢奕. 新型冠状病毒的眼睛侵入途径与眼科防护重点[J]. 中国眼耳鼻喉科杂志, 2020, 20(3): 156-161.doi: 10.14166/j.issn.1671-2420.2020.03.003 JI Yinghong, SUN Yang, LU Yi. Eye invasion route of 2019 novel corona virus and the emphasis of ophthalmic protection[J]. Chinese Journal of Ophthalmology and otorhinolaryngology, 2020, 20(3): 156-161.doi: 10.14166/j.issn.1671-2420.2020.03.003
[9] Imai Y, Kuba K, Ohto-Nakanishi T, et al. Angiotensin-converting enzyme 2(ACE2)in disease pathogenesis[J]. Circ J, 2010, 74(3): 405-410. doi:10.1253/circj.cj-10-0045
[10] Li W, Moore MJ, Vasilieva N, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus[J]. Nature, 2003, 426(6965): 450-454. doi: 10.1038/nature02145
[11] Deng W, Bao LL, Gao H, et al. Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in rhesus macaques[J]. Nat Commun, 2020, 11(1): 4400. doi:10.1038/s41467-020-18149-6
[12] Hui KPY, Cheung MC, Perera RAPM, et al. Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures[J]. Lancet Respir Med, 2020, 8(7): 687-695. doi:10.1016/S2213-2600(20)30193-4
[13] Menni C, Valdes AM, Polidori L, et al. Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study[J]. Lancet, 2022, 399(10335): 1618-1624. doi:10.1016/S0140-6736(22)00327-0
[14] Guan WJ, Zhong NS. Clinical Characteristics of Covid-19 in China. Reply[J]. N Engl J Med, 2020, 382(19): 1861-1862. doi:10.1056/NEJMc2005203
[15] Wu P, Liang L, Chen CB, et al. A child confirmed COVID-19 with only symptoms of conjunctivitis and eyelid dermatitis[J]. Graefes Arch Clin Exp Ophthalmol, 2020, 258(7): 1565-1566. doi:10.1007/s00417-020-04708-6
[16] Navel V, Chiambaretta F, Dutheil F. Haemorrhagic conjunctivitis with pseudomembranous related to SARS-CoV-2[J]. Am J Ophthalmol Case Rep, 2020, 19: 100735. doi:10.1016/j.ajoc.2020.100735
[17] Méndez Mangana C, Barraquer Kargacin A, Barraquer RI. Episcleritis as an ocular manifestation in a patient with COVID-19[J]. Acta Ophthalmol, 2020, 98(8): e1056-e1057. doi:10.1111/aos.14484
[18] François J, Collery AS, Hayek G, et al. Coronavirus disease 2019-associated ocular neuropathy with panuveitis: a case report[J]. JAMA Ophthalmol, 2021, 139(2): 247-249. doi:10.1001/jamaophthalmol.2020.5695
[19] Providência J, Fonseca C, Henriques F, et al. Serpiginous choroiditis presenting after SARS-CoV-2 infection: a new immunological trigger?[J]. Eur J Ophthalmol, 2022, 32(1): NP97-NP101. doi:10.1177/1120672120977817
[20] Casagrande M, Fitzek A, Püschel K, et al. Detection of SARS-CoV-2 in human retinal biopsies of deceased COVID-19 patients[J]. Ocul Immunol Inflamm, 2020, 28(5): 721-725. doi:10.1080/09273948.2020.1770301
[21] de Figueiredo CS, Raony í, Giestal-de-Araujo E. SARS-CoV-2 targeting the retina: host-virus interaction and possible mechanisms of viral tropism[J]. Ocul Immunol Inflamm, 2020, 28(8): 1301-1304. doi:10.1080/09273948.2020.1799037
[22] Varga Z, Flammer AJ, Steiger P, et al. Endothelial cell infection and endotheliitis in COVID-19[J]. Lancet, 2020, 395(10234): 1417-1418. doi:10.1016/S0140-6736(20)30937-5
