Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2025, Vol. 39 ›› Issue (3): 162-167.doi: 10.6040/j.issn.1673-3770.0.2023.442

• Review • Previous Articles    

Study on the relationship between the effects of hyperlipidemia on retinal damage and choroid thickness

MAO Yiheng1,2, FENG Jie2, HE Runtian2   

  1. 1. Graduate School of Shandong First Medical University, Jinan 250117, Shandong, China2. Department of Ophthalmology, Jining First People's Hospital, Jining 272011, Shandong, China
  • Published:2025-06-04

PDF (PC)

67

Abstract: The patients with hypercholesterolemia and high and low-density lipoproteinemia comprise a high proportion of patients with fundus diseases. This has thus become an important risk factor in the occurrence and development of fundus diseases. The present study explored the effects of hypercholesterolemia and high- and low-density lipoproteins on choroidal thickness and the retinal photosensitive cell layer. These effects include promotion of the aggregation of inflammatory factors and vascular endothelial growth factor, as well as changes of choroidal thickness in fundus diseases such as macular degeneration, macular edema, and choroidal detachment. The law of change of choroidal thickness was summarized to provide a reference for early warning of the occurrence and development of these diseases.

Key words: Choroidal thickness, Hypercholesterolemia, High- and low-density lipoproteinemia, Inflammatory factor, Age-related macular degeneration, Macular cystoid edema

CLC Number: 

