山东大学耳鼻喉眼学报 ›› 2019, Vol. 33 ›› Issue (1): 49-52.doi: 10.6040/j.issn.1673-3770.1.2018.033

• 研究进展 • 上一篇    下一篇

慢性鼻窦炎伴鼻息肉与哮喘的相关性机制及治疗策略研究进展

张宇(),宋西成*()   

  1. 青岛大学附属烟台毓璜顶医院耳鼻咽喉头颈外科，山东 烟台 264000
  • 收稿日期:2018-11-06 出版日期:2019-01-20 发布日期:2019-01-28
  • 通讯作者: 宋西成 E-mail:superzhang013@163.com;songxicheng@126.com
  • 作者简介:张宇。E-mail:superzhang013@163.com|宋西成，医学博士，二级教授，主任医师，科主任，学科带头人，博士生导师。美国德克萨斯大学MD Anderson癌症中心、匹兹堡大学颅底外科中心高级访问学者。主要学术任职：中华医学会耳鼻咽喉头颈外科学分会头颈学组委员，中华医学会变态反应学分会青年委员会委员，全国耳鼻咽喉头颈外科联盟委员，中国医疗保健国际交流促进会耳鼻咽喉头颈外科分会山东省协作组组长、华东地区协作组副组长，中国医疗保健国际交流促进会过敏科学分会常务委员，中国医疗保健国际交流促进会甲状腺疾病防治分会、咽喉嗓音言语科学分会委员，中国抗癌协会康复会学术指导委员会常务委员、头颈肿瘤分会委员，中国残疾人康复协会无喉者康复专业委员会委员，中国中西医结合学会耳鼻咽喉科专业委员会鼻窦炎学组委员，中国医药教育协会头颈肿瘤专业委员会委员，山东省医师协会耳鼻咽喉科医师分会副主任委员，山东省医学会变态反应学分会青年委员会副主任委员，山东省健康管理协会耳鼻咽喉健康管理分会副主任委员，山东省研究型医院协会鼻科学分会副主任委员，山东省腔镜外科质量控制中心耳鼻喉科专家组委员，烟台市医学会耳鼻咽喉科学分会主任委员，烟台市医师协会监事长，泛亚地区面部整形与重建外科学会(PAAFPRS)中国区委员。《Molecular Cancer》《BMC Cancer》等杂志审稿人，《中华耳鼻咽喉头颈外科杂志》《中国耳鼻咽喉头颈外科》《中国中西医结合耳鼻咽喉科杂志》编委，《山东大学耳鼻喉眼学报》副主编。主要研究方向：头颈肿瘤的发病机制及临床诊治、鼻颅底外科

Advances in interaction mechanisms and treatment strategy between chronic rhinosinusitis with nasal polyp and asthma

Yu ZHANG(),Xicheng SONG*()   

  1. Department of Otorhinolaryngology Head and Neck Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong, China
  • Received:2018-11-06 Online:2019-01-20 Published:2019-01-28
  • Contact: Xicheng SONG E-mail:superzhang013@163.com;songxicheng@126.com

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摘要：

慢性鼻窦炎伴鼻息肉(CRSwNP)和哮喘作为上下呼吸道最具代表性的慢性炎症性疾病，二者在发病过程中常相互并存，临床诊治棘手。目前对CRSwNP和哮喘的相互作用机制尚未阐明。欧洲鼻窦炎鼻息肉诊疗指南(EPOS 2012)对治疗CRSwNP伴或不伴哮喘已给出具体的指导意见，其常规治疗包括鼻用糖皮质激素、生理盐水洗鼻等，并进一步根据CRSwNP的特点、症状严重程度等进行后续的联合治疗。据报道，鼻窦手术和药物治疗CRSwNP对合并支气管哮喘的转归有益。但CRSwNP合并哮喘患者经药物与手术治疗后的疗效判定尚缺乏足够的随机对照试验证据。

关键词: 慢性鼻窦炎伴鼻息肉, 哮喘, 联合气道, 发病机制, 治疗

Abstract:

Chronic rhinosinusitis with nasal polyp (CRSwNP) and asthma are representative chronic inflammatory diseases, which often coexist in the upper and lower airways. It is difficult to perform an effective therapy for patients with CRSwNP accompanied by asthma because interaction mechanisms and therapeutic effects after medical treatment and endoscopic sinus surgery remain unclear. The European position paper on rhinosinusitis and nasal polyps 2012 (EPOS 2012) presents detailed guidelines on the therapy of CRSwNP with or without asthma, including intranasal corticosteroids, nasal irrigation with saline, and so on. In addition, comprehensive follow-up treatments need to be performed according to the feature and severity of symptoms of CRSwNP. Research shows that it is beneficial for improving the prognosis of patients with CRSwNP accompanied by asthma by combining sinus surgery with medical treatment, but further randomized clinical trials are needed to better understand the management of asthma accompanied by CRSwNP.

Key words: Chronic rhinosinusitis with nasal polyp, Asthma, United airways, Pathogenesis, Therapy

中图分类号: 

  • R765.41
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