[23] Marinho PM, Marcos AAA, Romano AC, et al. Retinal findings in patients with COVID-19[J]. Lancet, 2020, 395(10237): 1610. doi:10.1016/S0140-6736(20)31014-X
[24] Invernizzi A, Torre A, Parrulli S, et al. Retinal findings in patients with COVID-19: results from the SERPICO-19 study[J]. EClinicalMedicine, 2020, 27: 100550. doi:10.1016/j.eclinm.2020.100550
[25] Sheth JU, Narayanan R, Goyal J, et al. Retinal vein occlusion in COVID-19: a novel entity[J]. Indian J Ophthalmol, 2020, 68(10): 2291-2293. doi:10.4103/ijo.IJO_2380_20
[26] Ortiz-Seller A, Martínez Costa L, Hernández-Pons A, et al. Ophthalmic and neuro-ophthalmic manifestations of coronavirus disease 2019(COVID-19)[J]. Ocul Immunol Inflamm, 2020, 28(8): 1285-1289. doi:10.1080/09273948.2020.1817497
[27] Benito-Pascual B, Gegúndez JA, Díaz-Valle D, et al. Panuveitis and optic neuritis as a possible initial presentation of the novel coronavirus disease 2019(COVID-19)[J]. Ocul Immunol Inflamm, 2020, 28(6): 922-925. doi:10.1080/09273948.2020.1792512
[28] 中华预防医学会公共卫生眼科学分会. 中国新型冠状病毒眼病防控专家共识(2022年)[J]. 中华眼科杂志, 2022, 58(3): 176-181. doi: 10.3760/cma.j.cn112142-20211124-00561
[29] Luís ME, Hipólito-Fernandes D, Mota C, et al. A review of neuro-ophthalmological manifestations of human coronavirus infection[J]. Eye Brain, 2020, 12: 129-137. doi:10.2147/EB.S268828
[30] Tisdale AK, Chwalisz BK. Neuro-ophthalmic manifestations of coronavirus disease 19[J]. Curr Opin Ophthalmol, 2020, 31(6): 489-494. doi:10.1097/ICU.0000000000000707
[31] Ordás CM, Villacieros-álvarez J, Pastor-Vivas AI, et al. Concurrent tonic pupil and trochlear nerve palsy in COVID-19[J]. J Neurovirol, 2020, 26(6): 970-972. doi:10.1007/s13365-020-00909-1
[32] 胡明霞, 袁建明, 张彬, 等. 新型冠状病毒疫苗的研究进展[J]. 中国感染与化疗杂志, 2022, 22(4): 504-508. doi: 10.16718/j.1009-7708.2022.04.023 HU Mingxia, YUAN Jianming, ZHANG Bin, et al. Research updates on SARS-CoV-2 vaccines[J]. Chinese Journal of Infection and Chemotherapy, 2022, 22(4): 504-508. doi: 10.16718/j.1009-7708.2022.04.023
[33] Haseeb AA, Solyman O, Abushanab MM, et al. Ocular complications following vaccination for COVID-19: a one-year retrospective[J]. Vaccines(Basel), 2022, 10(2): 342. doi:10.3390/vaccines10020342
[34] Sheng QL, Sun YN, Zhai RY, et al. Posner-Schlossman syndrome relapse following inactivated COVID-19 vaccination in China[J]. Front Public Health, 2022, 10: 1051378. doi:10.3389/fpubh.2022.1051378
[35] Fraunfelder FW, Suhler EB, Fraunfelder FT. Hepatitis B vaccine and uveitis: an emerging hypothesis suggested by review of 32 case reports[J]. Cutan Ocul Toxicol, 2010, 29(1): 26-29. doi:10.3109/15569520903427717
[36] Aguirre G, Carmichael L, Bistner S. Corneal endothelium in viral induced anterior uveitis. Ultrastructural changes following canine adenovirus type 1 infection[J]. Arch Ophthalmol, 1975, 93(3): 219-224. doi:10.1001/archopht.1975.01010020227012
