阻塞性睡眠呼吸暂停程度与中性粒细胞/淋巴细胞比值的相关性研究

doi:10.6040/j.issn.1673-3770.0.2016.347

摘要/Abstract

摘要： 目的探讨研究中性粒细胞/淋巴细胞比值(NLR)与阻塞性睡眠呼吸暂停综合征(OSAS)程度的关系。方法将158例按照睡眠期呼吸暂停低通气指数(AHI)情况分为4个组,分别为正常对照组(n=39)、轻度OSAS组(n=38)、中度OSAS组(n=41)和重度OSAS组(n=40),此外对重度OSAS组中的31例实施持续气道正压(CPAP)治疗3个月,对该31例进行CPAP治疗前后对比。比较的血细胞参数包括白细胞、中性粒细胞、淋巴细胞、中性粒细胞/淋巴细胞比值(NLR)。结果 NLR的组间比较显示重度OSAS组(3.29±1.19)显著高于正常对照组(1.71±0.69)、轻度OSAS组(1.70±0.71),中度OSAS组较正常对照组和轻度OSAS组亦明显增高(均为P<0.05),而正常对照组与轻度OSAS组间及中度OSAS组与重度OSAS组间差异无统计学意义(P>0.05)。重度OSAS患者CPAP治疗前后对比结果显示治疗后NLR(1.98±0.81)较治疗前NLR(3.28±0.62)显著降低(P<0.05)。此外4个组中NLR与睡眠期AHI是呈正相关的(r=0.758, P=0.034),同时最低氧饱和度与AHI呈负相关(r=-0.179, P=0.012)。结论 NLR可随着OSAS程度的加重而增高,因而可能作为一新的指标用来辅助评估OSAS患者体内炎症反应的严重程度。

关键词: 持续气道正压, 睡眠呼吸暂停,阻塞性, 淋巴细胞, 中性粒细胞

Abstract: Objective To investigate the relationship between the neutrophil / lymphocyte ratio(NLR)and severity of obstructive sleep apnea syndrome(OSAS). Methods A total of 158 subjects were recruited and divided into 4 groups based on their apnea hypopnea index(AHI)during sleep: control group(n=39), mild OSAS group(n=38), moderate OSAS group(n=41)and severe OSAS group(n=40). In addition, 31 patients in the severe OSAS group underwent 3-month continuous positive airway pressure(CPAP)treatment. White blood cells, neutrophils, lymphocytes and NLR were compared among groups as well as before and after CPAP treatment. Results The NLR in the severe OSAS group(3.29±1.19)was significantly higher than that in the normal control group(1.71±0.69), mild OSAS group(1.70±0.71); the NLR in the moderate OSAS group was significantly higher than that in the normal control group and mild OSAS group(all P<0.05); there was no significant difference in NLR between the normal control group and mild OSAS group as well as between the moderate OSAS group and severe OSAS group(all P>0.05). Comparison before and after CPAP treatment showed that NLR was significantly lowered after CPAP treatment(P<0.05). There was a positive correlation between AHI and NLR(r=0.758, P= 0.034), and a negative correlation between AHI and minimal oxygen saturation(r=-0.179, P=0.012). Conclusion NLR may elevate as OSAS becomes more severe and therefore it may serve as a new auxiliary parameter to evaluate the severity of inflammatory status in OSAS patients.

Key words: Neutrophils, Continuous positive airway pressure, Sleep apnea syndrome, obstructive, Lymphocytes

中图分类号:

R766.7

许梅杰,苏梅,薛荣,张希龙. 阻塞性睡眠呼吸暂停程度与中性粒细胞/淋巴细胞比值的相关性研究[J]. 山东大学耳鼻喉眼学报, 2016, 30(5): 33-37.

XU Meijie, SU Mei, XUE Rong, ZHANG Xilong. Correlation between neutrophil / lymphocyte ratio and severity of obstructive sleep apnea syndrome.[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(5): 33-37.

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