脂质代谢标志物在早期筛查阻塞性睡眠呼吸暂停患者中阿尔兹海默症的应用价值

doi:10.6040/j.issn.1673-3770.0.2023.169

Abstract

Abstract: Obstructive sleep apnea(OSA)is a common clinical condition characterized by chronic intermittent hypoxia and sleep fragmentation, which can lead to multi-organ and multi-system dysfunction. Prior research has shown that OSA can increase the risk of Alzheimer's disease(AD), and can also trigger abnormal lipid metabolism, an important pathogenic feature of AD. In this review, we discuss the markers of abnormal lipid metabolism of OSA, discussing the possible involvement of cholesterol, phospholipid, lipoprotein and apolipoprotein metabolism in the onset and progression of Alzheimer's disease. This knowledge will be helpful in the screening of early evaluation indicators of OSA which increase the risk of AD. Further, this knowledge can be used to construct a theoretical basis for the clinical exploration of relevant biomarkers.

Key words: Obstructive sleep apnea, Alzheimer's disease, Lipid metabolism, Biomarkers, Intermittent hypoxia

CLC Number:

WANG Lu, ZHANG Yunyun, GUO Hua, CUI Xiaochuan. Application value of lipid metabolism markers for the early screening of Alzheimer's disease in obstructive sleep apnea patients[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(6): 68-74.

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Application value of lipid metabolism markers for the early screening of Alzheimer's disease in obstructive sleep apnea patients

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