  • R54
[1] 毛莲, 黄伶智, 潘露, 等. 2009至2019年中国人群血脂研究热点分析[J]. 中国动脉硬化杂志, 2020, 28(7): 616-622. doi:10.3969/j.issn.1007-3949.2020.07.013 MAO Lian, HUANG Lingzhi, PAN Lu, et al. Hotspot analysis of blood lipid research in Chinese population from 2009 to 2019[J]. Chinese Journal of Arteriosclerosis, 2020, 28(7): 616-622. doi:10.3969/j.issn.1007-3949.2020.07.013
[2] Hou XH, Wang LM, Zhu DL, et al. Prevalence of diabetic retinopathy and vision-threatening diabetic retinopathy in adults with diabetes in China[J]. Nat Commun, 2023, 14: 4296. doi:10.1038/s41467-023-39864-w
[3] 李胜, 李春实, 纪莉莉, 等. 糖尿病性视网膜病变硬性渗出与血脂异常关系的研究[J]. 当代医学, 2018, 24(35): 75-77. doi:10.3969/j.issn.1009-4393.2018.35.030 LI Sheng, LI Chunshi, JI Lili, et al. A study on relationship between hard exudation and dyslipidemia in diabetic retinopathy[J]. Contemporary Medicine, 2018, 24(35): 75-77. doi:10.3969/j.issn.1009-4393.2018.35.030
[4] Lin CY, Huang YL, Hsia WP, et al. Correlation of choroidal thickness with age in healthy subjects: automatic detection and segmentation using a deep learning model[J]. Int Ophthalmol. 2022, 42(10):3061-3070. doi: 10.1007/s10792-022-02292-8
[5] 郭梦翔, 闫利锋, 周瑾, 等. 原发性视网膜色素变性患者血清脂蛋白与血流参数相关性研究[J]. 临床眼科杂志, 2017, 25(2): 97-99. doi:10.3969/j.issn.1006-8422.2017.02.001 GUO Mengxiang, YAN Lifeng, ZHOU Jin, et al. Correlation between serum lipoprotein and blood flow parameters in patients with primary retinal pigmentosa[J]. Journal of Clinical Ophthalmology, 2017, 25(2): 97-99. doi:10.3969/j.issn.1006-8422.2017.02.001
[6] Endo H, Kase S, Ito Y, et al. Relationship between choroidal structure and duration of diabetes[J]. Graefe's Arch Clin Exp Ophthalmol, 2019, 257(6): 1133-1140. doi:10.1007/s00417-019-04295-1
[7] Cackett P, Yeo I, Cheung CMG, et al. Relationship of smoking and cardiovascular risk factors with polypoidal choroidal vasculopathy and age-related macular degeneration in Chinese persons[J]. Ophthalmology, 2011, 118(5): 846-852. doi:10.1016/j.ophtha.2010.09.026
[8] Wang W, Liu S, Qiu ZH, et al. Choroidal thickness in diabetes and diabetic retinopathy: a swept source OCT study[J]. Invest Ophthalmol Vis Sci, 2020, 61(4): 29. doi:10.1167/iovs.61.4.29
[9] Kaderli A, Acar MA, Ünlü N, et al. The correlation of hyperopia and choroidal thickness, vessel diameter and area[J]. Int Ophthalmol, 2018, 38(2): 645-653. doi:10.1007/s10792-017-0509-3
[10] Kocamaz M, Karada g O, Onder SE. Comparison of choroidal thicknesses in patients with coronary artery disease and patients at risk of coronary artery disease[J]. Int Ophthalmol, 2021, 41(6): 2117-2124. doi:10.1007/s10792-021-01769-2
[11] Salazar JJ, Ramírez AI, de Hoz R, et al. Alterations in the choroid in hypercholesterolemic rabbits: reversibility after normalization of cholesterol levels[J]. Exp Eye Res., 2007, 84(3):412-22. doi: 10.1016/j.exer.2006.10.012
[12] Lee SSY, Lingham G, Alonso-Caneiro D, et al. Choroidal thickness in young adults and its association with visual acuity[J]. Am J Ophthalmol, 2020, 214: 40-51. doi:10.1016/j.ajo.2020.02.012
[13] 钱欣, 王继红, 褚婷, 等. 脉络膜厚度和血管密度与糖尿病视网膜病变严重程度的相关性[J]. 临床眼科志, 2023, 31(3): 211-214. doi: 10.3969/j.issn.1006-8422.2023.03.005 QIAN Xin, WANG Jihong, CHU Ting, et al. The correlation between choroidal thickness ascular density and the severity of diabetic retinopathy[J]. Journal of Clinical Ophthalmology, 2023, 31(3): 211-214. doi: 10.3969/j.issn.1006-8422.2023.03.005
[14] Mahmud M, Ahem A, Bastion ML C, et al. The relationship between choroidal and photoreceptor layer thickness with visual acuity in highly myopic eyes[J]. Front Cell Neurosci, 2022, 16: 800065. doi:10.3389/fncel.2022.800065
[15] Yin L, Zhang DL, Ren Q, et al. Prevalence and risk factors of diabetic retinopathy in diabetic patients: a community based cross-sectional study[J]. Medicine, 2020, 99(9): e19236. doi:10.1097/MD.0000000000019236
[16] Zhang XY, Wang KY, Zhu L, et al. Reverse cholesterol transport pathway and cholesterol efflux in diabetic retinopathy[J]. J Diabetes Res, 2021: 8746114. doi:10.1155/2021/8746114
[17] Busik JV. Lipid metabolism dysregulation in diabetic retinopathy[J]. J Lipid Res, 2021, 62: 100017. doi:10.1194/jlr.TR120000981
[18] Zhou Y, Wang CY, Shi K, et al. Relationship between dyslipidemia and diabetic retinopathy: a systematic review and meta-analysis[J]. Medicine, 2018, 97(36): e12283. doi:10.1097/MD.0000000000012283
