鼻咽喉非霍奇金淋巴瘤64例临床分析

山东大学耳鼻喉眼学报

鼻咽喉非霍奇金淋巴瘤64例临床分析

岳利华, 程金妹, 林功标, 陈国郝,张榕, 易自翔

（福建医科大学附属第一医院耳鼻咽喉头颈外科，福建省耳鼻咽喉研究所, 福建福州 350005）

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2006-04-25 发布日期:2006-04-25

YUE Lihua， CHENG Jinmei， LIN Gongbiao， CHEN Guohao, ZHANG Rong, YI Zixiang

Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Fujian Medical University,Fujian Institute of Otolaryngology, Fuzhou 350005, Fujian, China

Received:1900-01-01 Revised:1900-01-01 Online:2006-04-25 Published:2006-04-25

摘要/Abstract

摘要： ［摘要］目的：探讨鼻咽喉非霍奇金淋巴瘤的诊断、治疗和预后。方法:回顾分析鼻咽喉非霍奇金淋巴瘤64例的临床资料，评价影响淋巴瘤的预后因素。结果:本组64例中，T细胞淋巴瘤29例，NK/T细胞淋巴瘤16例，B细胞淋巴瘤16例，3例未分型。Ann Arbor分期：Ⅰ期31例，Ⅱ期21例，Ⅲ期11例，Ⅳ期1例。25例行化疗，27例行化疗加放疗，5例行放疗。3年总生存率为67.24％，单纯化疗的3年生存率和化疗加放疗的3年生存率差异无统计学意义（P＝0.07）。单因素分析表明，Ann Arbor分期、国际预后指数（IPI）、一般状况和乳酸脱氢酶（LDH）是影响预后的因素。多因素Cox回归模型分析表明，仅IPI是影响预后的独立因素。结论:鼻咽喉非霍奇金淋巴瘤以鼻和鼻窦T细胞淋巴瘤多见，化疗加放疗并未改善疗效，IPI是判断预后的独立指标。

关键词: ［关键词］鼻咽肿瘤, 喉肿瘤, 淋巴瘤, 非霍奇金, 诊断, 预后

Abstract: ［ABSTRACT］Objective： To discuss the diagnosis, treatment and prognosis of the primary nonHodgkin lymphoma in nose, pharynx and larynx. Methods： The clinical data of 64 primary nasal, pharyngeal and laryngeal nonHodgkin lymphomas were retrospectively reviewed. The prognostic factors of the lymphoma were evaluated. Results： Of the 64 patients, 29 had T cell lymphomas, 16 NK/T cell lymphomas, 16 B cell lymphomas and 3 unclassified lymphomas; of the 31 patients of Ann Arbor stage, 21 were stageⅡ, 11 stage Ⅲand 1 stage Ⅳ; 25 patients received chemotherapy alone, 27 chemotherapy combined with radiotherapy, and 5 radiotherapy alone. The 3year overall survival rate was 67.24%. There was no significant difference of the 3year survival rate between the chemotherapy and the chemotherapy combined with radiotherapy (P=0.0704). Univariate analysis showed that Ann Arbor classification, international prognostic index (IPI), performance state and LDH were prognostic factors. Multivariate analysis by Cox regression demonstrated that only IPI was an independent prognostic factor. Conclusion： The T cell lymphoma is the predominant type of NHL in nose, pharynx and larynx. The therapy of chemotherapy combined with radiotherapy can not improve the cure rate. IPI is an independent prognostic factor.

Key words: Laryngeal neoplasms, Lymphoma, ［KEY WORDS］Nasopharynggeal neoplasms, nonHodgkin, Diagnosis, Prognosis

岳利华,程金妹,林功标,陈国郝,张榕,易自翔 . 鼻咽喉非霍奇金淋巴瘤64例临床分析[J]. 山东大学耳鼻喉眼学报, 2006, 20(2): 135-138 .

. YUE Lihua， CHENG Jinmei， LIN Gongbiao， CHEN Guohao, ZHANG Rong, YI Zixiang[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(2): 135-138 .

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