ISSN 1673-3770 CN 37-1437/R
山东大学耳鼻喉眼学报 ›› 2024, Vol. 38 ›› Issue (2): 163-168.doi: 10.6040/j.issn.1673-3770.0.2023.333
• 综述 • 上一篇
伦英俊1,陈晨2,高宏程2,范清琳3,邰仁清1
LUN Yingjun1, CHEN Chen2, GAO Hongcheng2, FAN Qinglin3, TAI Renqing1
摘要： 糖尿病视网膜病变(diabetic retinopathy, DR)是一种由糖尿病引起的微血管并发症,也是导致患者失明的首要原因。其发病机制受多种因素影响,例如免疫炎症、氧化应激、多元醇途径等。目前认为免疫炎症机制在DR的发生发展起重要作用。Toll样受体4(Toll-like receptor 4, TLR4)/核转录因子-κB(nuclear factor kappa B, NF-κB)通路是介导炎症因子释放的重要途径,在免疫炎性机制中发挥关键作用。目前不少研究证实抑制TLR4/NF-κB信号通路可有效减轻DR。本文就TLR4/NF-κB通道在DR中的作用进行综述,可为治疗DR提供新的靶点。
中图分类号:
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