[19] Nazih H, Bard JM. Cholesterol, oxysterols and LXRs in breast cancer pathophysiology[J]. Int J Mol Sci, 2020, 21(4): 1356. doi:10.3390/ijms21041356
[20] Xu HJ, Zhou S, Tang QL, et al. Cholesterol metabolism: new functions and therapeutic approaches in cancer[J]. Biochim Biophys Acta Rev Cancer, 2020, 1874(1): 188394. doi:10.1016/j.bbcan.2020.188394
[21] Yu HS, Hong EH, Shin YU, et al. ATP-binding cassette subfamily A-1(ABCA1)levels are increased in the aqueous humour of proliferative diabetic retinopathy patients[J]. Acta Ophthalmol, 2021, 99(3): 442-443. doi:10.1111/aos.14550
[22] Liu K, Chen LJ, Lai TY, et al. Genes in the high-density lipoprotein metabolic pathway in age-related macular degeneration and polypoidal choroidal vasculopathy[J]. Ophthalmology, 2014, 121(4):911-916. doi: 10.1016/j.ophtha.2013.10.042
[23] Yuan MZ, Han RA, Zhang CX, et al. Association of genes in the high-density lipoprotein metabolic pathway with polypoidal choroidal vasculopathy in asian population: a systematic review and meta-analysis[J]. J Ophthalmol, 2018: 9538671. doi: 10.1155/2018/9538671
[24] Nakata I, Yamashiro K, Kawaguchi T, et al.. Association between the cholesteryl ester transfer protein gene and polypoidal choroidal vasculopathy[J]. Invest Ophthalmol Vis Sci, 2013, 54(9):6068-6073. doi: 10.1167/iovs.13-11605
[25] Zhang YP, Wang YX, Zhou JQ, et al. The influence of diabetes, hypertension, and hyperlipidemia on the onset of age-related macular degeneration in north China: the kailuan eye study[J]. Biomed Environ Sci, 2022, 35(7):613-621. doi: 10.3967/bes2022.081
[26] Meng QY, Huang LZ, Sun YY, et al. Effect of high-density lipoprotein metabolic pathway gene variations and risk factors on neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in China[J]. PLoS One, 2015, 10(12): e0143924. doi:10.1371/journal.pone.0143924
[27] 王娇娇, 李苗. 糖尿病视网膜病变的机制和细胞模型研究进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(5): 93-99. doi:10.6040/j.issn.1673-3770.0.2021.203 WANG Jiaojiao, LI Miao. Progress in diabetic retinopathy mechanisms and cellular models[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(5): 93-99. doi:10.6040/j.issn.1673-3770.0.2021.203
[28] Alı?瘙塂ık M, I?瘙塂ik MU. The relationship between choroidal thickness and intracellular oxidised-reduced glutathione and extracellular thiol-disulfide homeostasis at different stages of diabetic retinopathy[J]. Curr Eye Res, 2021, 46(3): 367-372. doi:10.1080/02713683.2020.1842463
[29] Gattoussi S, Cougnard-Grégoire A, Korobelnik JF, et al. Choroidal thickness, vascular factors, and age-related macular degeneration: the alienor study[J]. Retina, 2019, 39(1): 34-43. doi:10.1097/IAE.0000000000002237
[30] Capitão M, Soares R. Angiogenesis and inflammation crosstalk in diabetic retinopathy[J]. J Cell Biochem, 2016, 117(11): 2443-2453. doi:10.1002/jcb.25575
[31] Chung YR, Park SW, Choi SY, et al. Association of statin use and hypertriglyceridemia with diabetic macular edema in patients with type 2 diabetes and diabetic retinopathy[J]. Cardiovasc Diabetol, 2017, 16(1): 4. doi:10.1186/s12933-016-0486-2
[32] Teo KYC, Yanagi Y, Wong TY, et al. Morphologic predictors and temporal characteristics of conversion from nonexudative to exudative age-related macular degeneration in the fellow eye[J]. Ophthalmol Retina, 2021, 5(2): 126-140. doi:10.1016/j.oret.2020.07.005
[33] Sanchez MC, Chiabrando GA. Multitarget activities of Müller glial cells and low-density lipoprotein receptor-related protein 1 in proliferative retinopathies[J]. ASN Neuro, 2022, 14: 175909142211363. doi:10.1177/17590914221136365
[34] 林梦圆. 2型糖尿病性视网膜病变与非高密度脂蛋白胆固醇比高密度脂蛋白胆固醇比值的相关性分析[D]. 南昌:南昌大学, 2023
[1] ZHANG Liyuan, GUO Yingzhuo, CHEN Jiao, WANG Hua, ZHONG Dingjuan. Clinical effect of 650-nm low-level red light in conjunction with orthokeratology in myopia control [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 52-57.
[2] ZHANG Liyuan, ZHONG Dingjuan, WANG Hua. Advancements in non-surgical management of myopia and choroidal research [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(4): 149-153.
