优化脉冲光联合睑板腺按摩治疗睑板腺功能障碍的临床效果观察

doi:10.6040/j.issn.1673-3770.0.2020.341

摘要/Abstract

摘要： 目的研究优化脉冲光联合睑板腺按摩治疗睑板腺功能障碍的临床效果。方法采用前瞻性病例对照研究,观察诊断为睑板腺功能障碍的患者86例172眼。将患者随机分为试验组和对照组,每组43例86眼。两组患者给予优化脉冲光治疗,每4周1次,共4次,试验组在每次治疗后进行睑板腺按摩。记录患者治疗前及首次治疗后4、8、12及16周时患者眼表疾病指数(OSDI)评分、非侵入性泪膜破裂时间(NITBUT)、非侵入性泪河高度(NITMH)、睑板腺评分(MGS)及睑板腺分泌物评分(MGYSS)等数据,进行统计学分析。结果两组治疗后各时间点除NITMH、MGS外各项指标均较治疗前有明显改善(P<0.001)。试验组OSDI评分结果在治疗4周时与对照组无差异(P=0.857),其他时间点均优于对照组(P_8周=0.002,P_12周=0.024,P_16周<0.001)。试验组NITBUT各时间点评分结果均优于对照组(P<0.001)。试验组MGYSS各时间点评分均优于对照组(P_4周<0.001,P_8周=0.005,P_12周=0.045,P_16周=0.013)。结论优化脉冲光技术联合睑板腺按摩能缓解症状、稳定泪膜、减轻炎症,治疗MGD效果明显。

关键词: 脉冲光, 睑板腺按摩, 睑板腺功能障碍, 治疗, 临床效果

Abstract: Objective To evaluate the clinical effect of optimal pulse technology combined with meibomian gland massage to treat meibomian gland dysfunction. Methods We performed a prospective analysis of 172 eyes of 86 patients with meibomian gland dysfunction from May to December 2019. The study population was randomly divided into observation and control groups, each including 86 eyes of 43 patients. All patients were treated with optimal pulse technology for a total of 4 times, once every 4 weeks. Patients in the observation group underwent meibomian gland massage after each treatment. The ocular surface disease index(OSDI)score, noninvasive tear break-up time(NITBUT), noninvasive tear meniscus height(NITMH), meibomian gland score(MGS), and meibomian gland yielding secretion score(MGYSS)were recorded before and after the first treatment. Results The indices recorded at each time point, except for NITMH and MGS, improved significantly(P<0.001). The OSDI score did not differ between the two groups at 4 weeks after the treatment(P=0.857)and was better in the observation group than in the control group at other time points(P_{8 weeks}=0.002, P_{12 weeks}=0.024, P_{16 weeks}<0.001). NITBUT was better in the observation group than in the control group at each time point(P<0.001; P_{4 weeks}<0.001, P_{8 weeks}=0.005, P_{12 weeks}=0.045, P_{16 weeks}=0.013). Conclusions The optimal pulse technology combined with meibomian gland massage can relieve symptoms, stabilize tear film, and reduce inflammation. The treatment effect is obvious.

Key words: Optimal pulse technology, Meibomian gland massage, Meibomian gland dysfunction, Treatment, Clinical effect

中图分类号:

R777

李威,张斌. 优化脉冲光联合睑板腺按摩治疗睑板腺功能障碍的临床效果观察[J]. 山东大学耳鼻喉眼学报, 2021, 35(2): 105-109.

LI Wei, ZHANG Bin. Effects of optimal pulse technology combined with meibomian gland massage to treat meibomian gland dysfunction[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(2): 105-109.

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