[37] Rabinovitch T, Ben-Arie-Weintrob Y, Hareuveni-Blum T, et al. Uveitis after the bnt162b2 mrna vaccination against sars-cov-2 infection: a possible association[J]. Retina, 2021, 41(12): 2462-2471. doi:10.1097/IAE.0000000000003277
[38] Steinemann TL, Koffler BH, Jennings CD. Corneal allograft rejection following immunization[J]. Am J Ophthalmol, 1988, 106(5): 575-578. doi:10.1016/0002-9394(88)90588-0
[39] Abousy M, Bohm K, Prescott C, et al. Bilateral EK rejection after COVID-19 vaccine[J]. Eye Contact Lens, 2021, 47(11): 625-628. doi:10.1097/ICL.0000000000000840
[40] Bøhler AD, Strøm ME, Sandvig KU, et al. Acute macular neuroretinopathy following COVID-19 vaccination[J]. Eye(Lond), 2022, 36(3): 644-645. doi: 10.1038/s41433-021-01610-1
[41] Pichi F, Aljneibi S, Neri P, et al. Association of ocular adverse events with inactivated COVID-19 vaccination in patients in abu dhabi[J]. JAMA Ophthalmol, 2021, 139(10): 1131-1135. doi: 10.1001/jamaophthalmol.2021.3477
[42] Mambretti M, Huemer J, Torregrossa G, et al. Acute macular neuroretinopathy following coronavirus disease 2019 vaccination[J]. Ocul Immunol Inflamm, 2021, 29(4): 730-733. doi:10.1080/09273948.2021.1946567
[43] Elnahry AG, Al-Nawaflh MY, Gamal Eldin AA, et al. COVID-19 vaccine-associated optic neuropathy: a systematic review of 45 patients[J]. Vaccines(Basel), 2022, 10(10): 1758. doi:10.3390/vaccines10101758
[44] Eleiwa TK, Gaier ED, Haseeb A, et al. Adverse ocular events following COVID-19 vaccination[J]. Inflamm Res, 2021, 70(10/11/12): 1005-1009. doi:10.1007/s00011-021-01506-6
[45] Tsukii R, Kasuya Y, Makino S. Nonarteritic anterior ischemic optic neuropathy following COVID-19 vaccination: consequence or coincidence[J]. Case Rep Ophthalmol Med, 2021: 5126254. doi:10.1155/2021/5126254
[46] 陈博, 张宪, 孙旭芳. 新型冠状病毒防控中眼科医务人员的预防措施[J]. 国际眼科杂志, 2020, 20(3): 580-582. doi: 10.3980/j.issn.1672-5123.2020.3.41 CHEN Bo, ZHANG Xian, SUN Xufang. Precaution of SARS-CoV-2 infection in ophthalmology medical staff[J]. International Eye Science, 2020, 20(3): 580-582. doi: 10.3980/j.issn.1672-5123.2020.3.41
[47] Kampf G, Todt D, Pfaender S, et al. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents[J]. J Hosp Infect, 2020, 104(3): 246-251. doi:10.1016/j.jhin.2020.01.022
[48] Du H, Zhang M, Zhang H, et al. Practical experience on emergency ophthalmic surgery during the prevalence of COVID-19[J]. Albrecht Von Graefes Arch Fur Klinische Und Exp Ophthalmol, 2020, 258(8): 1831-1833. doi:10.1007/s00417-020-04692-x
[49] Yu AY, Tu RX, Shao X, et al. A comprehensive Chinese experience against SARS-CoV-2 in ophthalmology[J]. Eye Vis(Lond), 2020, 7: 19. doi:10.1186/s40662-020-00187-2
[50] Güemes-Villahoz N, Burgos-Blasco B, Vidal-Villegas B, et al. Novel insights into the transmission of SARS-CoV-2 through the ocular surface and its detection in tears and conjunctival secretions: a review[J]. Adv Ther, 2020, 37(10): 4086-4095. doi:10.1007/s12325-020-01442-7
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