[3] ZHANG Lijing, FENG Xiaoxing, LIU Nanxian, ZHAO Huiming, CHEN Yuehua. Graphene cured nasal mask combined with subcutaneous specific immunotherapy of dust mite in patients with dust mite allergic rhinitis application analysis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 26-32.
[4] LI Yang, LIU Dong, CAO Wenjie. Meta-analysis of the effect of red-light therapy on spherical equivalent, axial length, and choroidal thickness in myopic children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 74-81.
[5] CHEN Kun, LU Hui, LI Lei, ZHANG Fan, YANG Jun, HUANG Qi. Multicentric plasma cell type Castleman disease involving multiple sites in children: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(1): 54-58.
[6] ZHOU Jiamin, SONG Yuwan, SUN Yan. Research progress of pyroptosis in senile degenerative diseases [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(4): 172-180.
[7] ZHAO Lu, TIAN Huiwen, MENG Bo, WANG Wei, WANG Yanling. Analysis of macular retinal-choroidal thickness changes in patients with internal carotid artery occlusion [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(3): 72-76.
[8] XU Enpei, SUN Xianyong. Diagnosis and treatment of exudative age-related macular degeneration combined with retinal pigment epithelial detachment [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(3): 125-142.
[9] LI Mengting, HE Shuxi, WANG Hua. Research progress of inflammatory factors in Keratoconus [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(2): 151-158.
[10] WANG Luping, KOU Fangning, WANG Hao, ZHANG Canwei, WANG Yanling, YOU Ran, WU Weizhen. Effects of subretinal hyperreflective material on the visual prognosis of anti-VEGF therapy in patients with neovascular macular degeneration [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(6): 101-105.
[11] LIANG Xu,SHI Li. Research progress in biologic targeted drug therapy for chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 30-35.
[12] SUN Na, HUANG Yu, ZHANG Ruxin, ZHANG Xueyan, NIU Yue, DUAN Yusen, KAN Haidong. Effects of ozone on nuclear protein expression of NF-κB p65 in nasal mucosa and inflammatory factors in a rat model of allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 237-244.
[13] ZHANG Taoran, WANG Wei, LI Mingming, HUANG Yingxiang. Subfoveal choroidal thickness changes following intravitreal ranibizumab treatment in choroidal neovascularization due to pathological myopia [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(2): 68-71.
[14] ZHANG Jinzhuang, YIN Pu, LIU Ning, WANG Jiangyu, JIA Yunfen, DING Yuanji, WU Yao. Comparative study of the Xiangju capsule and Kangfuxin liquid in the treatment of chronic rhinosinusitis with nasal polyps after functional endoscopic sinus surgery [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(1): 69-76.
[15] Spectral-domain optical coherence tomography(SD-OCT)was used to measure and observe the characteristics of the subfoveal choroidal thickness(SFCT)in patients with ocular ischemic syndrome(OIS)as well as explore the indicators for early evaluation of OIS. MethodsThis was a retrospective case-control study. Forty-eight patients(48 eyes)were included between January 2017 and January 2020. The patients were divided into two groups: the OIS and the control groups, with each consisting of 24 patients(24 eyes). Their basic information, including age, gender, body mass index(BMI), and the history of diabetes, hypertension, and hyperlipidemia, was collected. SFCT was measured using SD-OCT in EDI mode. The basic data and SFCTs of the two groups were compared. ResultsThere were no significant differences between the ages, gender, BMIs, and the prevalence of diabetes, hypertension, and hyperlipidemia of the two groups(all P>0.05). The mean SFCT of the OIS group was 204.83±27.34 μm, and that of the control group was 226.58±33.49 μm. The differences between the two groups were statistically significant(t=2.464, P=0.018). ConclusionsSFCT was thinner in patients with OIS. SFCT can be used as an indicator for early assessment of OIS.. Analysis of choroidal thickness in patients with ocular ischemic syndromeFU Qiang, WANG Hongxing Department of Ophthalmology, Beijing Chuiyangliu Hospital, Beijing 100022, ChinaAbstract: Objective〓 [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 60-63.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd